Research work is focused on molecular mechanism of T cell immunity, particularly the function of cytotoxic T lymphocytes (CTL) in chronic viral infections and tumors. Antigen presentations and T cell receptors (TCR) interacting with peptide-MHC/HLA are especially emphasized. HIV, hepatitis B or C virus, avian influenza virus are used as research materials in the relevant field and rhesus macaque model is used to evaluate these data for immune response and vaccine development. We are also interested in the molecular mechanism of innate immunity, especially its role in the recognition of some components derived from TCM herbs. Cell cycle and carcinogenesis and cellular signaling pathway are also studied in the center. Nano-antibodies against various targets are being developed in the center.

Principal Investigators:
George Fu Gao　　　Protein-protein interactions, molecular mechanism of virus interspecies transmission
Xin Ye　　　　　　　Signal transduction pathway in cell cycle regulation
Bin Gao　　　　　　Antigen processing & presentation, immune responses. Vaccine & immune therapy
Jilong Chen　　　　 Cancer immunology