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Max-Planck Partner Group for Bioinformatics and Computational Biology

 

 

    

 

PI: Jun Wang, Dr. rer. nat, Professor

 

 Telephone: +86-10-64807502
 E-mail: junwang@im.ac.cn
 Add: Room B202, West Beichen Road, Chaoyang District, Beijing 100101, China

 

 

Research Interests

 

1 Microbiome composition, functionality and dynamics in human health and disease

2 Artificial intelligence approaches and their application in microbiome analysis

3 High-throughput systems in studying microbiome-host interactions

4 Application of novel sequencing and other omics analytical technologies

 

Education/degrees

 

2014  Dr. rer. nat, summa cum laude. Max-Planck-Institute for Evolutionary Biology, Ploen, Germany

2010  MSc., summa cum laude, Erasmus Mundus Master Program EMBC. University Ghent, Belgium; University Oviedo, Spain & University Bremen, Germany

2008  BSc., honorary graduate, Ocean University China, Qingdao, PRC

  

 

 

Research experience

 

2014-2017  Postdoc researcher, Rega Institute, KU Leuven/ VIB Center for Microbiology, KU Leuven, Belgium

 

Awards & Honors 

 

26/11/2016    FWO Research Project Grant (40,000 Euro)

25/05/2014    Chinese Government Award for Outstanding PhD Students Overseas, Chinese Scholarship Committee

01/01/2012 – 30/04/2014    DFG PhD Scholarship, Max-Planck-Institute for Evolutionary Biology, Ploen, Germany

01/10/2010 – 30/12/2011    Max Planck Society PhD fellowship, Max-Planck-Institute for Evolutionary Biology, Ploen, Germany

01/09/2008 – 01/07/2010    Erasmus Mundus Master Scholarship, European Union

 

 

Selected publications

 

 

 1.         Xizhan XuZezheng Gao, Fuquan Yang, Yingying Yang, Liang Chen, Lin Han, Na Zhao, Jiayue Xu, Xinmiao Wang, Yue Ma, Lian Shu, Xiaoxi Hu, Na Lyu, Yuanlong Pan, Baoli Zhu, Linhua Zhao, Xiaolin Tong*, Jun Wang*. Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient, Berberine. Genomics, Proteomics & Bioinformatics. In press

 

2.         Wei Zheng, Yue Ma, Ai Zhao, Tingchao He, Na Lyu, Ziqi Pan, Geqi Mao, Yan Liu, Jing Li, Peiyu Wang, Jun Wang*, Baoli Zhu* & Yumei Zhang*. Compositional and functional differences in human gut microbiome with respect to equol production and its association with blood lipid level: a cross-sectional study. Gut Pathogens 2019, 11:20 doi:10.1186/s13099-019-0297-6

 

3.         Jun Wang#, Alexander Kurilshikov, Djawad Radjabzadeh, Williams Turpin, Kenneth Croitoru, Marc Jan Bonder, Matthew A. Jackson, Carolina Medina-Gomez, Fabian Frost, Georg Homuth, Malte Rühlemann, David Hughes, Han-na Kim, MiBioGen Consortium Initiative, Tim D. Spector, Jordana T. Bell, Claire J. Steves, Nicolas Timpson, Andre Franke, Cisca Wijmenga, Katie Meyer, Tim Kacprowski, Lude Franke, Andrew D. Paterson, Jeroen Raes Robert Kraaij Alexandra Zhernakova. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Microbiome, 2018 6:101

 

4.         Jun Wang#, Liang Chen, Na Zhao, Xizhan Xu, Yakun Xu, Baoli Zhu. Of genes and microbes: solving the intricacies in host genomes. Protein Cell. 2018 9(5):446-461

 

5.         Jun Wang*, Louise B. Thingholm , Jurgita Skieceviciene, *, Philipp Rausch, Martin Kummen, Johannes R. Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C. Rühlemann, Silke Szymczak, Kristian Holm, Tonu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, Jorn Bethune, Felix Sommer, David Ellinghaus, Rolf K. Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patricia Hübbe, Wei-Hung Pan, Raheleh Sheibani-Tezerji, Robert Hasler, Philipp Rosenstiel, Mauro D’Amato, Katja Cloppenborg-Schmidt, Sven Künzel, Matthias Laudes, Hanns-Ulrich Marschal, Wolfgang Lieb, Ute Nothlings, Tom H. Karlsen, John F. Baines, Andre Franke. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nature Genetics, 2016 (48)1396–1406 ((* contributed equally; Nature Genetics封面文章)

 

6.         Gwen Falony*, Marie Joossens*, Sara Vieira-Silva*, Jun Wang*, Youssef Darzi, Karoline Faust, Alexander Kurilshikov, Marc Jan Bonder, Mireia Valles-Colomer, Doris Vandeputte , Raul Y Tito, Samuel Chaffron, Leen Rymenans, Chloe Verspecht, Lise De Sutter, Gipsi Lima-Mendez, Kevin D'hoe, Karl Jonckheere, Daniel Homola, Roberto Garcia, Ettje F. Tigchelaar, Linda Eeckhaudt, Jingyuan Fu, Liesbet Henckaerts, Alexandra Zhernakova, Cisca Wijnenga, Jeroen Raes. Population-level analysis of gut microbiome variation. Science, 2016, 352(6285):560-565  (* contributed equally; Science封面文章)

 

7.         Alexander R. Moschen*, Romana R. Gerner*, Jun Wang*, Victoria Klepsch, Timon E. Adolph, Simon J. Reider, Hubert Hackl, Alexandra Pfister, Johannes Schilling, Patrizia L. Moser, Sarah L. Kempster, Alexander Swidsinski, Dorothea Orth-Holler, Günter Weiss, John F. Baines, Arthur Kaser, Herbert Tilg. Lipocalin 2 protects from colonic inflammation and tumorigenesis through its microbiota modulating properties. Cell Host Microbes, 2016, 19(4):455–469 (* contributed equally)

 

8.         Jun Wang, Shirin Kalyan, Natalie Steck, Leslie M. Turner, Bettina Harr, Sven Künzel, Marie Vallier, Robert Hasler, Andre Franke, Hans-Heinrich Oberg, Saleh M. Ibrahim, Guntram A. Grassl, Dieter Kabelitz, John F. Baines. Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome. Nature Communications 2015, 6:6440.

 

9.         Jun Wang, Miriam Linnenbrink, Sven Künzel, Ricardo Fernandes, Marie-Josée Nadeau, Philip Rosenstiel, John F Baines. Dietary history contributes to enterotype-like clustering and functional metagenomic content in the intestinal microbiome of wild mice. Proceedings of the National Academy of Sciences 2014, 11(26):E2703-E2710.

 

10.   Miriam Linnenbrink*, Jun Wang*, Emilie A Hardouin, Sven Künzel, Dirk Metzler, John F Baines: The role of biogeography in shaping diversity of the intestinal microbiota in house mice. Molecular Ecology 2013, 22(7):1904-1916.

 

 

Other publications:

 

1.         Chang Liu, Nan Zhou, Meng-Xuan Du, Yu-Tong Sun, Kai Wang, Yu-Jing Wang, Dan-Hua Li, Hai-Ying Yu, Yuqin Song, Bing-Bing Bai, Yuhua Xin, Linhuan Wu, Cheng-Ying Jiang, Jie Feng, Hua Xiang, Yuguang Zhou, Juncai Ma, Jun Wang, Hong-Wei Liu & Shuang-Jiang Liu. The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria. Nature Communications 2020, 11:79

 

2.         Joossens, Marie, Karoline Faust, Tessa Gryp, Anh Thi Loan Nguyen, Jun Wang, Sunny Eloot, Eva Schepers, Annemieke Dhondt, Anneleen Pletinck, Sara Vieira-Silva, Gwen Falony, Mario Vaneechoutte, Raymond Vanholder, Wim Van Biesen, Geert Roger Bertrand Huys, Jeroen Raes, and Griet Glorieux. Gut Microbiota Dynamics and Uraemic Toxins: One Size Does Not Fit All. Gut 2019 doi http://dx.doi.org/10.1136/gutjnl-2018-317561

 

3.         Mireia Valles-Colomer, Gwen Falony, Youssef Darzi, Ettje F. Tigchelaar, Jun Wang, Raul Y. Tito, Carmen Schiweck, Alexander Kurilshikov, Marie Joossens, Cisca Wijmenga, Stephan Claes, Lukas Van Oudenhove, Alexandra Zhernakova, Sara Vieira-Silva & Jeroen Raes. The neuroactive potential of the human gut microbiota in quality of life and depression. Nature Microbiology 2019 doi:s41564-018-0337-x

 

4.         Ilias Lagkouvardos, Till R. Lesker, Thomas C. A. Hitch, Eric J. C. Gálvez, Nathiana Smit, Klaus Neuhaus, Jun Wang, John F. Baines, Birte Abt, Barbel Stecher, Jorg Overmann, Till Strowig and Thomas Clavel. Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family. Microbiome 2019 7:28

 

5.         Kai Wang, Mingfang Liao, Nan Zhou, Li Bao, Ke Ma, Zhongyong Zheng, Yujing Wang, Chang Liu, Wenzhao Wang, Jun Wang, Shuang-Jiang Liu, Hongwei Liu. Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids. Cell Reports, 2019, 26(1):222-235.e5. doi: 10.1016/j.celrep.2018.12.028

 

6.         Wenyu Shi, Heyuan Qi, Qinglan Sun, Guomei Fan, Shuangjiang Liu, Jun Wang, Baoli Zhu, Hongwei Liu, Fangqing Zhao, Xiaochen Wang, Xiaoxuan Hu, Wei Li, Jia Liu, Ye Tian, Linhuan Wu, Juncai Ma. gcMeta: a Global Catalogue of Metagenomics platform to support the archiving, standardization and analysis of microbiome data. 2018. Nucleic Acids Research, gky1008, doi:10.1093/nar/gky1008

 

7.         Leen Boesmans, Mireia Valles-Colomer, Jun Wang, Venessa Eeckhaut, Gwen Falony, Richard Ducatelle, Filip Van Immerseel, Jeroen Raes, Kristin Verbeke. Butyrate Producers as Potential Next-Generation Probiotics: Safety Assessment of the Administration of Butyricicoccus pullicaecorum to Healthy Volunteers. mSystems. 2018, 3(6): e00094-18.

 

8.         Raul Y Tito, Samuel Chaffron, Clara Caenepeel, Gipsi Lima-Mendez, Jun Wang, Sara Vieira-Silva, Gwen Falony, Falk Hildebrand, Youssef Darzi, Leen Rymenans, Chloe Verspecht, Peer Bork, Severine Vermeire, Marie Joossens, Jeroen Raes. Population-level analysis of Blastocystis subtype prevalence and variation in the human gut microbiota. Gut 2018. epub ahead of print

 

9.         Kai Wang, Li Bao, Nan Zhou, Jinjin Zhang, Mingfang Liao, Zhongyong Zheng, Yujing Wang, Chang Liu , Jun Wang, Lifeng Wang, Wenzhao Wang, ShuangJiang Liu, Hongwei Liu. Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo. J Med Chem. 2018  61(8):3609-3625

 

10.     Louise Thingholm, Malte Rühlemann, Jun Wang, Matthias Hübenthal, Wolfgang Lieb, Matthias Laudes, Andre Franke, Mauro D’Amato. Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. Gut 2018 gutjnl-2017-315841

 

11.     Nádia Conceicao-Neto, Ward Deboutte, Tim Dierckx, Kathleen Machiels, Jun Wang, Kwe Claude Yinda, Piet Maes, Marc Van Ranst, Marie Joossens, Jeroen Raes, Séverine Vermeire, Jelle Matthijnssens. Low eukaryotic viral richness is associated with faecal microbiota transplantation success in patients with UC. Gut 2018, 67 (8) 1558-1559;

 

12.     Xiaoxi B. Lin, Tuo Wang, Paul Stothard, Jukka Corander, Jun Wang, John F. Baines, Sarah C. L. Knowles, Laima Baltrūnaite, Guergana Tasseva, Robert Schmaltz, Stephanie Tollenaar, Liz A. Cody, Theodore Grenier, Wei Wu, Amanda E. Ramer-Tait, Jens Walter. The evolution of ecological facilitation within mixed-species biofilms in the mouse gastrointestinal tract. ISME J  2018 doi:10.1038/s41396-018-0211-0

 

13.     Doris Vandeputte, Gunter Kathagen, Kevin D’hoe, Sara Vieira-Silva, Mireia Valles-Colomer, Joao Sabino, Jun Wang, Raul Y. Tito, Lindsey De Commer, Youssef Darzi, Séverine Vermeire, Gwen Falony, Jeroen Raes. Quantitative microbiome profiling links gut community variation to microbial load. Nature 2017, 551:507–511

 

14.     Doris Vandeputte, Gwen Falony, Sara Vieira-Silva, Jun Wang, Manuela Sailer, Stephan Theis, Kristin Verbeke, Jeroen Raes. Prebiotic inulin-type fructans induce specific changes in the human gut microbiota. Gut 2017, advanced online publication

 

15.     Jens Christian Claussen , Jurgita Skieceviciene, Jun Wang, Philipp Rausch, Tom H. Karlsen, Wolfgang Lieb, John F. Baines, Andre Franke , Marc-Thorsten Hütt. Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome. PLoS Comput Biol. 2017 Jun 22;13(6):e1005361.

 

16.     Tom Holvoet, Marie Joossens, Jun Wang, Jerina Boelens, Bruno Verhasselt, Debby Laukens, Hans van Vlierberghe, Pieter Hindryckx, Martine De Vos, Danny De Looze, Jeroen Raes: Assessment of faecal microbial transfer in irritable bowel syndrome with severe bloating. Gut 2016;  DOI:10.1136/gutjnl-2016-312513

 

17.     Ilias Lagkouvardos, Rüdiger Pukall, Birte Abt, Barbel U. Foesel, Jan P. Meier-Kolthoff, Neeraj Kumar, Anne Bresciani, Inés Martínez, Sarah Just, Caroline Ziegler, Sandrine Brugiroux, Debora Garzetti, Mareike Wenning, Thi P. N. Bui, Jun Wang, Floor Hugenholtz, Caroline M. Plugge, Daniel A. Peterson, Mathias W. Hornef, John F. Baines, Hauke Smidt, Jens Walter, Karsten Kristiansen, Henrik B. Nielsen, Dirk Haller, Jorg Overmann, Barbel Stecher, Thomas Clavel: The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nature Microbiology 2016; 1. DOI:10.1038/nmicrobiol.2016.131

 

18.     Alexandra Zhernakova, Alexander Kurilshikov, Marc Jan Bonder, Ettje F. Tigchelaar, Melanie Schirmer, Tommi Vatanen, Zlatan Mujagic, Arnau Vich, Gwen Falony, Sara Vieira-Silva, Jun Wang, Floris Imhann, Eelke Brandsma, Soesma A. Jankipersadsing, Marie Joossens, Maria Carmen Cenit, Patrick Deelen, Morris A. Swertz, Rinse K. Weersma, Edith J. M. Feskens, Mihai G. Netea, Dirk Gevers, Daisy Jonkers, Lude Franke, Yurii S. Aulchenko, Curtis Huttenhower, Jeroen Raes, Marten H. Hofker, Ramnik J. Xavier, Cisca Wijmenga, Jingyuan Fu. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science, 2016, 352(6285): 565-569.

 

19.     Kenneth Peuker, Stefanie Muff, Jun Wang, Sven Künzel, Esther Bosse, Yvonne Zeissig, Giuseppina Luzzi, Marijana Basic, Anne Strigli, Andrea Ulbricht, Arthur Kaser, Alexander Arlt, Triantafyllos Chavakis, Gijs R van den Brink,, Clemens Schafmayer, Jan-Hendrik Egberts,Thomas Becker, Marco E Bianchi, André Bleich, Christoph Rocken, Jochen Hampe, Stefan Schreiber,John F Baines, Richard S Blumberg, Sebastian Zeissig. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nature Medicine, 2016, epub ahead of print.

 

20.     Ateequr Rehman, Rausch Phylip, Jun Wang, Jurgita Skieceviciene, Gediminas Kiudelis, Ketan Bhagalia, Deepak Amarapurkar, Limas Kupcinskas, Stefan Schreiber, Rosenstiel Phillip, Baines John F, Stephan Ott. Geographical patterns of the standing and active human gut microbiome in health and IBD. Gut 2016, 65(2):238-248.

 

21.     Severine Vermeire, Marine Joossens, Kerstin Verbeke, Jun Wang, Kathleen Machiels, Mike Ferrante, Gert Van Assche, Peter Rutgeerts, Jeroen Raes. Donor species richness determines fecal microbiota transplantation success in inflammatory bowel disease. Journal of Crohn’s and Colitis, 2015 advanced online publication

 

22.     Gipsi Lima-Mendez, Karoline Faust, Nicolas Henry, Johan Decelle, Sébastien Colin, Fabrizio Carcillo, Samuel Chaffron, J. Cesar Ignacio-Espinosa, Simon Roux, Flora Vincent, Lucie Bittner, Youssef Darzi, Jun Wang, Stéphane Audic, Léo Berline, Gianluca Bontempi, Ana M Cabello, Laurent Coppola, Francisco M Cornejo-Castillo, Francesco d'Ovidio, Luc De Meester, Isabel Ferrera, Marie-José Garet-Delmas, Lionel Guidi, Elena Lara, Stéphane Pesant, Marta Royo-Llonch, Guillem Salazar, Pablo Sánchez, Marta Sebastian, Caroline Souffreau, Céline Dimier, Marc Picheral, Sarah Searson, Stefanie Kandels-Lewis, , Gabriel Gorsky, Fabrice Not, Hiroyuki Ogata, Sabrina Speich, Lars Stemmann, Jean Weissenbach, Patrick Wincker, Silvia G Acinas, Shinichi Sunagawa, Peer Bork, Matthew B Sullivan, Eric Karsenti, Chris Bowler, Colomban de Vargas, Jeroen Raes, Daniele Iudicone. Ocean plankton. Determinants of community structure in the global plankton interactome. Science 2015, 48(6237):1262073.

 

23.     Shirin Kalyan, Jun Wang, Quabius ES, Jorn Huck, Jorg Wiltfang, Baines JF, Dieter Kabelitz. Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw. Journal of Translational Medicine 2015, 13(1):212.

 

24.     Annelies Geirnaert, Jun Wang, Magali Tinck, Alix Steyaert, Pieter Van den Abbeele, Venessa Eeckhaut, Ramiro Vilchez-Vargas, Gwen Falony, Debby Laukens, Martine De Vos, Filip Van Immerseel, Jeroen Raes, Nico Boon, Tom Van de Wiele. Interindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25-3T studied in an in vitro gut model. FEMS Microbiology Ecology 2015, 91(6).

 

25.     Markus Tschurtschenthaler, Jun Wang, Cornelia Fricke, Teresa M J Fritz, Lukas Niederreiter, Timon E Adolph, Edina Sarcevic, Sven Künzel, Felix A Offner, Ulrich Kalinke, John F Baines, Herbert Tilg, Arthur Kaser. Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration. Gut 2014, 63(12):1921-1931.

 

26.     Jun Wang, Sven Kuenzel, John F Baines: Draft Genome Sequences of 11 Staphylococcus epidermidis Strains Isolated from Wild Mouse Species. Genome Announcements 2014, 2(1).

 

27.     Girish Srinivas, Steffen Moller, Jun Wang, Sven Künzel, Detlef Zillikens, John F Baines, Saleh M Ibrahim. Genome-wide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering. Nature Communications 2013, 4:2462.

 

28.     Soren Franzenburg, Jonas Walter, Sven Künzel, Jun Wang, John F Baines, Thomas C G Bosch, Sebastian Fraune. Distinct antimicrobial peptide expression determines host species-specific bacterial associations. Proceedings of the National Academy of Sciences 2013, 110(39).

 

 

 

 

 

 
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