Principle Investigator: Dr. Prof.Songnian Hu Tel/Fax：010-64806939 E-mail：husn@im.ac.cn

Research area   Genome mining;Bioinformatics research

Research Interest   Development of metagenomic technologies and methods for analyzing microbial communities. Single-cell metagenomic detection and library construction technology for precision sampling in microbial resource. Precision medicine analysis toolkit for better understanding of the correlation between metabolism network, colony evolution and the clinical phenotypes. Construction of comprehensive bioinformatic platform for microbial multi-omics data. Microbial genomics comprehensive analysis platform for multi-source omics data from human, animals and plants. Tracking database for metadata of samples and workflows, which enables long-term tracking and multidimensional comparison. Bioinformatic datamining and utilizing of microbial genome resources. Discovery of important genes and functional elements from microbial genome resources. Identification and characterization of new functions of genes and elements, analysis of the evolution and genetics of these elements. Supply of genomic knowledgebase for synthetic biology, genome editing and genome engineering.

Group members   Principle investigator Dr. Prof.Songnian Hu Institute of Microbiology, Chinese Academy of Sciences, No.1 West Beichen Road, Chaoyang District, Beijing 100101, P. R. China Tel/ Fax: 86-10-64806939 E-mail: husn@im.ac.cn   Education  Jul. 1991:  B.S. in Food Engineering, Tianjin University of Commerce, Tianjin, China Jul. 1996:  Ph.D. in Plant Biochemistry, China Agricultural University, Beijing, China

Professional Experience   1996-1999: Assistant Professor, Institute of Basic Medical Sciences, CAMS, China 1998-1999: Senior Fellow, Genome Center, University of Washington, USA. 1999-2002: Chief Engineer, Beijing Genomics Institute, China 2002-2004: Director, Hangzhou Genomics Institute, China 2004-2019: Professor for Beijing Institute of Genomics, CAS, China 2006-2019: Deputy Director for CAS Key Laboratory of Genome Sciences and Information, CAS, China Since 2019: Professor for Institute of Microbiology, CAS, China

Permanent stuff   Dr. Yingfeng Luo Associate Professor luoyf@im.ac.cn Research Interest: Bioinformatics, comparative genomic analysis and its applications Xinyu Tan Laboratory Technician tanxy@im.ac.cn Research Interest: Senior laboratory technician Dr. Jianing Geng Assistant professor gengjn@im.ac.cn Research Interest: Microbial Functional Genomics,Bioinformatics&&Biomedicine Chang Shu Assistant professor shuc@im.ac.cn Research Interest: Pharmacogenomics Oncogenomics,DiseaseGenomics Ruoyu Jia Research assistant jiary@im.ac.cn Xiaochun Bi Laboratory technician bixc@im.ac.cn Research Interest: Responsible for experimental operation

Postdoctoral fellow   SenghanGao Postdoctoral fellow gaoshh@im.ac.cn Research Interests: Precision structual analysis of microbial genomes and Development of bioinformatics tools and databases

Graduate students   Hao Liang (Ph. D student) Yan Sun (Ph. D student) Qian-hui Zhu (Ph. D student) TaoYu (Ph. D student) Xin Zheng (M. Sc student) Sai-nan Luo (M. Sc student) Ke-xin Li (M. Sc student) Jing-yi Nie (M. Sc student)

Representative Pictures   The genome assembly and genetic analysis of maize cultivar HuangZaoSi (2019)   Geographic distribution of maize planting area and yield in major maize-growing countries. Pie charts (red) show the proportions of planted areas of HZS-related cultivars within each province of China.    New improvements and updates for web base phylogenetic tree visualization and annotation toolkit EvolView. (2019)       Research of genome structural plasticity -Rice           Research of genome structural plasticity –The rubber tree     Research of genome structural plasticity –Date palm           Research of genome structural plasticity –Genomics of microbiology         Microbiology and diseases      EvolView v1/v2/v3

Recent Publications   1. Li, C., Song, W., Luo, Y., Gao, S., Zhang, R., Shi, Z., Wang, X., Wang, R., Wang, F., Wang, J., Zhao, Y., Su, A., Wang, S., Li, X., Luo, M., Wang, S., Zhang, Y., Ge, J., Tan, X., Yuan, Y., Bi, X., He, H., Yan, J., Wang, Y.,Hu, S*.& Zhao, J. The HuangZaoSi maize genome provides insights into genomic variation and improvement history of maize. Molecular Plant12, 402-409, doi:10.1016/j.molp.2019.02.009 (2019). 2. Subramanian, B., S. Gao, M. J. Lercher,S. Hu*and W. H. Chen*， Evolview v3: a webserver for visualization, annotation, and management of phylogenetic trees. Nucleic Acids Res, 2019. 47(W1): p. W270-W275. 3. Tang, C*., M. Yang, Y. Fang, Y. Luo, S. Gao, X. Xiao, Z. An, B. Zhou, B. Zhang, X. Tan, H. Y. Yeang, Y. Qin, J. Yang, Q. Lin, H. Mei, P. Montoro, X. Long, J. Qi, Y. Hua, Z. He, M. Sun, W. Li, X. Zeng, H. Cheng, Y. Liu, J. Yang, W. Tian, N. Zhuang, R. Zeng, D. Li, P. He, Z. Li, Z. Zou, S. Li, C. Li, J. Wang, D. Wei, C. Q. Lai, W. Luo, J. Yu,S. Hu*and H. Huang*,The rubber tree genome reveals new insights into rubber production and species adaptation. Nat Plants, 2016. 2(6): p. 16073. 4. Wang, S., Wang, S., Luo, Y., Xiao, L., Luo, X., Gao, S., Dou, Y., Zhang, H., Guo, A., Meng, Q., Hou, J., Zhang, B., Zhang, S., Yang, M., Meng, X., Mei, H., Li, H., He, Z., Zhu, X., Tan, X., Zhu, X.-Q., Yu, J., Cai, J., Zhu, G.,Hu, S*. & Cai, X. Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nature communications7, 12845, doi:10.1038/ncomms12845 (2016). 5. He, Z., H. Zhang, S. Gao, M. J. Lercher, W. H. Chen* andS. Hu*,Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees. Nucleic Acids Res, 2016.44(W1): p. W236-41. 6. Dai, X., Y. Tian, J. Li, Y. Luo, D. Liu, H. Zheng, J. Wang, Z. Dong,S. Hu*and L. Huang*，Metatranscriptomic analyses of plant cell wall polysaccharide degradation by microorganisms in the cow rumen. Appl Environ Microbiol, 2015.81(4): p. 1375-86.