Multitrophic Interactions in Plant viral diseases----INSTITUTE OF MICROBOLOGY CHINESE ACADEMY OF SCIENCES

Ye JianAssociate Professor

Dept：State Key Laboratory of Plant Genomics

Telephone：010-64807363；

E-mail：jianye@im.ac.cn

Add：NO.1 Beichen WestRoad,Chaoyang District,Beijing 100101,P.R.China

Research Interests

Vector-borne diseases account for more than 17% of all infectious diseases in human, causing more than 1 million deaths annually. Due to its sessile host, about 80% of 1100 reported viruses in plants were found to be transmitted by insect vector and costs several billon US dollars annually. The main research interest for Prof. Ye’s lab is to underpin molecular mechanisms of multitrophic interactions which can be used to control virus infection by using invasive whitefly transmitted geminiviruses as model system. A real viral disease under field condition always involves in multitrophic interactions, mainly referring a tritrophic interactions to the living community of the virus, the host plants and the insect vector. They further form a network with the core--plant chemical and physic defense against herbivory. The plant defense system stimulates the ecological impacts of a few more trophic levels?on each other: the virus, the plant, the root microbiome, the herbivore, and its?natural enemies such as?hyperparasitoids?or higher-order predators, are also considered. The underpin of the molecular mechanisms in the multitrophic interactions will enhance our capacity to control insect-transmitted viral diseases by environmental-friend methodologies.

Adult whitefly fights with its natural enemy who eats their eggs.

Career Experience:

Principal Investigator, Associated Professor,

Institute of Microbiology, Chinese Academy of Sciences (2014 to now)

Principal Investigator, Assistant Director(2013 to 2014)

Temasek Life Sciences Laboratory

Strategic Research Program (SRP)Manager,(2011—2012)

Temasek Life Sciences Laboratory

Research Fellow(2009- 2010)Temasek Life Sciences Laboratory, Singapore.
Postdoctoral Fellow(2007- 2009)
Temasek Life Sciences Laboratory, Singapore.

Education:

Ph.D. (2000-2007),Institute of Microbiology, Chinese Academy of Sciences

B. S(1996-2000),Zhejiang University, China.

Publications:

Year of 2015 (* corresponding author, # co-first author)

1. Ye J*, Yang J, Sun Y, Zhao P, Gao S, Jung C, Qu J, Fang R, Chua NH*. 2015. Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. PLoS pathogens 11:e1005196.

2. Sun YW Tee CS, Ma YH, Wang G, Yao XM, Ye J*. 2015. Attenuation of Histone Methyltransferase KRYPTONITE-mediated transcriptional gene silencing by Geminivirus. Scientific reports.Accepted.

3. Li R, Tee C, Jiang Y, Jiang X, Venkatesh P, Sarojam R, Ye J*. 2015. A terpenoid phytoalexin plays a role in basal defense ofNicotiana benthamianaagainst Potato virus X. Scientific reports 5:9682.

4. Wang H NQ, Wu HW, Liu J, Ye J, Yu N, Chua NH. 2015. Analysis of noncoding transcriptome in rice and maize uncovers roles of conserved lncRNAs associated with agriculture traits. The Plant Journal 84 2: 404-416.

5. Lee M, Xia J, Zou Z, Ye J, Rahmadsyah, Alfiko Y, Jin J, Lieando J, Purnamasari M, Lim C, Suwanto A, Wong L, Chua N, Yue G. 2015. A consensus linkage map of oil palm and a major QTL for stem height. Scientific reports 5:8232.

Year of 2014

6. Li R, Weldegergis BT, Li J, Jung C, Qu J, Sun Y, Qian H, Tee C, van Loon JJ, Dicke M, Chua NH, Liu SS, Ye J*. 2014. Virulence Factors of Geminivirus Interact with MYC2 to Subvert Plant Resistance and Promote Vector Performance. The Plant cell 26:4991-5008.

7. Ye J, Qu J, Mao HZ, Ma ZG, Rahman NE, Bai C, Chen W, Jiang SY, Ramachandran S, Chua NH. 2014. Engineering geminivirus resistance in Jatropha curcus. Biotechnology for biofuels 7:149.

8. Ye J, Geng Y, Zhang B, Mao H, Qu J, Chua N. 2014. The Jatropha FT ortholog is a systemic signal regulating growth and flowering time. Biotechnology for biofuels 7:19.

9. Ye J, Liu P, Zhu C, Qu J, Wang X, Sun Y, Sun F, Jiang Y, Yue G, Wang C. 2014. Identification of candidate genes JcARF19 and JcIAA9 associated with seed size traits in Jatropha. Functional & integrative genomics 14:757-766.

10. Wang G, Sun Y, Xu R, Qu J, Tee C, Jiang X, Ye J. 2014. DNA-A of a highly pathogenic Indian cassava mosaic virus isolated from Jatropha curcas causes symptoms in Nicotiana benthamiana. Virus genes 48:402-405.

Before 2013

11. Wang C, Ye J, Tang W, Liu Z, Zhu C, Wang M, Wan J. 2013. Loop nucleotide polymorphism in a putative miRNA precursor associated with seed length in rice (Oryza sativa L.). International journal of biological sciences 9:578-586.

12. Wang CM, Liu P, Sun F, Li L, Liu P, Ye J, Yue GH. 2012. Isolation and identification of miRNAs in Jatropha curcas. International journal of biological sciences 8:418-429.

13. Qu J#, Ye J#, Geng YF, Sun YW, Gao SQ, Zhang BP, Chen W, Chua NH. 2012. Dissecting functions of KATANIN and WRINKLED1 in cotton fiber development by virus-induced gene silencing. Plant physiology 160:738-748.

14. Ye J*, Hong Y, Qu J, Wang C. 2012. Improvement of Jatropha oil by genetic transformation. Jatropha, Challenges for a New Energy Crop- Genetic Improvement and Biotechnology, vol. 2. Springer Science Publishers, New York.

15. Qu J, Mao HZ, Chen W, Gao SQ, Bai YN, Sun YW, Geng YF, Ye J*. 2012. Development of marker-free transgenic Jatropha plants with increased levels of seed oleic acid. Biotechnology for biofuels 5:10.

16. Qu J, Ye J, Fang R. 2012. Artificial MicroRNAs for Plant Virus Resistance, Antiviral Resistance in Plants: Methods and Protocols, Methods in Molecular Biology, vol. 894.

17. Sun F, Liu P, Ye J, Lo LC, Cao S, Li L, Yue GH, Wang CM. 2012. An approach for jatropha improvement using pleiotropic QTLs regulating plant growth and seed yield. Biotechnology for biofuels 5:42.

18. Gao S, Qu J, Chua NH, Ye J*. 2010. A new strain of Indian cassava mosaic virus causes a mosaic disease in the biodiesel crop Jatropha curcas. Archives of virology 155:607-612.

19. Ye J, Qu J, Zhang JF, Geng YF, Fang RX. 2009. A critical domain of the Cucumber mosaic virus 2b protein for RNA silencing suppressor activity. FEBS letters 583:101-106.

20. Ye J, Qu J, Bui HT, Chua NH. 2009. Rapid analysis of Jatropha curcas gene functions by virus-induced gene silencing. Plant biotechnology journal 7:964-976.

21. Qu J#, Ye J#, Fang R. 2007. Artificial microRNA-mediated virus resistance in plants. Journal of virology 81:6690-6699.

22. Xu Y#, Ye J#, Liu H, Cheng E, Yang Y, Wang W, Zhao M, Zhou D, Liu D, Fang R. 2008. DNA-templated CMV viral capsid proteins assemble into nanotubes. Chemical Communications 1:49-51.

23. Ye J#, Liu L#, Xue Y, Qu J, Gao G, Fang R. 2007. Efficient depletion of multiple SARS-CoV mRNAs by a single small interfering RNA targeting the leader sequence. Progress in Biochemistry and Biophysics 34:1092-1100.

PCT patents applications

1. Jian Ye, et al.Transcriptome and functional analysis reveals a single gene hybrid vigor for oil yield in oil palm.

2. Nam-Hai Chua, Jing Qu, Jian Ye. A method to enhance plant virus resistance.

3. Jian Ye, Jing Qu, Nam-Hai Chua and Shi-Qiang Gao. Control of pests in plants.

4. Jian Ye, Nam-Hai Chua, Jing Qu, Yunfeng Geng and Yunping Bu. Virus induced gene silencing (VIGS) for functional analysis of genes in cotton.

5. Jian Ye, Nam-Hai Chua and Jing Qu. Functional analysis of Jatropha curcas genes.

6. Huizhu Mao, Jian Ye and Nam-Hai Chua. Genetic Transformation of Jatropha curcas.

7. Nam-Hai Chua, Jian Ye and Jing Qu. Increasing cotton fiber length by manipulating transcription factor.

8. Jian Ye, Jing Qu and Huizhu Mao. Microsomal ω6 Oleate Desaturases.

9. Nam-Hai Chua, Yunfeng Geng, Jian Ye Flowering modification in the palm family.

10. Nam-Hai Chua, Jian Ye, Jing Qu, Yanwei Sun (2012). Methods to improve oil trait by manipulation of JcWRI1-like protein.

11. Jian Ye, Jing Qu, Nam-Hai Chua and Shi-Qiang Gao.Control of Pests In Plants.

Representative pictures

1. Geminivirus hijacks host cytosol RNA decay to promote virus replication (Ye* et al. PLoS Pathogens 2015).

2. How Viruses Hijack Plants To Attract Pests