Title: Polysaccharides and biofilms of Pseudomonas aeruginosa

Presenter: Prof. Daniel J. Wozniak

University: Microbiology Center for Microbial Interface Biology, Department of Microbial Infection and Immunity, The Ohio State University

Time: 10:00-11:30, September 17, 2012

Venue: Room A102, Institute of Microbiology, Chinese Academy of Sciences

Introduction & Abstract:

Dr. Wozniak’s research activities are focused on the pathogenesis of several bacteria that cause chronic, devastating infections in humans. In chronic airway infections and wounds, Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter are the most common nosocomial pathogens isolated and consistently associated with high mortality rates. These infections are extremely difficult to control since the bacteia exhibit a biofilm-mode of growth rendering them resistant to antimicrobials and phageocytic cells. Dr. Wozniak’s research activities are focused on: i.Coordinate regulation of virulence factors that contribute to P.aeruginosa pathogenesis; ii.Role of biofilm matrix components in promoting recalitrance to host derived antimicrobials and cells; iii. Experimental therapeutics for combating persistent biofilm infections; iv.Defining pathoadaptive processses and evolution of bacteria during infection; vi.Development of chronic animal models of infection that reproduce human disease.

His talk will be focused on biofilm matrix polysaccharide: its transcriptional regulation and effects on human innate immun system.