Title: mTOR regulation in cell motility and cancer

Presenter: Shile Huang, Associate Professor

University: Department of Biochemistry and Molecular Biology, Louisiana State University

Time: 10:00-11:00, 30 May, 2011

Venue: A202, Institute of Microbiology, Chinese Academy of Sciences

Abstract:

The mammalian target of rapamycin (mTOR) functions in cells at least as two complexes, mTORC1 and mTORC2. Intensive studies have focused on the roles of mTOR in the regulation of cell growth, proliferation, and survival. Recently, we and others have found that mTOR regulates cell motility as well. Both mTORC1 and mTORC2 are involved in the regulation of IGF-I-stimulated cell motility and F-actin reorganization. S6K1, but not 4E-BP1 pathway, participates in the regulation of IGF-I-stimulated phosphorylation of FAK and paxillin. mTOR controls cell motility, also in part by mediating PP2A-Erk1/2 pathway, and by regulating protein expression and activities of the small GTPases.