Presentor:Professor Wei Xiao
Time: 09:30am, June 8，2009
Place: A102, IMCAS
Host/Hostess: Prof. Li Huang Abstract: Ubiquitin (Ub) is an abundant and highly-conserved small protein found in all eukaryotic cells, from unicellular yeasts to human. Ub is attached to the target protein with the help of an Ub conjugating enzyme (E2 or Ubc) and an Ub ligase (E3). Our conventional understanding of ubiquitination is to target protein for degradation as an important means of regulation; however, it becomes increasingly clear that Ub can also be utilized to modify target proteins through different conformations and that at least some of them serve to alter target protein activities instead of their destruction. Here I will present date obtained from my laboratory as well as others on how these unconventional ubiquitination processes serve as newly discovered regulatory mechanisms in eukaryotic cellular responses to environmental stresses, with emphasis on the DNA damage response.
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