Institute of Microbiology, Chinese Academy of Sciences

Scientists

MA LuYan

Professor

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：+86（10）64807437

E-mail：luyanma27@im.ac.cn

Research Areas Experience Publications

Research Areas

Bacterial Biofilm

Experience

1996-1998    Assistant professor/Instructor    China Agricultural University, Beijing, China
1999-2002    Associate Professor    Department of Microbiology, China Agricultural University, Beijing, China
2000-2004    Visiting scholar    Department of Microbiology, University of Connecticut Health Center, Farmington, CT, USA
2005-2008    Research Associate    Wake Forest University Medical School, Winston-Salem, NC, USA
2008-2010    Research Scientist, Center for Microbial Interface Biology the Ohio State University Medical School, Columbus, OH, USA
2010-Present    Professor Institute of Microbiology, Chinese Academy of Sciences, Beijing, P.R. China

Publications

1. Yu Z, Wu Z, Liu D, Liu H, Zhang Y, Zheng Y, Huang Y, Liao S, Wei Y, Huang W, Zhang Z, Liu X, Yu H, Wang D, Li L, Long F*, Ma LZ* (2025) Dual-function regulator MexL as a target to control phenazines production and pathogenesis of Pseudomonas aeruginosa. Nat Commun. 16(1):2000 doi:101038/s41467-025-57294-8.
2. Zhao T, Lei F, Zhang Z, Wang D*, Ma LZ* (2025) Extracellular aminopeptidase regulates exopolysaccharide production of Pseudomonas aeruginosa via quorum sensing. ISME J. doi:101093/ismejo/wraf038.
3. Xie W, Gao X, Zheng M, Tan Z, Liu Y, Ma LZ*, Liu Z*. (2025) The novel Dirammox process for advanced nitrogen removal from high COD content and ammonium-rich wastewater. Environ Technol Inno. 37:103960.
4. Zhao M, Zhang Y, Wang M, Ma LZ* (2024) dsAMP and dsAMPGAN: Deep Learning Networks for Antimicrobial Peptides Recognition and Generation. Antibiotics (Basel).13(10)doi:103390/antibiotics13100948.
5. Shi H, Gong C, Zheng M, Zhao Y, Liu Y, Ma L*, Liu Z*. (2024) Arsenic Enhances the Degradation of Middle-Chain Petroleum Hydrocarbons by Rhodococcus sp. 2021 Under Their Combined Pollution. Microorganisms. 12(11):2279.
6. Zhang H, Zhang W, Zong Y, Kong D, Ma L*, Wu X-L*, Zhao K*. (2024) Dynamics of microbial-induced oil degradation at the microscale. Microbiol Spectr. 12(12):e0117624.
7. Wang D#, Syed Tatheer Alam N#, Lei F#, Zhang Z, Yu H, Ma LZ.* (2023) Glycosyl hydrolase from Pseudomonas fluorescens inhibits the biofilm formation of Pseudomonads. Biofilm. 16;6:100155.
8. Liu D, Wang D, Wei Q, Zhang Y, Yu H, Ma LZ* (2023) A Library of Promoter-gfp Fusion Reporters for Studying Systematic Expression Pattern of Cyclic-di-GMP Metabolism-Related Genes in Pseudomonas aeruginosa. Appl Environ Microbiol. 28;89(2):e0189122.
9. Zhang Y#, Pramod B#, Dinesh SR#, Liu D#, Yu Z#, Zhao T, Zheng Y, Amit K, Yu H, Ma LZ* (2023) Dual functions: A coumarin–chalcone conjugate inhibits cyclic-di-GMP and quorum-sensing signaling to reduce biofilm formation and virulence of pathogens. mLife. 10:1022.
10. Zhang Y#, Zhou C#, Zhou Y#, Zheng Y#, Yu Y, Yang K, Chen Z, Chen X, Wen K, Chen Y, Bai S, Song J, Wu T, Lei E, Wan M, Cai Q*, Ma L*, Wong WL*, Bai Y*, Zhang C*, Feng X* (2023) Amphiphilic Nano-Swords for Direct Penetration and Eradication of Pathogenic Bacterial Biofilms. ACS Appl Mater Interfaces. 15(16):20458-20473.
11. Ma LZ, Wang D, Liu Y, Zhang Z, Wozniak D. (2022) Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa. Annu Rev Microbiol. 76:413-433 doi: 101146/annurev-micro-041320-111355.
12. Zhang J#, Wu H#, Wang D#, Wang L, Cui Y, Zhang C, Zhao K*, Ma LZ* (2022) Intracellular glycosyl hydrolase PslG shapes bacterial cell fate, signaling, and the biofilm development of Pseudomonas aeruginosa. eLife.11:e72778 doi: 107554/eLife72778.
13. Xu A, Wang D, Wang Y, Zhang L, Xie Z, Cui Y, Bhamse P, Yu H, Zhang XX, Li D, Ma LZ* (2022) Mutations in surface-sensing receptor WspA lock the Wsp signal transduction system into a constitutively active state. Environ Microbiol. 24(3):1150-1165 doi: 101111/1462-292015763.
14. Zheng Y, Wang D, Ma LZ. (2021) Effect of Polyhexamethylene Biguanide in Combination with Undecylenamidopropyl Betaine or PslG on Biofilm Clearance. Int J Mol Sci. 22(2):768 doi:103390/ijms22020768.
15. Xu A#, Wang D #, Ding Y, Zheng Y, Wang B, Wei Q, Wang S, Yang L and Ma LZ* (2020) Integrated comparative genomic analysis and phenotypic profiling of Pseudomonas aeruginosa isolates from crude oil. Front Microbiol. 11:519.
16. Xu A, Zhang M, Du W, Wang D* and Ma LZ* (2020) A molecular mechanism for how sigma factor AlgT and transcriptional regulator AmrZ inhibit twitching motility in Pseudomonas aeruginosa. Environ Microbiol. doi:101111/1462-292014985.
17. Wei Q, Bhasme P, Wang Z, Wang L, Wang S, Zeng Y, Wang Y, Ma LZ *and Li Y* (2020) Chinese medicinal herb extract inhibits PQS-mediated quorum sensing system in Pseudomonas aeruginosa. J Ethnopharmacol. 248, 112272.
18. Bhasme P, Wei Q, Xu A, Naqvi S, Wang D and Ma LZ * (2020) Evaluation and characterization of the predicted diguanylate cyclase-encoding genes in Pseudomonas aeruginosa. MicrobiologyOpen, 9(3): e975.
19. Zhao T, Zhang J, Tang M, Ma LZ* and Lei X.* (2019) Development of an effective fluorescence probe for discovery of aminopeptidase inhibitors to suppress biofilm formation. J Antibiot, 72, 461-468.
20. Wu H, Wang D, Tang M, and Ma LZ. * (2019) The advance of assembly of exopolysaccharide Psl biosynthesis machinery in Pseudomonas aeruginosa. MicrobiologyOpen, 8(10): e857.
21. Wu H, Qiao S, Li D, Guo L, Zhu M and Ma LZ * (2019) Crystal structure of the glycoside hydrolase PssZ from Listeria monocytogenes. Acta Crystallogr F, Structural Biology Communications, 75, 501-506.
22. Wei Q, Leclercq S, Bhasme P, Xu A, Zhu B, Zhang Y, Zhang M, Wang S and Ma LZ * (2019) Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses. Appl Environ Microbiol, 16;85(21) pii: e01194-19.
23. Liu X, Wang S, Xu A, Zhang L, Liu H and Ma LZ * (2019) Biological synthesis of high-conductive pili in aerobic bacterium Pseudomonas aeruginosa. Appl Microbiol Biotechnol, 103, 1535-1544.
24. Zhao, T, Zhang, Y, Wu, H, Wang, D, Chen, Y, Zhu, MJ and Ma, LZ * (2018) Extracellular aminopeptidase modulates biofilm development of Pseudomonas aeruginosa by affecting matrix exopolysaccharide and bacterial cell death. Environ Microbiol Rep, 10, 583-593.
25. Yu S, Zhang M and Ma L* (2017) Anti-biofilm effects of Zn lactate3H(2)O and SnF(2) on Pseudomonas aeruginosa, Acinetobacter baumannii and Streptococcus mutans. Sheng wu gong cheng xue bao = Chinese Journal of Biotechnology, 33, 1478-1488.
26. Yu S and Ma L * (2017) Iron uptake and biofilm formation in Pseudomonas aeruginosa. Sheng wu gong cheng xue bao = Chinese Journal of Biotechnology, 33, 1489-1512.
27. Wang D, Xu A, Elmerich C and Ma LZ * (2017) Biofilm formation enables free-living nitrogen-fixing rhizobacteria to fix nitrogen under aerobic conditions. ISME J, 11, 1602-1613.
28. Zhu B, Liu C, Liu S, Cong H, Chen Y, Gu L and Ma LZ* (2016) Membrane association of SadC enhances its diguanylate cyclase activity to control exopolysaccharides synthesis and biofilm formation in Pseudomonas aeruginosa. Environ Microbiol, 18, 3440-3452.
29. Yu S, Wei Q, Zhao T, Guo Y and Ma LZ* (2016) A Survival Strategy for Pseudomonas aeruginosa That Uses Exopolysaccharides To Sequester and Store Iron To Stimulate Psl-Dependent Biofilm Formation. Appl Environ Microbiol, 82, 6403-6413.
30. Yu S #, Su T #, Wu H, Liu S, Wang D, Zhao T, Jin Z, Du W, Zhu MJ, Chua SL Gu L*, Ma, LZ* (2015) PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix. Cell Res, 25, 1352-1367.
31. Wang S, Liu X, Liu H, Zhang L, Guo Y, Yu S, Wozniak DJ and Ma LZ* (2015) The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa. Environ Microbiol Rep, 7, 330-340.
32. Wang D, Hildebrand F, Ye L, Wei Q and Ma LZ* (2015) Genome Sequence of Mucoid Pseudomonas aeruginosa Strain FRD1. Genome Announ, 3.
33. Wang S, Yu S, Zhang Z, Wei Q, Yan L, Ai G, Liu H and Ma LZ* (2014) Coordination of swarming motility, biosurfactant synthesis, and biofilm matrix exopolysaccharide production in Pseudomonas aeruginosa. Appl Environ Microbiol, 80, 6724-6732.
34. Das P, Yang XP and Ma LZ* (2014) Analysis of biosurfactants from industrially viable Pseudomonas strain isolated from crude oil suggests how rhamnolipids congeners affect emulsification property and antimicrobial activity. Front Microbiol, 5, 696.
35. Wei Q and Ma LZ* (2013) Biofilm matrix and its regulation in Pseudomonas aeruginosa. Int J Mol Sci, 14, 20983-21005.
36. Wang S, Parsek MR, Wozniak DJ and Ma LZ* (2013) A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix in Pseudomonas aeruginosa biofilms. Environ Microbiol, 15, 2238-2253.
37. Ma LZ*, Wang S, Wang D, Parsek MR and Wozniak DJ. (2012) The roles of biofilm matrix polysaccharide Psl in mucoid Pseudomonas aeruginosa biofilms FEMS Immuno Med Mic, 65, 377-380
38. Ma LZ*, Wang J, Wang S, Anderson EM, Lam JS, Parsek MR and Wozniak DJ (2012) Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated. Environ Microbiol, 14, 1995-2005.
39. Ma L, Conover M, Lu H, Parsek MR, Bayles K and Wozniak DJ. * (2009) Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathog, 5, e1000354.