Synthetic biology of Microbial Natural Products and New Drug Discovery

2012.10-2016.09:
Ph. D. University of Warwick, United Kingdom.
2009.09-2012.03:
Master Degree. Shanghai Jiao Tong University, Shanghai, China.
2004.09-2008.06:
Bachelor Degree. China Pharmaceutical University, Nanjing, China.

1. Zhou S#, Bhukya H#, Malet NR#, Harrison PJ, Rea D, Belousoff MJ, Venugopal H, Sydor PK, Styles KM, Song L, Cryle MJ, Alkhalaf LM, Fülöp V, Challis GL*, Corre C*. Molecular basis for control of antibiotic production by a bacterial hormone. Nature 2021, 590: 463-467.
2. Zhou S, Malet NR, Song L, Corre C, Challis GL*. MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis. Chem. Commun. 2020, 56: 14443-14446.
3. Kosol S#, Gallo A#, Griffiths D#, Valentic TR#, Masschelein J, Jenner M, de los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fulop V, Oldham NJ, Tsai S-C, Challis GL*, Lewandowski JR*. Structural basis for chain release from the enacyloxin polyketide synthase. Nat. Chem. 2019, 11: 913-923.
4. Zhou S, Song L, Masschelein J, Sumang FAM, Papa IA, Zulaybar TO, Custodio AB, Zabala D, Alcantara EP, de los Santos ELC*, Challis GL*. Pentamycin biosynthesis in Philippine Streptomyces sp. S816: cytochrome P450-catalyzed installation of the C-14 hydroxyl group. ACS Chem. Biol. 2019, 14: 1305-1309.
5. Inahashi Y#, Zhou S#, Bibb MJ, Song L, Al-Bassam MM, Bibb MJ*, Challis GL*. Watasemycin biosynthesis in Streptomyces venezuelae: thiazoline C-methylation by a type B radical-SAM methylase homologue. Chem. Sci. 2017, 8: 2823-2831.
6. Zhou S, Alkhalaf LM, de los Santos ELC, Challis GL*. Mechanistic insights into class B radical-S-adenosylmethionine methylases: Ubiquitous tailoring enzymes in natural product biosynthesis. Curr. Opin. Chem. Biol. 2016, 35: 73-79.
7. Wang R#, Zhang X#, Song H, Zhou S, Li S*. Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents. Bioorg. Med. Chem. Lett. 2014, 24: 4304-4307.
8. Song H, Zhou S, Wang R*, Li S*. Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy. ChemMedChem 2013, 8: 1736-1749.
9. Wang R, Zhou S, Jiang H, Zheng X, Zhou W, Li S*. An efficient multigram synthesis of alkannin and shikonin. Eur. J. Org. Chem. 2012, 7: 1373-1379.
10. Wang R, Zhou S, Li S*. Cancer therapeutic agents targeting hypoxia-inducible factor-1. Curr. Med. Chem. 2011, 18: 3168-3189.

2021, Faculty of Science, Engineering and Medicine Post-Doctoral Research Prize in Chemistry, University of Warwick
2016, EPSRC INTEGRATE AMR Early Career Fellowship