Mechanisms of Gut Microbe-Host Interaction and R&D of Microecological Products

2024 - Present Institute of Microbiology, Chinese Academy of Sciences (IMCAS) Director, Department of Microbiome and Microecological Technology
2011 - 2024 Institute of Microbiology, Chinese Academy of Sciences (IMCAS) Professor, Principal Investigator (Research Group Leader)
2014 - 2019 Institute of Microbiology, Chinese Academy of Sciences (IMCAS) Director, Graduate Student Office / Department
2009 - 2011 Institute of Microbiology, Chinese Academy of Sciences (IMCAS) Associate Professor / Associate Research Fellow
2006 - 2008 Capital Medical University, Beijing Associate Professor
2004 - 2006 Tsinghua University Postdoctoral Researcher / Assistant Research Fellow

1. Shanshan Qiao, Tao Wang, Jingzu Sun, Junjie Han, Huanqin Dai, Mengxuan Du, Lan Yang, ChunJun Guo, Chang Liu, Shuang-Jiang Liu, Hongwei Liu*. Cross-feeding-based rational design of a probiotic combination of Bacterides xylanisolvens and Clostridium butyricum therapy for metabolic diseases. Gut Microbes 2025, 17: 2489765.
2. Ruopeng Yin, Tao Wang, Jingzu Sun, Huanqin Dai, Yuting Zhang, Ningning Liu, Hongwei Liu*. Postbiotics from Lactobacillus johnsonii activates gut innate immunity to mitigate alcohol-associated liver disease, Advanced Science, 2024, 12: 2405781.
3. Chang Liu, Meng-Xuan Du, Li-Sheng Xie, Wen-Zhao Wang, Bao-Song Chen, Chu-Yu Yun, Xin-Wei Sun, Xi Luo, Yu Jiang, Kai Wang, Min-Zhi Jiang, Shan-Shan Qiao, Min Sun, Bao-Juan Cui, Hao-Jie Huang, Shu-Ping Qu, Chang-Kun Li, Dalei Wu, Lu-Shan Wang, Changtao Jiang*, Hong-Wei Liu*, Shuang-Jiang Liu*，Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids. Nature Microbiology, 2024, 9: 434-450.
4. Dawei Chen, Zhijun Song, Junjie Han, Jimei Liu, Hongwei Liu*, Jungui Dai*. Targeted discovery of glycosylated natural products by tailoring enzyme-guided genome mining and MS-based metabolome analysis. Journal of the American Chemical Society, 2024, 146 (14): 9614-9622.
5. Zi-lin Si, Han-yu Wang, Tao Wang, Yi-zhi Cao, Qing-zhen Li, Kang Liu, Zhou Huang, Hui-ling Liu, Ya-jie Tan, Yin-yin Wang, Feng-qing Huang, Gao-xiang Ma, Raphael N. Alolga, Miao Yan, Cheng Chen, Jun-hui Li, Jing Li*, Hong-wei Liu*, Zhi-hao Zhang*. Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens, Cell Reports, 2024, 43(10): 114830.
6. Ruopeng Yin, Tao Wang, Huanqin Dai, Junjie Han, Jingzu Sun, Ningning Liu, Wang Dong, Jin Zhong, Hongwei Liu*. Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms. Protein & Cell. 2023, 14(10): 776-785.
7. Huanqin Dai, Han Junjie, Tao Wang, Wen-Bing Yin, Yihua Chen, Hongwei Liu*. Recent advances in gut microbiota-associated natural products: structures, bioactivities, and mechanisms. Natural Product Reports. 2023, 40 (6): 1078-1093
8. Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huanqin Dai, Kai Wang, Li Bao, Hantian Li, Wenzhao Wang, Shuang-Jiang Liu, Hongwei Liu*. Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism. Nature Metabolism. 2022, 4(10): 1271-1286.
9. Tao Wang, Junjie Han, Huanqin Dai, Jingzu Sun, Jinwei Ren, Wenzhao Wang, Shanshan Qiao, Chang Liu, Li Sun, Shuangjiang Liu, Dianpeng Li, Shenglong Wei, Hongwei Liu*. Polysaccharides from Lyophyllum decastes reduce obesity by altering gut microbiota and increasing energy expenditure. Carbohydrate Polymers. 2022, 295: 119862.
10. Ke Ma, Yuting Zhang, Cui Guo, Yanlong Yang, Junjie Han, Bo Yua, Wenbing Yin, Hongwei Liu*. Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues. Acta Pharmaceutica Sinica B, 2021, 11(9): 2945-2956.
11. Shanshan Sun, Kai Wang, Li Sun, Baosong Cheng, Shanshan Qiao, Huanqin Dai, Wenyu Shi, Juncai Ma, Hongwei Liu*. Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE2 to alcoholic hepatic steatosis. Gut Microbes, 2020, 12(1): 1830693.
12. Shanshan Qiao, Li Bao, Kai Wang, Shanshan Sun, Mingfang Liao, Chang Liu, Nan Zhou, Ke Ma, Yuwei Zhang, Yihua Chen, Shuang-Jiang Liu*, Hongwei Liu*. Activation of a specific gut Bacteroides-folate-liver axis benefits for the alleviation of nonalcoholic hepatic steatosis. Cell Reports, 2020, 32(6): 108005.
13. Chang Liu, Nan Zhou, Mengxuan Du, Yutong Sun, Kai Wang, Yujing Wang, Danhua Li, Haiying Yu, Yuqin Song, Bingbing Bai, Yuhua Xin, Linhuan Wu, Chengying Jiang, Jie Feng, Hua Xiang, Yuguang Zhou, Juncai Ma, Jun Wang, Hongwei Liu,* Shuangjiang Liu.* The mouse gut microbial biobank expands the coverage of cultured bacteria. Nature Communications, 2020, 11: 79.
14. Kai Wang, Mingfang Liao, Nan Zhou, Li Bao, Ke Ma, Zhongyong Zheng, Yujing Wang, Chang Liu, Wenzhao Wang, Jun Wang, Shuangjiang Liu*, Hongwei Liu*. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Reports, 2019, 26(1): 222-235.e5.
15. Yanlong Yang, Shasha Zhang, Ke Ma, Yuxing Xu, Qiaoqiao Tao, Yihua Chen, Juan Chen, Shunxing Guo, Jinwei Ren, Wenzhao Wang, Yong Tao, Wenbing Yin, Hongwei Liu*. Discovery and characterization of the UbiA proteins as a new family of diterpene cyclases in bacteria and fungi. Angewandte Chemie International Edition, 2017, 56(7): 4749-4752.

1. 2023 The First Prize of Henan Province Science and Technology Progress Award
2.The 2021 "Zhu Liyuehua" Outstanding Teacher Award of the Chinese Academy of Sciences 3.2021 University of Chinese Academy of Sciences "Leading Goose Silver Award"  
4. 2021 The "Dean's Teaching Award" Special Prize of the Institute of Microbiology, Chinese Academy of Sciences
5. 2020 The "Outstanding Mentor Award" of the Chinese Academy of Sciences  
6. 2020 Second Prize for Teaching Achievements of China University of Science and Technology (Collective Award, Main Contributors)
7. 2020 Special Government Merit Expert of the State Council.
8. Provincial and Ministerial-level Award: National Thousand-Talents Program - Young and Middle-aged Experts with Outstanding Contributions.
9.First Prize of Science and Technology of the Tibet Autonomous Region.