Principal Investigator,Professor : Genome mining; Bioinformatics research
Development of metagenomic technologies and methods for analyzing microbial communities.
● Single-cell metagenomic detection and library construction technology for precision sampling in microbial resource.
● Precision medicine analysis toolkit for better understanding of the correlation between metabolism network, colony evolution and the clinical phenotypes.
Construction of comprehensive bioinformatic platform for microbial multi-omics data.
● Microbial genomics comprehensive analysis platform for multi-source omics data from human, animals and plants.
● Tracking database for metadata of samples and workflows, which enables long-term tracking and multidimensional comparison.
Bioinformatic datamining and utilizing of microbial genome resources.
1. Li, C., Song, W., Luo, Y., Gao, S., Zhang, R., Shi, Z., Wang, X., Wang, R., Wang, F., Wang, J., Zhao, Y., Su, A., Wang, S., Li, X., Luo, M., Wang, S., Zhang, Y., Ge, J., Tan, X., Yuan, Y., Bi, X., He, H., Yan, J., Wang, Y., Hu, S*. & Zhao, J. The HuangZaoSi maize genome provides insights into genomic variation and improvement history of maize. Molecular Plant12, 402-409, doi:10.1016/j.molp.2019.02.009 (2019).
2. Subramanian, B., S. Gao, M. J. Lercher, S. Hu* and W. H. Chen*, Evolview v3: a webserver for visualization, annotation, and management of phylogenetic trees. Nucleic Acids Res, 2019. 47(W1): p. W270-W275.
3. Tang, C*., M. Yang, Y. Fang, Y. Luo, S. Gao, X. Xiao, Z. An, B. Zhou, B. Zhang, X. Tan, H. Y. Yeang, Y. Qin, J. Yang, Q. Lin, H. Mei, P. Montoro, X. Long, J. Qi, Y. Hua, Z. He, M. Sun, W. Li, X. Zeng, H. Cheng, Y. Liu, J. Yang, W. Tian, N. Zhuang, R. Zeng, D. Li, P. He, Z. Li, Z. Zou, S. Li, C. Li, J. Wang, D. Wei, C. Q. Lai, W. Luo, J. Yu, S. Hu* and H. Huang*, The rubber tree genome reveals new insights into rubber production and species adaptation. Nat Plants, 2016. 2(6): p. 16073.
4. Wang, S., Wang, S., Luo, Y., Xiao, L., Luo, X., Gao, S., Dou, Y., Zhang, H., Guo, A., Meng, Q., Hou, J., Zhang, B., Zhang, S., Yang, M., Meng, X., Mei, H., Li, H., He, Z., Zhu, X., Tan, X., Zhu, X.-Q., Yu, J., Cai, J., Zhu, G., Hu, S*. & Cai, X. Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nature communications7, 12845, doi:10.1038/ncomms12845 (2016).
5. He, Z., H. Zhang, S. Gao, M. J. Lercher, W. H. Chen* and S. Hu*, Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees. Nucleic Acids Res, 2016. 44(W1): p. W236-41.
6. Dai, X., Y. Tian, J. Li, Y. Luo, D. Liu, H. Zheng, J. Wang, Z. Dong, S. Hu* and L. Huang*,Metatranscriptomic analyses of plant cell wall polysaccharide degradation by microorganisms in the cow rumen. Appl Environ Microbiol, 2015. 81(4): p. 1375-86.