Principal Investigators
State Key Laboratory of Microbial Resources
State Key Laboratory of Mycology
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
CAS Key laboratory of Pathogenic Microbiology & Immunology
The Center for Microbial Resource and Big Data-
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
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CAS Member : Regulation of Gene Expression and Plant Biotechnology

FANG Rongxiang (Professor)
Title：Member of the CAS; Professor and Director of The Department of Agricultural Microbiology and Biotechnology; Principal Investigator of Regulation of Gene Expression and Plant Biotechnology Group
Dept.: Agricultural Microbiology & Biotechnology; State Key Laboratory of Plant GenomicsDept.: Agricultural Microbiology & Biotechnology; State Key Laboratory of Plant Genomics
Address：Room 318 Building 1, Institute of Genetics & Developmental Biology, Chinese Academy of Sciences, No.2 Yard 1 West Beichen Road, Chaoyang District, Beijing 100101, P.R. China
Telephone/fax：+86-10-64858245
Fax:+86-10-64858245
E-mail：fangrx@im.ac.cn
Background
Prof. Fang was born in Shanghai, graduated from Department of Chemistry, Fudan University in 1967. He was the director of IMCAS from 2000 to 2004 and elected a member of Chinese Academy of Sciences in 2003 and a member of the Academy of Sciences for the Developing World (TWAS) in 2007. So far, he has published more than 80 papers. Selected papers are below.
International Experiences:
1979-1981 Visiting Scholar in Laboratory of Molecular Biology,
The State University of Ghent, Belgium.
1985-1988 Visiting Scientist in Laboratory of Plant Molecular Biology,
The Rockefeller University, USA.
1989-1995 Rockefeller Foundation Biotechnology Career Fellowship.
Research Interests
1. Plant virology
2. Plant pathogen-host interactions
3. Disease-resistant transgenic plants and plant bioreactors
Awards

Year

Awards and Honors Title

Quantity

2005

Science and Technology Advancement Prize awarded by The Holeung Ho Lee Foundation

 

1994

Young and Middle-aged expert with Outstanding Contributions titled by Ministry of Personnel

l

1993

Science and Technology Advancement Prize first-class awarded by Chiense Academy of Sciences

1

1993

Science and Technology Advancement Prize first-class awarded by Henan Province

1

1991

Science and Technology Advancement Prize first-class awarded by Chiense Academy of Sciences

1

1990

Science and Technology Advancement Prize Second-class awarded by Chiense Academy of Sciences

1

1987

Science and Technology Advancement Prize Second-class awarded by Chiense Academy of Sciences

2

Publication
Selected Publications:
[1] Zhang Jingxi, Kan Jinhong, Zhang Jieqiong, Guo Ping, Chen Xiaoying, Fang Rongxiang*, and Jia Yantao*. 2012. Synergistic Activation of the Pathogenicity-Related Proline Iminopeptidase Gene in Xanthomonas campestris pv. campestris by HrpX and a LuxR Homolog. Applied and Environmental Microbiology 78: 7069-7074.
[2] Lina Wang#,Yunfeng Liu#, Yuman Zhang*, Rongxiang Fang, Qinglin Liu*. The Expression level of Rosa Terminal Flower 1 (RTFL1) is related with recurrent flowering in Roses. Molecular Biology Reports  39: 3737-3746, 2012
[3] Sadia Hamera, Xiaoguang Song, Lei Su, Xiaoying Chen*, Rongxiang Fang*. 
Cucumber Mosaic Virus suppressor 2b binds to AGO4-related small RNAs and impairs AGO4 activities. 
The Plant Journal  69: 104-115, 2012
[4] Yuman Zhang, Yongsheng Yan, Lina Wang, Kun Yang, Na Xiao, Yunfeng Liu, Yaping Fu, Zongxiu Sun, Rongxiang Fang and Xiaoying Chen*.
A novel rice gene, NRR responds to macronutrient deficiency and regulates root growth.
Molecular Plant 5: 63-72, 2012
[5] Yuman Zhang, Yumei Zheng, Na Xiao, Lina Wang, Yao Zhang, Rongxiang Fang, Xiaoying Chen*. 
Functional analysis of the HS185 regulatory element in the rice HSP70 promoter.
Molecular Biology Reports  39: 1649-1657, 2012
[6] Hui Zhu, Chengguo Duan, Weina Hou, Quansheng Du, Dianqiu Lv, Rongxiang Fang and Huishan Guo*
Satellite RNA-derived satsiR-12 targeting the 3' UTR of Cucumber mosaic virus triggers viral RNAs for degradation
Journal of Virology  85: 13384-13397, 2011
[7] Weina Hou#,Chengguo Duan#, Rongxiang Fang, Xiaoyang Zhou*, Huishan Guo*
Satellite RNA reduces expression of the 2b suppressor protein resulting in the attenuation of symptoms caused by Cucumber mosaic virus infection. 
Molecular Plant Pathology  12: 595-605, 2011
[8] Hong Liang, Ying-Tao Zhao, Jie-Qiong Zhang, Xiu-Jie Wang, Rong-Xiang Fang*, Yan-Tao Jia*
Identification and functional characterization of small non-coding RNAs in Xanthomonas oryzae pathovar oryzae
BMC Genomics  12: 87, 2011
[9] Yanmei Yang, Xia Li, Hui Yang, Yuan Qian, You Zhang, Rongxiang Fang* and Xiaoying Chen*. 
Immunogenicity and virus-like particle formation of Rotavirus capsid proteins produced in transgenic plants.
Science in China (Series C)  54: 82-89, 2011
[10] Yongsheng Yan, Xiaoying Chen, Kun Yang, Zongxiu Sun, Yaping Fu, Yuman Zhang*, Rongxiang Fang*. 
Over-expression of an F-box protein gene reduces abiotic stress tolerance and promotes root growth in rice. 
Molecular Plant  4: 190-197, 2011
[11] Yongsheng Yan, Yuman Zhang, Kun Yang, Zongxiu Sun, Yaping Fu, Xiaoying Chen* and Rongxiang Fang*.
Small RNAs from MITE-derived stem-loop precursors regulate ABA signaling and abiotic stress responses in rice. 
The Plant Journal  65: 820-828, 2011
[12] Li Wang, Lili Zhang, Yunfeng Geng, Wei Xi, Rongxiang Fang*, Yantao Jia*
XerR, a negative regulator of XccR in Xanthomonas campestris pv. campestris, relieves its repressor function in planta
Cell Research  21:1131-1142, 2011.
[13] Xiaobao Ying, Li Dong, Hui Zhu, Chengguo Duan, Quansheng Du, Dianqiu Lv, Yuanyuan Fang, Juan Antonio Garcia, Rongxiang Fang and Huishan Guo*
RNA-Dependent RNA Polymerase 1 from Nicotiana tabacum Suppresses RNA Silencing and Enhances Viral Infection in Nicotiana benthamiana
The Plant Cell  22: 1358-1372, 2010.
[14] Fujie Zhang, Hongyan Guo, Huajun Zheng, Tong Zhou, Yijun Zhou, Shengyue Wang, Rongxiang Fang, Wei Qian*, Xiaoying Chen*
Massively parallel pyrosequencing-based transcriptome analyses of small brown planthopper (Laodelphax striatellus), a vector insect transmitting rice stripe virus (RSV)
BMC Genomics  11:303, 2010 (http://www.biomedcentral.com/1471-2164/11/303).
[15] JianYe, Jing Qu, Jianfeng Zhang, Yunfeng Geng and Rongxiang Fang*.
A critical domain of the Cucumber mosaic virus 2b protein for RNA silencing suppressor activity. 
FEBS Letters   583: 101-106, 2009.
[16] Yanmei Li, Zhongkai Zhang, Yantao Jia, Yuemao Shen, Hongping He, Rongxiang Fang, Xiaoying Chen* and Xiaojiang Hao*. 
3-acetonyl-3-hydroxyoxindole: a new inducer of systemic acquired resistance in plants. 
Plant Biotechnology Journal   6: 301-308, 2008.
[17] ChengGuo Duan, ChunHan Wang, RongXiang Fang, HuiShan Guo*. 
Artificial MicroRNAs Highly Accessible to Targets Confer Efficient Virus resistance in Plants.
Journal of Virology   82: 11084-11095, 2008.
[18] Yun Xu, Jian Ye#, Huajie Liu, Enjun Cheng, Yang Yang, Wenxing Wang, Manchun Zhao, Dejian Zhou, Dongsheng Liu* and Rongxiang Fang.
DNA-templated CMV viral capsid proteins assemble into nanotubes.
Chemical Communications   1: 49-51, 2008.
[19] Quansheng Du, Chengguo Duan, Zhong-Hui Zhang, Yuanyuan Fang, Rongxiang Fang, Qi Xie, and Huishan Guo*.
DCL4 targets Cucumber mosaic virus satellite RNA at novel secondary structures.
Journal of Virology   81: 9142-9151, 2007.
[20] Yanmei Li, Yantao Jia, Zhongkai Zhang, Xiaoying Chen, Hongping He, Rongxiang Fang* and Xiaojiang Hao*.
Purification and characterization of a new ribosome inactivating protein from cinchonaglycoside C-treated tobacco leaves.
Journal of Integrative Plant Biology  49: 1327-1333, 2007.
[21] Jian Ye, Lixin Liu, Yuan Xue, Jing Qu, Guangxia Gao* and Rongxiang Fang*.
Efficient depletion of multiple SARS-CoV mRNAs by a single small interfering RNA targeting the leader sequence. 
Progress in Biochemistry and Biophysics  34: 1092-1100, 2007.
[22] Lei Su, Shang Gao, Yanwei Huang, Chaoqun Ji, Dickson Wang, Yun Ma, Rongxiang Fang and Xiaoying Chen*.
Complete genomic sequence of Dracaena mottle virus, a distinct badnavirus.
Virus Genes  35: 423-429, 2007.
[23] Jing Qu, Jian Ye and Rongxiang Fang*.
Artificial MicroRNA-Mediated Virus Resistance in Plants.
Journal of Virology  81: 6690-6699, 2007.
[24] Lili Zhang, Yantao Jia, Li Wang and Rongxiang Fang*.
A proline iminopeptidase gene upregulated in planta by a LuxR homologue is essential for pathogenicity of Xanthomonas campestris pv. campestris.
Molecular Microbiology  65: 121-136, 2007.
[25] Yanmei Li, Lihua Wang, Shunlin Li, Xiaoying Chen, Yuemao Shen, Zhongkai Zhang, Hongping He, Wenbo Xu, Yuelong Shu, Guodong Liang, Rongxiang Fang*, and Xiaojiang Hao*.
Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses.
Proc. Natl. Acad. Sci. USA  104: 8083-8088, 2007.
[26] Hongge Jia, Yongqin Pang, Xiaoying Chen*, Rongxiang Fang. 
Removal of the selectable marker gene from transgenic tobacco plants by expression of Cre recombinase from a Tobacco Mosaic Virus vector through agroinfection. 
Transgenic Research  15: 375-384, 2006.
[27] Qihong Sun, Jun Hu, Guixiu Huang, Chao Ge, Rongxiang Fang and Chaozu He*.
Type II secretion pathway structural gene xpsE is required for xylanase- and cellulase- secretion and virulence in Xanthomonas oryzae pv. oryzae.
Plant Pathology  54: 15-21, 2005.
[28] Wei Qian, Yantao Jia, Shuang-Xi Ren, Yong-Qiang He, Jia-Xun Feng, Ling-Feng Lu, Qihong Sun, Ge Ying, Dong-Jie Tang, Hua Tang, Wei Wu, Pei Hao, Lifeng Wang, Bo-Le Jiang, Shenyan Zeng, Wen-Yi Gu, Gang Lu, Li Rong, Yingchuan Tian, Zhijian Yao, Gang Fu, Baoshan Chen, Rongxiang Fang, Boqin Qiang, Zhu Chen, Guo-Ping Zhao, Ji-Liang Tang, and Chaozu He.
Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris.
Genome Research  15: 757-767, 2005.
[29] Y.W. Huang, Y.F. Geng, X.B. Ying, X.Y. Chen and R.X. Fang*.
Identification of a movement protein of rice yellow stunt rhabdovirus.
Journal of Virology  79: 2108-2114, 2005.
[30] H.N.Guo, X.Y.Chen, H.L.Zhang, R.X.Fang, Z.Q.Yuan, Z.S.Zhang, Y.C.Tian*.
Characterization and activity enhancement of the phloem- specific pumpkin PP2 gene promoter.
Transgenic Research  13: 559-566, 2004.
[31] L.H. Wang, Y.W. He, Y.F. Gao, J.E. Wu, Y.H. Dong, C.Z. He, S.X. Wang, L.X. Weng, J.L. Xu, L. Tay, R.X. Fang and L.H. Zhang*.
A bacterial cell-cell communication signal with cross-kingdom structural analogues.
Molecular Microbiology  51: 903-912, 2004.
[32] Q.H. Sun, W. Wu, W. Qian, J. Hu, R.X. Fang, C.Z. He*.
High-quality mutant libraries of Xanthomonas oryzae pv. oryzae and X. campestris pv. campestris generated by an efficient transposon mutagenesis system.
FEMS Microbiology Letters  226: 145-150, 2003.
[33] Y.W. Huang, H. Zhao, Z.L. Luo, X.Y. Chen and R.X. Fang*.
Novel structure of the Rice yellow stunt nucleorhabdovirus genome: identification of the gene 6-encoded virion protein.
Journal of General Virology  84: 2259-2264, 2003.
[34] H.G. Jia, Y.Q. Pang, R.X. Fang*.
Agroinoculation as a simple way to deliver a tobacco mosaic virus-based expression vector.
Acta Botanica Sinica  45: 770-773, 2003.
[35] Z.Z. Liu, J.L. Wang, Q. Wang, X. Huang, W.H. Xu, L.H. Zhu, P. He and R.X. Fang*.
Structure, expression pattern and chromosomal localization of the rice Osgrp-2 gene.
Science in China  46: 584-594, 2003.
[36] Z.Z. Liu, J.L. Wang, X. Huang, W.H. Xu, Z.M. Liu, R.X. Fang*.
The promoter of a rice glycine-rich protein gene, Osgrp-2, confers vascular-specific expression in transgenic plants.
Planta  216: 824-833, 2003.
[37] W.Q. Cai, R.X. Fang*, H.S. Shang, X. Wang, F.L. Zhang, Y.R. Li, J.C. Zhang, X.Y. Cheng, G.L. Wang, K.Q. Mang.
Development of CMV-and TMV-resistant chili pepper: field performance and biosafety assessment.
Molecular Breeding  11: 25-35, 2003.
[38] Wangli Lei, Rongxiang Fang*, Guohua Zhang, Xiaoying Chen, Xiaoqin Zhang.
ecombination with coat protein transgene in a complementation system based on Cucumber mosaic virus (CMV).
Science in China (Series C)  44: 263-273, 2001.
[39] Xinguo Wang, Guohua Zhang, Chuanxuan Liu, Yanhong Zhang, Chengzu Xiao, Rongxiang Fang*.
Purified cholera toxin B subunit from transgenic tobacco plants possesses authentic antigenicity.
Biotechnology and Bioengineering  72: 490-494, 2001.
[40] Qun Wang, Xiaoying Chen, Zongli Luo and Rongxiang Fang *.
Sequence analysis of leader and trailer regions of rice yellow stunt rhabdovirus and characterization of their in vivo transcripts.
Science in China (C)  42: 50-56, 1999.
[41] Z.L.Luo and R.X.Fang*.
Structure analysis of the rice yellow stunt rhabdovirus glycoprotein gene and its MRNA.
Arch.Virol.  143: 2453-2459, 1998.
[42] Zongli Luo, Xiaoying Chen, Dongming Gao, Rongxiang Fang*.
The gene 4 of rice yellow stunt rhabdovirus encodes the matrix protein.
Virus Genes  16:277-280, 1998.
[43] N.H. Cheng, R.X. Fang*, Z.Q. Pu and Z.D. Fang.
Complete nucleotide sequence of a new satellite RNA associated with cucumber mosaic virus inducing tomato necrosis.
Science in China (Series C)  40: 443-448, 1997.
[44] Q. Wang and R.X. Fang*.
Structure and expression of a rice hsp70 gene.
Science in China (Series C)  39: 291-299, 1996
[45] Rong-Xiang Fang*, Qun Wang, Bing-Yin Xu, Zhen Pang, Hai-Tao Zhu, Ke-Qiang Mang, Dong-Ming Gao and Nam-Hai Chua.
Structure of the nucleocapsid protein gene of rice yellow stunt rhabdovirus.
Virology  204: 367-375, 1994.
[46] Rong-Xiang Fang, Zhen Pang, Dong-Ming Gao, Ke-Qiang Mang and Nam-Hai Chua*.
cDNA sequence of a virus-inducible, glycine-rich protein gene from rice.
Plant Molecular Biology  17: 1255-1257, 1991.
[47] Xue-Rong Zhou, Rong-Xiang Fang*, Cheng-Qiu Wang and Ke-Qiang Mang.
cDNA sequence of the 3’-coding region of PVY genome (the Chinese isolate).
Nucleic Acids Research  18: 5554, 1990.
[48] Ling-Jie Kong, Rong-Xiang Fang*, Zheng-Hua Chen and Ke-Qiang Mang.
Molecular cloning and nucleotide sequence of coat protein gene of turnip mosaic virus.
Nucleic Acids Research  18: 5555, 1990.
[49] R.X. Fang, Y.C. Tian, G.L. Wang, X.F. Qin, M.Z. Yang, T.Y. Li, B.Y. Xu, K.Q. Mang, Z.C. Zhang, Q. Wu, R.H. Zhou, F.L. Wang, G. Zhao and X.D. Han.
Transgenic tobacco plants resistant to infection of both tobacco mosaic virus and cucumber mosaic virus.
Chinese Science Bulletin  36: 524-525, 1990.
[50] E. Lam, P. Benfey, P. Gilmartin, R-X. Fang, N-H. Chua.
Site- specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants.
Proc. Natl. Acad. Sci. USA  86: 7890-7894, 1989.
[51] R-X. Fang, F. Nagy, S.Sivasubramaniam, N-H. Chua*.
Multiple cis-regulatory elements for maximal expression of the cauliflower mosaic virus 35S promoter in transgenic plants.
The Plant Cell  1: 141-150, 1989.
[52] C. Hemenway, R-X. Fang, W. Kaniewski, N-H. Chua, N. Tumer.
Analysis of the mechanism of protection in transgenic plants expressing the potato virus X coat protein or its antisense RNA.
The EMBO J. 7: 1273-1280, 1988.
[53] M. Cuozzo, K.M. O’Connell, W. Kaniewski, R-X. Fang, N-H. Chua, N.E. Tumer*.
Viral protection in transgenic tobacco plants expressing the cucumber mosaic virus coat protein or its antisense RNA.
Biotechnology  6: 549-557, 1988.
[54] R-X. Fang, W. Min Jou, D. Huylebroeck, R.Devos, W. Fiers.
Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin.
Cell  25: 315-323, 1981.
[55] M. Verhoeyen, R-X. Fang, W. Min Jou, R. Devos, D. Huylebroeck, E. Saman, W. Fiers.
Antigenic drift  between the hemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75.
Nature  286: 771-776, 1980.
[56] W. Min Jou, M. Verhoeyen, R. Devos, E. Saman, R-X. Fang, D. Huylebroeck, W. Fiers, G.Threlfall, C. Barber, N. Carey, S. Emtage.
Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75(H3N2) strain as determined from loned cDNA.
Cell  19: 683-696, 1980.
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