Principal Investigator,Professor :

Zhu,Mingzhao Ph.D.
Address:NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China
Telephone/fax:
E-mail:zhumz@im.ac.cn
Research Interests
Dr. Mingzhao Zhu has been devoted to the field of adaptive immunity, especially focusing on lymphoid tissue microenvironment and T cell development and response. More specifically:
1. The role of lymphoid tissue microenvironment in T cell development, homeostasis and response.
2. Epigenetic regulation of T cell development, homeostasis and response.
3. Vaccine immunology. 
Education/degrees
1994.09 – 1998.07   BS. School of Life Sciences, Peking University
1998.09 – 2003.07   PhD. Chinese Academy of Medical Science & Peking Union Medical College
Work experience
2004.01 – 2008.12   Postdoc, Department of Pathology, University of Chicago
2009.01 – 2009.12   Research assistant professor, Department of Pathology, University of Chicago
2009.10 – 2023.11   Principal Investigator, Professor, Institute of Biophysics, Chinese Academy of Sciences
2015.10 – present   Professor, University of Chinese Academy of Sciences
2023.11 – present   Principal Investigator, Professor, Institute of Microbiology, Chinese Academy of Sciences

 

Professional appointments
2021.08 – present   Secretary-General, Infection and Immunity Branch, Chinese Biophysical Society
2022.08 – present   Member of the Standing Committee,Tumor Immunology and Biotherapy Branch, Chinese Society of Immunology
2023.06 – present   Deputy Director, Immune Deficiency Monitoring and Transformation Committee, China Association for the Promotion of Human Health Science and Technology
2019.12 – present   Member of the Immunology Committee, Chinese Pathophysiological Society
2023.01 – present   Member of Editorial Board, Science Bulletin

 

Awards
2020 National Science Fund for Distinguished Young Scholars
2020 Zhu Li Yuehua Outstanding Teacher Award of University of Chinese Academy of Sciences
2021 "Scholar Award" of the WuXi AppTec Life Chemistry Research Award
2021 Top Ten Advances in Chinese Science in 2020
2022 Outstanding Scientific and Technological Achievement Award of Chinese Academy of Sciences
Publication

1.Ren, B., Xia, H., Liao, Y., Zhou, H., Wang, Z., Shi, Y., and Zhu, M.* (2022) Endothelial SIRPα signaling controls thymic progenitor homing for T cell regeneration and antitumor immunity. Elife 11:e69219

2.Zhu, M*. (2021) Immunological perspectives on spatial and temporal vaccine delivery. Advanced Drug Delivery Reviews 178, 113966

3.Duan, H., Jing, L., Jiang, X., Ma, Y., Wang, D., Xiang, J., Chen, X., Wu, Z., Yan, H., Jia, J., Liu, Z., Feng, J., Zhu, M.*, and Yan, X.* (2021) CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice. J Clin Invest 131, 148568

4.Xia, H., Zhong, S., Zhao, Y., Ren, B., Wang, Z., Shi, Y., Chai, Q., Wang, X.*, and Zhu, M.* (2021) Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells. Frontiers in Immunology 12, 707404

5.Wang, W., Huang, B., Zhu, Y., Tan, W.*, and Zhu, M.* (2021) Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice. Cellular & Molecular Immunology 18, 749-751

6.Wang, W., Zhou, X., Bian, Y., Wang, S., Chai, Q., Guo, Z., Wang, Z., Zhu, P., Peng, H., Yan, X., Li, W., Fu, Y.-X., and Zhu, M.* (2020) Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B. Nature Nanotechnology 15, 406-416

7.Long, H., Zhang, L., Lv, M., Wen, Z., Zhang, W., Chen, X., Zhang, P., Li, T., Chang, L., Jin, C., Wu, G., Wang, X., Yang, F., Pei, J., Chen, P., Margueron, R., Deng, H., Zhu, M.*, and Li, G.* (2020) H2A.Z facilitates licensing and activation of early replication origins. Nature 577, 576-581

8.Pian, Y., Chai, Q.*, Ren, B., Wang, Y., Lv, M., Qiu, J., and Zhu, M.* (2020) Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTβR Pathway during Listeria Infection. J Immunol 205, 853-863

9.Wang, Z., Wang, W., Chai, Q., and Zhu, M.* (2019) Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LTβR Signaling. J Immunol 202, 2999-3007

10.Wang, W., Liu, Z., Zhou, X., Guo, Z., Zhang, J., Zhu, P., Yao, S., and Zhu, M.* (2019) Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy. Nanomedicine: nanotechnology, biology, and medicine 16, 69-78

11.Wang, Z., Chai, Q.*, and Zhu, M.* (2018) Differential Roles of LTbetaR in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation. J Immunol 201, 69-76

12.Liu, X., Liu, L., Ren, Z., Yang, K., Xu, H., Luan, Y., Fu, K., Guo, J., Peng, H., Zhu, M.*, and Fu, Y. X.* (2018) Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion. Cell Rep 24, 2101-2111

13.Jin, C., and Zhu, M.* (2018) RelB intrinsically regulates the development and function of medullary thymic epithelial cells. Sci China Life Sci 61, 1039-1048.

14.Jin, L., Guo, X., Shen, C., Hao, X., Sun, P., Li, P., Xu, T., Hu, C., Rose, O., Zhou, H., Yang, M., Qin, C.-F., Guo, J., Peng, H., Zhu, M., Cheng, G., Qi, X., and Lai, R. (2018) Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor. Nature Immunology 19, 342-353

15.Yang, K., Liang, Y., Sun, Z., Xue, D., Xu, H., Zhu, M., Fu, Y. X., and Peng, H. (2018) T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response. J Virol 92, e00428-00418

16.Wu, W., Shi, Y., Xia, H., Chai, Q., Jin, C., Ren, B., and Zhu, M.* (2017) Epithelial LTbetaR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice. Scientific Reports 7, 44481

17.Liu, Z., Zhou, C., Qin, Y., Wang, Z., Wang, L., Wei, X., Zhou, Y., Li, Q., Zhou, H., Wang, W., Fu, Y.-X.*, Zhu, M.*, and Liang, W.* (2017) Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. Cell Discovery 3, 17007

18.Wang, J., Ge, P., Qiang, L., Tian, F., Zhao, D., Chai, Q., Zhu, M., Zhou, R., Meng, G., Iwakura, Y., Gao, G. F., and Liu, C. H. (2017) The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. Nature Communications 8, 244

19.Shi, Y., Wu, W., Chai, Q., Li, Q., Hou, Y., Xia, H., Ren, B., Xu, H., Guo, X., Jin, C., Lv, M., Wang, Z., Fu, Y. X., and Zhu, M.* (2016) LTbetaR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nature Communications 7, 12369

20.Tang, H., Zhu, M., Qiao, J., and Fu, Y. X. (2017) Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy. Cell Mol Immunol 14(10):809-818

21.Liu, Z., Zhou, H., Wang, W., Fu, Y. X., and Zhu, M.* (2016) A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice. Oncoimmunology 5, e1147641

22.Lv, M., Wu, W., Zhang, Y., and Zhu, M.* (2015) Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon. Scientific Reports 5, 12954

23.Liu, Z., Zhou, H., Wang, W., Tan, W., Fu, Y. X., and Zhu, M.* (2014) A novel method for synthetic vaccine construction based on protein assembly. Scientific Reports 4, 7266

24.Shi, Y., and Zhu, M.* (2013) Medullary thymic epithelial cells, the indispensable player in central tolerance. Sci China Life Sci 56, 392-398

25.Hou, Y., Lin, H., Zhu, L., Liu, Z., Hu, F., Shi, J., Yang, T., Shi, X., Zhu, M., Godley, B. F., Wang, Q., Li, Z., and Zhao, Y. (2013) Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression. Arthritis and Rheumatism 65, 2835-2846

26.Zhu, M.*, and Fu, Y.* (2012) Proinflammatory IL-17 induces iBALT development. Cell Mol Immunol 9, 101-102

27.Zhu, M.*, Yang, Y., Wang, Y., Wang, Z., and Fu, Y.-X.* (2011) LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy. J Immunol 186, 7156-7163

28.Zhu, M., and Fu, Y.-X. (2011) The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling. Immunological Reviews 244, 75-84

29.Zhu, M.*, and Fu, Y.-X.* (2011) Deflating the Lymph Node. Immunity 34, 8-10

30.Zhu, M.*, and Fu, Y.* (2010) The complicated role of NF-kappaB in T-cell selection. Cell Mol Immunol 7, 89-93

31.Zhu, M.*, Brown, N. K., and Fu, Y.-X.* (2010) Direct and indirect roles of the LT[beta]R pathway in central tolerance induction. Trends in Immunology 31, 325-331

32.Wang, Y., Zhu, M., Yu, P., and Fu, Y. X. (2010) Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition. J Immunol 184, 1589-1595

33.Zhou, P., Fang, X., McNally, B. A., Yu, P., Zhu, M., Fu, Y. X., Wang, L., Liu, Y., and Zheng, P. (2009) Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition. Proc Natl Acad Sci U S A 106, 17134-17139

34.Wang, Y., Zhu, M., Miller, M., and Fu, Y. X. (2009) Immunoregulation by tumor necrosis factor superfamily member LIGHT. Immunol Rev 229, 232-243

35.Zhu, M., and Fu, Y. X. (2008) Coordinating development of medullary thymic epithelial cells. Immunity 29, 386-388

36.Zhu, M., Chin, R. K., Tumanov, A. V., Liu, X., and Fu, Y. X. (2007) Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla. J Immunol 179, 8069-8075

37.Li, J., Li, Y., Yao, J. Y., Jin, R., Zhu, M. Z., Qian, X. P., Zhang, J., Fu, Y. X., Wu, L., Zhang, Y., and Chen, W. F. (2007) Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice. Proc Natl Acad Sci U S A 104, 18175-18180

38.Zhu, M., Chin, R. K., Christiansen, P. A., Lo, J. C., Liu, X., Ware, C., Siebenlist, U., and Fu, Y. X. (2006) NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clin Invest 116, 2964-2971

39.Chin, R. K., Zhu, M., Christiansen, P. A., Liu, W., Ware, C., Peltonen, L., Zhang, X., Guo, L., Han, S., Zheng, B., and Fu, Y. X. (2006) Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol 177, 290-297

40.Zhu, M., Xu, X., Liu, H., Liu, X., Wang, S., Dong, F., Yang, B., and Song, G. (2003) Enhancement of DNA vaccine potency against herpes simplex virus 1 by co-administration of an interleukin-18 expression plasmid as a genetic adjuvant. J Med Microbiol 52, 223-228