Principal Investigators
State Key Laboratory of Microbial Resources
State Key Laboratory of Mycology
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
CAS Key laboratory of Pathogenic Microbiology & Immunology
The Center for Microbial Resource and Big Data-
CAS Key laboratory of Pathogenic Microbiology & Immunology
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Principal Investigator,Professor : Viral Replication and Cell Cycle Regulation

LIU Ningning
Title：PhD, Professor
Dept.:CAS Key Laboratory of Pathogenic Microbiology and Immunology
Address：NO.1 Beichen West Road, Chaoyang District, Beijing 100101, P. R. China
E-mail：liunn@im.ac.cn or nnliu01@hotmail.com
Research Interests
1. Immune modulation of the tumor microenvironment and cancer immunotherapy;
2. Molecular mechanism of chronic infection to liver cancer;
3. Glucose and lipid metabolism during fatty liver, NAFLD and NASH.
Education/degrees
2011-2014 Ph.D. Institute of Microbiology, University of Chinese Academy of Sciences
2008-2011 M.S. Shandong Agricultural University 
2004-2008 B.S. Shandong Agricultural University 
Work experience
2022.11- Professor, Institute of Microbiology, CAS, China
2021-2022 Instructor, UT Southwestern Medical Center, USA
2017-2021 Postdoctoral Associate, University of Minnesota, USA
2014-2017 Assistant professor, Institute of Microbiology, Chinese Academy of Sciences, China 
The main research areas
Liver specific immune response and lipid metabolic regulation to pathogens. 
Publication(only show first and co-first author)

1. Dandan Qi, Min Lu, Pengfei Xu, Xinli Yao, Yongchen Chen, Lipeng Gan, Yong Li, Yahua Cui, Xiaomei Tong, Shuhong Liu, Jingmin Zhao#, Ningning Liu#, Xin Ye#. Transcription Factor ETV4 Promotesthe Development of Hepatocellular Carcinoma by Driving Hepatic TNF-α Signaling. Cancer Communications, 2023. #co-corresponding author.

2.  Ningning Liu*, Jing Tian*, Clifford J. Steer, Qinghua Han# and Guisheng Song#. MicroRNA-206-3p Suppresses Hepatic Lipogenesis and cholesterol synthesis while driving cholesterol efflux. Hepatology, 2023. *co-first author.

3. Ningning Liu, Clifford J. Steer, and Guisheng Song. MicroRNA-15a/16-1 Prevent Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Regulatory T Cells. Gastroenterology, 2022.

4.  Ningning Liu, Xiaomei Wang, Clifford J. Steer, and Guisheng Song. MicroRNA-206 Promotes the Recruitment of CD8+ T Cells by Driving M1 Phase Polarization of Kupffer Cells. Gut, 2022.

5.  Ningning Liu, Clifford J Steer, Guisheng Song. MicroRNA-206 Enhances Antitumor Immunity by Disrupting the Communication between Malignant Hepatocytes and Tregs in c-Myc Mice. Hepatology, 2022.

6.  Ningning Liu*, Tianpeng Zhang*, Clifford J Steer, Guisheng Song.  MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis. Cell & Bioscience, 2022. *co-first author.

7.  Ningning Liu*, Qi Liu*, Xiaohai Yang*, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, and Xin Ye. Hepatitis B Virus-Upregulated LNC-HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity. Hepatology, 2018. *co-first author.

8.  Ningning Liu*, Jinfang Zhang*, Xiaohai Yang, Tong Jiao, Xin Zhao, Wenxia Li, Jianhua Zhu, Pu Yang, Jianping Jin, Jirun Peng, Zhiwei Li, and Xin Ye. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx to Enhance its Stability and Function. Journal of Virology, 2017. *co-first author.

9.  Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, and Xin Ye. Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7-Transforming Growth Factor Beta Pathway. Journal of Virology, 2015.

10. Ningning Liu, Jinfang Zhang, Tong Jiao, Zhiwei Li, and Xin Ye. Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA-15a/16 Cluster. Journal of Virology, 2013.