Principal Investigators
State Key Laboratory of Microbial Resources
State Key Laboratory of Mycology
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
CAS Key laboratory of Pathogenic Microbiology & Immunology
The Center for Microbial Resource and Big Data-
CAS Key laboratory of Pathogenic Microbiology & Immunology
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Principal Investigator,Professor : Viral Infection and Biological Pharmacy Research Center

Wenjun (Frank) Liu(Deputy Director)
Title：Professor, Deputy Director of CAS Key Laboratory of Pathogenic Microbiology & Immunology
Address：NO.1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Telephone/fax：86-10-64807497
E-mail：liuwj@im.ac.cn
Background
Wenjun Liu received his DVM from Beijing Agricultural University in Beijing and Ph.D from the University of Florida in Gainesville, Florida. He had worked at China Agricultural University (1985-1989) and National Animal Disease Center of USDA (1988-1989), Howard Hughes Medical institute/Oklahoma Medical Research Foundation (1998-2001), and Genzyme Corporation (2001-2004). Now he is a professor and deputy director in CAS Key Laboratory of Pathogenic Microbiology of Immunology, Institute of Microbiology, Chinese Academy of Science. He is also the director of Biosafety Level 3 Laboratory, Institute of Microbiology, Chinese Academy of Science. In his research area, Dr. Liu has published nearly 70 research articles and reviews.
Research Interests
His lab focuses on the molecular biology of viruses, the interactions of viruses with host cells, the pathogenesis of viral diseases, the post-translational modification of viral proteins, and mechanisms of host defense. The research works are designed to increase fundamental knowledge as well as to facilitate the development of new approaches to control of viral infection.
Publication
1. Heqiao Li, Wenxian Yang, Huizi Li, Xiaoyuan Bai, He Zhang, Wenhui Fan, Wenjun Liu*, Lei Sun*. PROTAC targeting cyclophilin A controls virus-induced cytokine storm. iScience. 2023. doi: 10.1016/j.isci.2023.107535.
2. Pengtao Jiao, Wenhui Fan, Xiaoya Ma, Runshan Lin, Yuna Zhao, Yabo Li, He Zhang, Xiaojuan Jia, Yuhai Bi, Xiaoli Feng, Minghua Li, Wenjun Liu, Ke Zhang*, Lei Sun*. SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1. Autophagy. 2023.doi: 10.1080/15548627.2023.2238579.
3. Jie Min#, Yucen Li#, Xinda Li, Mingge Wang, Huizi Li, Yuhai Bi, Ping Xu, Wenjun Liu*, Xin Ye*, Jing Li*. The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins. PLoS Pathogen. 2023. doi: 10.1371/journal.ppat.1011577.
4. Jie Min, Ying Cao, Haizhou Liu, Di Liu, Wenjun Liu*, Jing Li*. RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells. Int J Mol Sci. 2022. doi: 10.3390/ijms23179901.
5. Wenqiang Sun, Lihong He, Huicong Lou, Wenhui Fan, Limin Yang, Gong Cheng, Wenjun Liu*, Lei Sun*. The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs. Front Immunol. 2022. doi: 10.3389/fimmu.2022.898520.
6. Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu*, Lei Sun*. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A. Cell Rep. 2022. doi: 10.1016/j.celrep.2022.110513.
7. Weinan Zheng #, Liang Cui #, Minghui Li #, Yun Li, Wenhui Fan, Limin Yang, Jing Li, Lei Sun*, Wenjun Liu. Nucleoprotein phosphorylation site (Y385) mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature. Sci China Life Sci. 2021. doi: 10.1007/s11427-020-1727-y.
8. Limin Yang*, Deyu Tian, Jian-Bao Han, Wenhui Fan, Yuan Zhang, Yunlong Li, Wenqiang Sun, Yanqiu Wei, Xiaodong Tian, Dan-Dan Yu, Xiao-Li Feng, Gong Cheng, Yuhai Bi, Yong-Tang Zheng*, Wenjun Liu*. A recombinant receptor-binding domain in trimeric form generates protective immunity against SARS-CoV-2 infection in nonhuman primates. Innovation (Camb). 2021. doi: 10.1016/j.xinn.2021.100140.
9. Xiaoyuan Bai, Wenxian Yang, Xiaohan Luan, Huizi Li, Heqiao Li, Deyu Tian, Wenhui Fan, Jing Li, Beinan Wang, Wenjun Liu*, Lei Sun*. Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection. Cell Rep. 2021. doi: 10.1016/j.celrep.2021.109159.
10. Xiaodong Tian, Ling Liu, Wenguo Jiang, He Zhang, Wenjun Liu*, Jing Li*. Potent and Persistent Antibody Response in COVID-19 Recovered Patients. Front Immunol. 2021. doi: 10.3389/fimmu.2021.659041.
11. Wenqiang Sun, Lihong He, He Zhang, Xiaodong Tian, Zhihua Bai, Lei Sun, Limin Yang, Xiaojuan Jia, Yuhai Bi, Tingrong Luo, Gong Cheng, Wenhui Fan*, Wenjun Liu*, Jing Li*. Signal Transduct Target Ther. 2021. doi: 10.1038/s41392-021-00750-w.
12. Jing Li*, Wenjun Liu*. Puzzle of highly pathogenic human coronaviruses (2019-nCoV). Protein Cell. 2020. doi: 10.1007/s13238-020-00693-y.
13. Jing Li, Kun Zhang, Wenhui Fan, Shuang Zhang, Yun Li, Jinyan Gu, Jiyong Zhou*, Wenjun Liu*. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. Front Microbiol. 2019. doi: 10.3389/fmicb.2019.02344.
14. Liang Cui, Weinan Zheng, Minghui Li, Xiaoyuan Bai, Wenxian Yang, Jing Li, Wenhui Fan, George Fu Gao, Lei Sun*, Wenjun Liu. Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein. Front Microbiol. 2019. doi: 10.3389/fmicb.2019.01816.
15. Weinan Zheng, Wenhui Fan, Shuang Zhang, Pengtao Jiao, Yingli Shang, Liang Cui, Madina Mahesutihan, Jing Li, Dayan Wang, George Fu Gao, Lei Sun*, Wenjun Liu. Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export. Cell Rep. 2019. doi: 10.1016/j.celrep.2019.04.053.
16. Lirong Liu, Wenhui Fan, He Zhang, Shuang Zhang, Liang Cui, Meng Wang, Xiaoyuan Bai, Wenxian Yang, Lei Sun, Limin Yang, Wenjun Liu*, Jing Li*. Interferon as a Mucosal Adjuvant for an Influenza Vaccine in Pigs. Virol Sin. 2019. doi: 10.1007/s12250-019-00102-7.
17. Can Chen, Wenhui Fan, Jing Li, Weinan Zheng, Shuang Zhang, Limin Yang, Di Liu, Wenjun Liu*, Lei Sun*. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. Front. Cell. Infect. Microbiol. 2018. doi: 10.3389/fcimb.2018.00127.
18. Yeping Sun, Jingwen Jiang, Po Tien, Wenjun Liu *, Jing Li*. IFN-λ: A new spotlight in innate immunity against influenza virus infection. Protein & Cell. 2018. doi: 10.1007/s13238-017-0503-6.
19. Wei Liu#, Jing Li#, Weinan Zheng, Yingli Shang, Zhendong Zhao, Shanshan Wang, Yuhai Bi, Shuang Zhang, Chongfeng Xu, Ziyuan Duan, Lianfeng Zhang, Yue L Wang, Zhengfan Jiang, Wenjun Liu*, Lei Sun*. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife. 2017. doi: 10.7554/eLife.24425.
20. Jing Li#, Weinan Zheng#, Lidan Hou#, Can Chen, Wenhui Fan, Hongren Qu, Jingwen Jiang, Jinhua Liu, George Fu Gao, Jiyong Zhou, Lei Sun*, W-J Liu*. Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism. Cellular Microbiology. 2016. doi: 10.1111/cmi.12692.
21. Weinan Zheng#, Shuaishuai Cao#, Can Chen#, Jing Li, Shuang Zhang, Jingwen Jiang, Yange Niu, Wenhui Fan, Yun Li, Yuhai Bi, George Fu Gao, Lei Sun*, Wenjun Liu*. Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I. Cellular Microbiology. 2016. doi: 10.1111/cmi.12643.
22. Jingwen Jiang, Jing Li*, Wenhui Fan, Weinan Zheng, Meng Yu, Can Chen, Lei Sun, Yuahi Bi, Chan Ding, George Fu Gao, Wenjun Liu*. Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. Journal of Virology. 2016. doi: 10.1128/JVI.00549-16.
23. Weinan Zheng, Jing Li, Shanshan Wang, Shuai Cao, Jingwen Jiang, Can Chen, Chan Ding, Chuan Qin, Xin Ye, George Fu Gao, Wenjun Liu*. Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein. Journal of Virology. 2015. doi: 10.1128/JVI.00015-15.
24. Yuhai Bi, Qing Xie, Shuang Zhang, Yun Li, Haixia Xiao, Tao Jing, Weinan Zheng, Jing Li, Xiaojuan Jia, Lei Sun, Jinhua Liu, Chuan Qin, George F Gao, Wenjun Liu*. Assessment of the internal genes of influenza A (H7N9) virus contributing to the high pathogenicity in mice. Journal of Virology. 2014. doi: 10.1128/JVI.02390-14.
25. Shuai Cao#, Jingwen Jiang#, Jing Li, Yun Li, Limin Yang, Shanshan Wang, Jinghua Yan, George F Gao, Wenjun Liu*. Characterization of The Nucleocytoplasmic Shuttle of The Matrix Protein of Influenza B Virus. Journal of Virology. 2014. doi: 10.1128/JVI.00794-14.
26. Shengyan Gao, Shanshan Wang, Shuai Cao, Lei Sun, Jing Li, Yuhai Bi, George F Gao, Wenjun Liu*. The characteristics of nucleocytoplasmic transport of H1N1 influenza A viruses nuclear export protein (NEP). Journal of Virology. 2014. doi: 10.1128/JVI.00257-14.
27. Shanshan Wang, Zhendong Zhao, Yuhai Bi, Lei Sun, Xiaoling Liu*, W-J Liu*. Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling its nuclear import. Journal of Virology, 2013. doi: 10.1128/JVI.03024-12.
28. Caiwei Chen, Jing Li, Yuahi Bi, Limin Yang, Shanshan Meng, Yuancheng Zhou, Xiaojuan Jia, Songdong Meng, Lei Sun, Wenjun Liu*. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity. Vaccine. 2013. doi: 10.1016/j.vaccine.2013.01.049.
29. Shuai Cao, Yi Shi, Shuguang Tan, Hao Song, George F. Gao*, Wenjun Liu*. Reply to "Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1"--Sequence Sharing Between Viral Nuclear Export Signals (NES) and CD8+ T Cell Epitopes. Journal of Virology. 2012. doi: 10.1128/JVI.06586-11.
30. Maorong Yu, Xiaoling Liu, Shuai Cao, Zhendong Zhao, Ke Zhang, Qing Xie, Caiwei Chen, Shengyan Gao, Yuhai Bi, Lei Sun, Xin Ye, George F. Gao, Wenjun Liu*. Identification and Characterization of three novel nuclear export signals in influenza A virus nucleoprotein. Journal of Virology. 2012. doi: 10.1128/JVI.06159-11.
31. Shui Cao, Xiaoling Liu, Maorong Yu, Jing Li, Xiaojuan Jia, Yuhai Bi, Lei Sun, George F. Gao, Wenjun Liu*. A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for the Efficient Virus Replication. Journal of Virology. 2012. doi: 10.1128/JVI.06586-11.