WANG Shuo----微生物研究所

CAS Key laboratory of Pathogenic Microbiology & Immunology

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Principal Investigator,Professor : Research Group of Mucosal Immunity and Disease Regulation

WANG Shuo

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：010-64806162

E-mail：wangshuo@im.ac.cn

Research area

Mucosal immunity and regulation of mucosal diseases, focusing on: The interaction between intestinal microbiota and intestinal lymphocytes under physiological and pathological conditions; The anti infection mechanism of respiratory mucosal immune system induced by respiratory pathogen infection.

Research content and significance

1.The regulatory mechanism of the interaction between gut microbiota and intestinal lymphocytes under physiological and pathological conditions. Study the relationship between gut microbiota and the establishment and functional regulation of the intestinal mucosal immune system during the occurrence and development of enteritis and colorectal cancer, and explore immune intervention strategies based on symbiotic bacterial regulation.
2. Anti-infection response of the respiratory mucosal immune system. To reveal the anti-infection immune response in the lung tissues, identify mucosal immune cell subsets by multi-omics methods, and study the dynamic regulation of respiratory immune system, so as to provide a theoretical basis for respiratory vaccine design and drug development.

Main learning and work experience

- Education experience
2002.9-2006.7 Zhejiang University Bioengineering BS
2006.9-2012.6 Institute of Biophysics Chinese Academy of Sciences Biochemistry and Molecular Biology PhD

- work experience
2012.7–2013.11    Institute of Biophysics of CAS   Assistant Professor
2013.12–2015.12     Institute of Biophysics of CAS   Associate professor
2015.12-2019.1     Institute of Biophysics of CAS    Professor
2019.1-up to now    Institute of Microbiology of CAS Professor
- Awards
In 2024, Received the Beijing Outstanding Youth Science Fund
In 2022, The second prize of Beijing Natural Science Award
In 2019, Outstanding Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences
In 2018, Beijing Science and Technology Progress Award
In 2017, r National Natural Science Foundation for Outstanding Young Scholars
In 2015, Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences

Research team

working personnel
Min Zhao PhD Assistant Professor（2019-）
Hiring personnel
Qingjie Kong MS Research Assistant（2021-）
Undergraduate student
Fei Shao Doctoral students （2019-）
Xusheng Zhang Doctoral students （2020-）
Jiangwen Ma Master's degree students（2020-）
Zhen Liu Doctoral students （2021-）
Xintong Gao Master's degree students（2021-）
Dou Yu Doctoral students （2022-）
Zhuozhou Tang Master's degree students（2022-）

Publication

Representative papers in the past five years:

1．Zhang X ^#, Yu D ^#, Wu D^#, Gao X, Shao F, Zhao M, Wang J, Ma J, Wang W, Qin X, Chen Y^*, Xia P^*, Wang S^*. Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance. Cell Host & Microbe. 2023.31(3):418-432.e8.

2．Zhu F^#, Ma J^#, Li W^#, Liu Q^#, Qin X, Qian Y, Wang C, Zhang Y, Li Y, Jiang D, Wang S^*, Xia P^*. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023. 56, 753–767.

3．Zhao M^#, Shao F^#, Yu D^#, Zhang J, Liu Z, Ma J, Xia P^*, Wang S^*. Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nature Communications. 2022. 13(1):7600.

4．Shao F, Yu D, Xia P, Wang S^*. Dynamic regulation of innate lymphoid cells in the mucosal immune system. Cellular & Molecular Immunology. 2021. 18(6):1387-1394.

5．Zhu F^#, Yu D^#, Qin X^#, Qian Y^#, Ma J, Li W, Liu Q, Wang C, Zhang Y, Li Y, Jiang D, Wang S^*, Xia P^*. The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection. Cellular & Molecular Immunology. 2023. 20(3):264-276.

6．Ma J^#, Zhu F^#, Zhao M^#, Shao F, Yu D, Ma J, Zhang X, Li W, Qian Y, Zhang Y, Jiang D, Wang S^*, Xia P^*. SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. EMBO Journal. 2021. 40(18):e108249.

Other representative papers:

1. Wang S^*, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z^*. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell. 2017. 171(1). 201-216. （^*co-corresponding author）

2. Wang S^#*, Qu Y^#, Xia P^#, Chen Y^#, Zhu X, Zhang J, Wang G, Tian Y^#, Ying J^*, Fan Z^*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Research. 2020. 30(7):610–622. （^*co-corresponding author）

3. Xia P, Wang S^*, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z^*. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018. 48: 688-701 e687. （^*co-corresponding author）

4. Xia P^#, Wang S^#, Xiong Z^#, Zhu X^#, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y^*, Fan Z^*. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nature Immunology. 2018. 19(2):141-150.

5. Wang S^#, Xia P^#, Chen Y^#, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan, Z^*. Natural killer-like B cells prime innate lymphocytes against microbial infection. Immunity. 2016. 45(1):131-144.

6. Wang S, Xia P, Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nature Communications. 2016. 7.11023.

7. Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z. Transient activation of autophagy via Sox2-Mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013.13(5).617–625.

Participating in the compilation of monographs

1.《Immunological Progress》 People's Health Publishing House,2016