WANG Shuo----微生物研究所

CAS Key laboratory of Pathogenic Microbiology & Immunology

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Principal Investigator,Professor : Research Group of Mucosal Immunity and Disease Regulation

WANG Shuo

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：010-64806984

E-mail：wangshuo@im.ac.cn

Research area

Mucosal immunity and regulation of mucosal diseases, focusing on: The interaction between intestinal microbiota and intestinal lymphocytes under physiological and pathological conditions; The anti infection mechanism of respiratory mucosal immune system induced by respiratory pathogen infection.

Research content and significance

1.The regulatory mechanism of the interaction between gut microbiota and intestinal lymphocytes under physiological and pathological conditions. Study the relationship between gut microbiota and the establishment and functional regulation of the intestinal mucosal immune system during the occurrence and development of enteritis and colorectal cancer, and explore immune intervention strategies based on symbiotic bacterial regulation.
2. Anti-infection response of the respiratory mucosal immune system. To reveal the anti-infection immune response in the lung tissues, identify mucosal immune cell subsets by multi-omics methods, and study the dynamic regulation of respiratory immune system, so as to provide a theoretical basis for respiratory vaccine design and drug development.

Research team leader

Research project leader: Shuo Wang
Tel: 010-64806984
E-mail：wangshuo@im.ac.cn
Address: No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing
Postal code: 100101

Main learning and work experience

- Education experience
2002.9-2006.7 Zhejiang University Bioengineering BS
2006.9-2012.6 Institute of Biophysics Chinese Academy of Sciences Biochemistry and Molecular Biology PhD

- work experience
2012.7–2013.11    Institute of Biophysics of CAS   Assistant Professor
2013.12–2015.12     Institute of Biophysics of CAS   Associate professor
2015.12-2019.1     Institute of Biophysics of CAS    Professor
2019.1-up to now    Institute of Microbiology of CAS Professor
- Awards
In 2024, Beijing Outstanding Youth Science Fund
In 2022, The second prize of Beijing Natural Science Award
In 2019, Outstanding Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences
In 2018, The first prize of Beijing Science and Technology Progress Award

In 2017, National Natural Science Foundation for Outstanding Young Scholars

In 2015, Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences

Research team

working personnel
Min Zhao PhD Associate Professor
Fei Shao Postdoctor
Hiring personnel
Qingjie Kong MS Research Assistant
Undergraduate student
Zhen Liu Doctoral students （2021-）
Dou Yu Doctoral students （2022-）
Zhuozhou Tang Master's degree students（2022-）
Aoyi Liu Master's degree students（2023-）
Yude Guan Doctoral students （2024-）
Jiaqi Li Master's degree students（2024-）
Letong Yang Master's degree students（2024-）

Representative Papers

Representative papers in the past five years:

1. Zhang X ^#, Yu D ^#, Wu D^#, Gao X, Shao F, Zhao M, Wang J, Ma J, Wang W, Qin X, Chen Y^*, Xia P^*, Wang S^*. Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance. Cell Host & Microbe. 2023.31(3):418-432.e8.

2. Zhu F^#, Ma J^#, Li W^#, Liu Q^#, Qin X, Qian Y, Wang C, Zhang Y, Li Y, Jiang D, Wang S^*, Xia P^*. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023. 56, 753–767.

3. Shao F^#, Liu Z^#, Wei Q^#, Yu D, Zhao M, Zhang X, Gao X, Fan Z, Wang S^*. FOXO1 orchestrates the intestinal homeostasis via a neuronal signaling in group 3 innate lymphoid cells. Journal of Experimental Medicine. 2023. 220(10):e20230133.

4. Zhang X, Gao X, Liu Z, Shao F, Yu D, Zhao M, Qin X, Wang S^*. Microbiota regulates the TET1-mediated DNA hydroxymethylation program in murine innate lymphoid cell differentiation. Nature Communications. 2024. 15(1):4792.

5. Zhao M^#, Shao F^#, Yu D^#, Zhang J, Liu Z, Ma J, Xia P^*, Wang S^*. Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nature Communications. 2022. 13(1):7600.

6. Zhu F^#, Yu D^#, Qin X^#, Qian Y^#, Ma J, Li W, Liu Q, Wang C, Zhang Y, Li Y, Jiang D, Wang S^*, Xia P^*. The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection. Cellular & Molecular Immunology. 2023. 20(3):264-276.

7. Shao F, Yu D, Xia P, Wang S^*. Dynamic regulation of innate lymphoid cells in the mucosal immune system. Cellular & Molecular Immunology. 2021. 18(6):1387-1394.

8. Ma J^#, Zhu F^#, Zhao M^#, Shao F, Yu D, Ma J, Zhang X, Li W, Qian Y, Zhang Y, Jiang D, Wang S^*, Xia P^*. SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. EMBO Journal. 2021. 40(18):e108249.

Other representative papers:

1. Wang S^*, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z^*. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell. 2017. 171(1). 201-216. （^*co-corresponding author）

2. Wang S^#*, Qu Y^#, Xia P^#, Chen Y^#, Zhu X, Zhang J, Wang G, Tian Y^#, Ying J^*, Fan Z^*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Research. 2020. 30(7):610–622. （^*co-corresponding author）

3. Xia P, Wang S^*, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z^*. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018. 48: 688-701 e687. （^*co-corresponding author）

4. Xia P^#, Wang S^#, Xiong Z^#, Zhu X^#, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y^*, Fan Z^*. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nature Immunology. 2018. 19(2):141-150.

5. Wang S^#, Xia P^#, Chen Y^#, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan, Z^*. Natural killer-like B cells prime innate lymphocytes against microbial infection. Immunity. 2016. 45(1):131-144.

6. Wang S, Xia P, Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nature Communications. 2016. 7.11023.

7. Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z. Transient activation of autophagy via Sox2-Mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013.13(5).617–625.

Participating in the compilation of monographs

1.《Immunological Progress》 People's Health Publishing House,2016