WANG Shuo----微生物研究所

CAS Key laboratory of Pathogenic Microbiology & Immunology

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Principal Investigator,Professor : Research Group of Mucosal Immunity and Disease Regulation

WANG Shuo

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：010-64806162

E-mail：wangshuo@im.ac.cn

Research area

The regulation of intestinal mucosal lymphocytes during the process of inflammation cancer transition and pathogen infection, the interaction between intestinal microbiota and intestinal lymphocytes under physiological and pathological conditions, and the anti-infection responses of the respiratory mucosal immune system.

Research content and significance

1.The regulation of intestinal mucosal lymphocytes during the process of inflammation cancer transition and pathogen infection. Analyze the types of infiltrating innate lymphocytes in colon cancer tumors, screen for molecular markers expressed by innate immune lymphocytes that are closely related to the progression of colon cancer, and further explore clinical targets.
2.Study the interaction between gut microbiota and intestinal lymphocytes under physiological and pathological conditions. Study the roles of gut microbiota in the establishment and regulation of the mucosal immune system.
3.The anti-infection responses of the respiratory mucosal immune system. Systematically revealing the anti-infection immune response of in the lung tissue, identifying mucosal immune cell subpopulations via multiple omics methods, studying the immune response patterns of respiratory mucosa, and providing a theoretical basis for vaccine design and drug development.

Main learning and work experience

- Education experience
2002.9-2006.7 College of Materials and chemical engineering Zhejiang University Bioengineering BS
2006.9-2012.6 Institute of Biophysics Chinese Academy of Sciences Biochemistry and Molecular Biology PhD

- work experience
2012.7–2013.11    Institute of Biophysics of CAS   Assistant Professor
2013.12–2015.12     Institute of Biophysics of CAS   Associate professor
2015.12-2019.1     Institute of Biophysics of CAS    Professor
2019.1-up to now    Institute of Microbiology of CAS Professor
- Awards
In 2022, The second prize of Beijing Natural Science Award
In 2019, Outstanding Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences
In 2018, Beijing Science and Technology Progress Award
In 2017, r National Natural Science Foundation for Outstanding Young Scholars
In 2015, Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences

Research team

working personnel
Min Zhao PhD Assistant Professor（2019-）
Hiring personnel
Qingjie Kong MS Research Assistant（2021-）
Undergraduate student
Fei Shao Doctoral students （2019-）
Xusheng Zhang Doctoral students （2020-）
Jiangwen Ma Master's degree students（2020-）
Zhen Liu Doctoral students （2021-）
Xintong Gao Master's degree students（2021-）
Dou Yu Doctoral students （2022-）
Zhuozhou Tang Master's degree students（2022-）

Publication

Representative papers in the past five years:

1．Zhang X ^#, Yu D ^#, Wu D^#, Gao X, Shao F, Zhao M, Wang J, Ma J, Wang W, Qin X, Chen Y^*, Xia P^*, Wang S^*. Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance. Cell Host & Microbe. 2023.31(3):418-432.e8.

2．Zhu F^#, Ma J^#, Li W^#, Liu Q^#, Qin X, Qian Y, Wang C, Zhang Y, Li Y, Jiang D, Wang S^*, Xia P^*. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023. 56, 753–767.

3．Zhao M^#, Shao F^#, Yu D^#, Zhang J, Liu Z, Ma J, Xia P^*, Wang S^*. Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nature Communications. 2022. 13(1):7600.

4．Shao F, Yu D, Xia P, Wang S^*. Dynamic regulation of innate lymphoid cells in the mucosal immune system. Cellular & Molecular Immunology. 2021. 18(6):1387-1394.

5．Zhu F^#, Yu D^#, Qin X^#, Qian Y^#, Ma J, Li W, Liu Q, Wang C, Zhang Y, Li Y, Jiang D, Wang S^*, Xia P^*. The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection. Cellular & Molecular Immunology. 2023. 20(3):264-276.

6．Ma J^#, Zhu F^#, Zhao M^#, Shao F, Yu D, Ma J, Zhang X, Li W, Qian Y, Zhang Y, Jiang D, Wang S^*, Xia P^*. SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. EMBO Journal. 2021. 40(18):e108249.

Other representative papers:

1. Wang S^*, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z^*. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell. 2017. 171(1). 201-216. （^*co-corresponding author）

2. Wang S^#*, Qu Y^#, Xia P^#, Chen Y^#, Zhu X, Zhang J, Wang G, Tian Y^#, Ying J^*, Fan Z^*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Research. 2020. 30(7):610–622. （^*co-corresponding author）

3. Xia P, Wang S^*, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z^*. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018. 48: 688-701 e687. （^*co-corresponding author）

4. Xia P^#, Wang S^#, Xiong Z^#, Zhu X^#, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y^*, Fan Z^*. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nature Immunology. 2018. 19(2):141-150.

5. Wang S^#, Xia P^#, Chen Y^#, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan, Z^*. Natural killer-like B cells prime innate lymphocytes against microbial infection. Immunity. 2016. 45(1):131-144.

6. Wang S, Xia P, Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nature Communications. 2016. 7.11023.

7. Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z. Transient activation of autophagy via Sox2-Mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013.13(5).617–625.

Participating in the compilation of monographs

1.《Immunological Progress》 People's Health Publishing House,2016