Surveillance and early warning, genetic evolution, cross-species transmission and pathogenic mechanisms, and comprehensive biosafety control strategies of Influenza virus, coronavirus and other emerging viral diseases.

Active early warning research of viruses: explore mutated or new influenza viruses or other emerging viruses, study their gene evolution and origins, epidemic distribution, host range, pathogenicity and transmission ability, and combined with human environment and other factors to warn the risk of virus epidemic and outbreak. Pathogenesis and transmission mechanism of viruses: establish cellular and animal infection models to study the molecular basis of the altered host specificity, pathogenicity and transmission ability of viruses, such as variant or new influenza viruses. Comprehensive biosafety control strategies: updating or establishing detection methods based on the discovery of variant or new viruses; designing vaccine and drug targets based on the establishment of infection model and the clarification of pathogenic mechanism; and developing comprehensive biosafety control strategies based on the pathogenic characteristics of virus infection and existing prevention and control methods.

It provides theoretical basis and technical support for high-energy early warning of new virus epidemic and outbreak, elucidation of pathogenic and transmission mechanism, and formulation of comprehensive biosafety prevention and control strategies.

Duan Xuefeng Associate Professor
Yang Jing Assistant Professor
Li Pan Financial Assistant
Li Jiaming Postdoc
Sun Ju Postdoc

2021.04-Present: Director, Biosafety and Animal Experiment Platform (former biosafety level III Laboratory), Institute of Microbiology, Chinese Academy of Sciences;
2019.07-Present: Professor, Institute of Microbiology, Chinese Academy of Sciences;
2018.07-Present: Deputy Director of Influenza Research and Early Warning Center, Chinese Academy of Sciences;
2013.06-Present: Influenza Technology Platform Leader, Institute of Microbiology, Chinese Academy of Sciences;
2017.09-2021.04: Deputy Director of biosafety Level III Laboratory, Institute of Microbiology, Chinese Academy of Sciences;
2015.09-2019.06: Associate Professor, Institute of Microbiology, Chinese Academy of Sciences;
2010.07-2015.08: Assistant Professor, Institute of Microbiology, Chinese Academy of Sciences.

1. 2023, Highly Cited Researcher ;
2. 2023, World top 2% scientists;
3. 2023, Academic Innovation Award of Animal and Poultry Disease Research of China Animal Husbandry and Veterinary Society;
4. 2022, Young Scientist Award of China Experimental Zoology;
5. 2020, Innovation Breakthrough Award of Zhongyuan Union Life Medicine;
6. 2019, the second prize of Natural Science Award of Shandong Province for the research on the Transmission and Evolution of New and Reemerging Avian Influenza Virus in China;
7. 2019, Nominated for the 2019 APEC Science Prize for Innovation, Research and Education (ASPIRE Prize);
8. 2017, First Prize of Science and Technology Award of Chinese Preventive Medicine Association.

1. 2023, Chinese Academy of Sciences Support Youth Team Project in basic research;
2. 2022, selected acute respiratory infections and emerging respiratory infectious diseases innovative integrated Chinese and Western medicine team;
3. 2021, outstanding member of the Chinese Academy of Sciences Youth Innovation Promotion Association;
4. 2018, National Natural Science Foundation of China (NSFC) “Outstanding Young Scholars”;
5. 2017, Member of Youth Innovation Promotion Association of CAS.

1. Post Professor, University of Chinese Academy of Sciences;
2. Experts of the Secretary-General of the United Nations Using Biological Weapons (United Nations Secretary-General's Mechanism, UNSGM);
3. Member of Chinese Preventive Medical Association, Biological Resources Management and Utilization Research Branch;
4. Member of Molecular Diagnotics Branch of China Association for International Medical Exchange (Medical Promotion Association);
5. Member of the National Innovation Alliance for Wildlife Disease Surveillance;
6. Director of China Animal Husbandry and Veterinary Society, Director of Poultry Diseases Branch, standing Director of Society of Animal Infectious Diseases and Veterinary Public Health Branch, Chairman of Youth Professional Group of Society of Animal Infectious Diseases;
7. Beijing Society of Experimental Zoology, professional committee member of Biosafety, lifetime member;
8. Member of Medical Virology Branch, Beijing Medical Association;
9. Editorial Board of Chinese Journal of Experimental and Clinical Virology;
10. Standing Committee member of China Medical Education Association;
11. Chinese Society of Integrated Traditional Chinese and Western Medicine, Infectious Diseases Professional Committee, youth committee member
12. Deputy Chairman of the Asia Pacific Health Emergency Professional Committee of the International Association for Emergency Management Association
13. Young editorial board of hLife Academic Journal;
14. Zoological Research Editorial Board of the Academic Journal (Editor board member).

1. Influenza A and B influenza viruses and Novel coronavirus triple (with internal reference) identification test kit (fluorescent PCR), approved for market application (National Equipment Note: 20233401121).

# First author, * corresponding author;Impact Factor in 2022.
1. Jing Yang, Yuhuan Gong, Chunge Zhang, Ju Sun, Gary Wong, Weifeng Shi, Wenjun Liu, George F.Gao and Yuhai Bi*. Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges. The Innovation (Innovation (Camb)). 2022 Aug 17;3(5):100306. doi: 10.1016/j.xinn.2022.100306.
2. Yuhai Bi#*, Juan Li#, Shanqin Li#, Guanghua Fu#, Tao Jin#, Cheng Zhang, Yongchun Yang, Zhenghai Ma, Wenxia Tian, Jida Li, Shuqi Xiao, Liqiang Li, Renfu Yin, Yi Zhang, Lixin Wang, Yantao Qin, Zhongzi Yao, Fanyu Meng, Dongfang Hu, Delong Li, Gary Wong, Fei Liu,Na Lv, Liang Wang, Lifeng Fu, Yang Yang, Yun Peng, Jinmin Ma, Kirill Sharshov, Alexander Shestopalov, Marina Gulyaeva, George F.Gao, Jianjun Chen, Yi Shi, William J.Liu, Dong Chu, Yu Huang, Yingxia Liu, Lei Liu, Wenjun Liu, Quanjiao Chen*, Weifeng Shi*. Dominant subtype switch in avian influenza viruses during 2016–2019 in China. Nature Communications (NAT COMMUN). 2020 Nov 20;11(1): 5909. doi: 10.1038/s41467-020-19671-3. (IF 2022=16.6, Top 7.5%).
3. Liang Wang, Xavier Didelot, Jing Yang, Gary Wong, Yi Shi, Wenjun Liu, George F.Gao & Yuhai Bi*. Inference of person-to-person transmission of COVID-19 reveals hidden super-spreading events during the early outbreak phase. Nature Communications (NAT COMMUN). 2020, Published: 2020 Oct 6;11(1):5006. doi : 10.1038/s41467-020-18836-4. (IF 2022=16.6, Top 7.5%).
4. Jing Yang#,Chunge Zhang#, Yue Yuan#, Ju Sun#, Lu Lu#, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F.Gao, Paul Digard, Samantha Lycett, Yuhai Bi*. Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China. Emerging Infectious Diseases (EMERG INFECT DIS). 2023 Jun;29(6):1244-1249. doi: 10.3201/eid2906.221723. （IF 2022=11.8, Top 9.6%).
5. Yuhai Bi#, Shuguang Tan#, Yang Yang#, Gary Wong#, Min Zhao, Qingchao Zhang, Qiang Wang, Xiaonan Zhao, Liqiang Li, Jing Yuan, Hao Li, Hong Li, Wen Xu, Weifeng Shi, Chuansong Quan, Rongrong Zou, Jianming Li, Haixia Zheng, Liuqing Yang, William J Liu, Di Liu, Huijun Wang, Yantao Qin, Lei Liu, Chengyu Jiang, Wenjun Liu, Lin Lu, George F Gao*, Yingxia Liu*. Clinical and immunological characteristics of human infections with H5N6 avian influenza virus. Clinical Infectious Diseases (CLIN INFECT DIS). 2019 Mar 19;68(7):1100-1109. doi : 10.1093/cid/ciy681. （IF 2022=11.8, Top 9.6%).
6. Yuhai Bi, Juan Li, Weifeng Shi*.The time is now: a call to contain H9N2 avian influenza viruses. The Lancet Microbe (LANCET MICROBE). 2022 Sep 14; 3(11); e804-e805. doi: 10.1016/S2666-5247(22)00232-4. (IF 2022=38.2, Top 1.1%).
7. Jing Yang#, Jianhua Yan#, Cheng Zhang#, Shanqin Li, Manhua Yuan, Chunge Zhang, Chenguang Shen, Yang Yang, Lifeng Fu, Guanlong Xu, Weifeng Shi , Zhenghai Ma, Ting Rong Luo* and Yuhai Bi*. Genetic, biological and epidemiological study on a cluster of H9N2 avian influenza virus infections among chickens, a pet cat, and humans at a backyard farm in Guangxi, China. Emerging Microbes & Infections (EMERG MICROBES INFEC). 2023 Dec 18;12(1):2143282. doi: 10.1080/22221751.2022.2143282. (IF 2022=13.2, Top 6.3%).
8. Zhongyun Zhang#, Ning Zhang#, Xuancheng Lu#, Min Zhou, Xiaoxiang Yan, Weiqiong Gu, Jingru Yang, Qin Zhang, Cheng Zhang, Yuhuan Gong, Mingjun Jia, Xiaoyu Zhang, Peng Ning, Mei Liu, Xiaoyan Li, Xiaomeng Shi, Wenjun Liu, George F.Gao, Guang Ning, Jiqiu Wang*, Yuhai Bi*. Anti-infection effect of heparin on SARS-CoV-2 in diabetic mouse model. Zoological Research (ZOOL RES). Received: 02 July 2023; Accepted: 04 September 2023; Online: 05 September 2023.44(6):1003-1014. doi: 10.24272/j.issn.2095-8137.2023.108. (IF 2022=4.9, Top 0.9%).
9. Jing Yang#, Min Han#, Liang Wang, Likui Wang, Tianrui Xu, Linhuan Wu, Juncai Ma, Gary Wong, Wenjun Liu, George F.Gao, Yuhai Bi*. Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary. Biosafety and Health (B H). 2022 Aug;4(4):228-233. doi: 10.1016/j.bsheal.2022.07.001.
10. Juan Li#, Chunge Zhang#, Jian Cao#, Yongchun Yang, Hui Dong, Yanan Cui, Xue Yao, Hong Zhou, Lu Lu, Samantha Lycett, Xiaodu Wang, Houhui Song, Wenjun Liu, George F.Gao, Weifeng Shi*, Yuhai Bi*. Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China. Emerging Microbes & Infections (EMERG MICROBES INFEC). 2021 Dec;10(1):1819-1823. doi: 10.1080/22221751.2021.1968317. Received 13 Feb 2021, Accepted 08 Aug 2021, Accepted author version posted online: 16 Aug 2021, Published online:14 Sep 2021.（IF 2022=13.2, Top 7.8%）.
11. Hong Zhou#, Jingkai Ji#, Xing Chen#, Yuhai Bi#, Juan Li, Qihui Wang, Tao Hu, Hao Song, Runchu Zhao, Yanhua Chen, Mingxue Cui, Yanyan Zhang, Alice C.Hughes*, Edward C.Holmes*, and Weifeng Shi*. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. Cell (CELL). 2021 Aug 19;184(17):4380-4391. e14. doi: 10.1016/j.cell.2021.06.008. Epub 2021 Jun 9. (IF 2022=64.5, Top 0.5%).
12. Ting Wang#, Ning Zhang#, Shipan Fan#, Lianzheng Zhao#, Wanlu Song#, Yuhuan Gong, Quan Shen, Cheng Zhang, Peng Ren, Chutong Lin, Wei Fu, George F Gao, Shaohua Ma, Yuhai Bi*, Ye-Guang Chen*. Establishment of human distal lung organoids for SARS-CoV-2 infection. Cell Discovery (CELL DISCOV). 2021 Nov 9;7(1):108. doi: 10.1038/s41421-021-00346-2. 7:108. (IF 2022=33.5, Top 3.4%).
13. Tingting Li#, Hongmin Cai#, Hebang Yao#, Bingjie Zhou#, Ning Zhang#, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A J Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S Richard, Hervé Raoul, Jiaming Lan, Markus A Seeger, Yao Cong, Barry Rockx, Gary Wong*, Yuhai Bi*, Dimitri Lavillette*, Dianfan Li*. A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection. Nature Communications (NAT COMMUN). 2021 Jul 30;12(1):4635. doi: 10.1038/s41467-021-24905-z. (IF 2022=16.6, Top 7.5%).
14. Hong Zhou#, Xing Chen#, Tao Hu#, Juan Li#, Hao Song, Yanran Liu, Peihan Wang, Di Liu, Jing Yang, Edward C Holmes, Alice C Hughes*, Yuhai Bi*, Weifeng Shi*. A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein. Current Biology (CURR BIOL). 2020 Jun 8;30(11):2196-2203. 2020 May 11; S0960-9822(20)30662-X.doi: 10.1016/j.cub.2020.05.023. Online ahead of print. (IF 2022=9.2, Top 10.7%).
15. Yang Yang#, Shanqin Li#, Gary Wong#, Sufang Ma, Zhixiang Xu, Xiaonan Zhao, Hong Li, Wen Xu, Haixia Zheng, Jingyan Lin, Qi Zhao, Wenjun Liu, Yingxia Liu, George F.Gao, and Yuhai Bi*. Development of a quadruple qRT-PCR assay for simultaneous identification of highly and low pathogenic H7N9 avian influenza viruses and characterization against oseltamivir resistance. BMC Infectious Diseases (BMC INFECT DIS). 2018 Aug 15;18(1):406. doi: 10.1186/s12879-018-3302-7. （IF 2022=3.7, Top 52.6%).