Surveillance and early warning, genetic evolution, cross-species transmission and pathogenic mechanisms, and comprehensive biosafety control strategies of Influenza virus, coronavirus and other emerging viral diseases.

 Active early warning research of viruses: explore mutated or new influenza viruses or other emerging viruses, study their gene evolution and origins, epidemic distribution, host range, pathogenicity and transmission ability, and combined with human environment and other factors to warn the risk of virus epidemic and outbreak.

 Pathogenesis and transmission mechanism of viruses: establish cellular and animal infection models to study the molecular basis of the altered host specificity, pathogenicity and transmission ability of viruses, such as variant or new influenza viruses.

 Comprehensive biosafety control strategies: updating or establishing detection methods based on the discovery of variant or new viruses; designing vaccine and drug targets based on the establishment of infection model and the clarification of pathogenic mechanism; and developing comprehensive biosafety control strategies based on the pathogenic characteristics of virus infection and existing prevention and control methods.

It provides theoretical basis and technical support for high-energy early warning of new virus epidemic and outbreak, elucidation of pathogenic and transmission mechanism, and formulation of comprehensive biosafety prevention and control strategies.

Duan Xuefeng  Associate Professor

Yang Jing          Associate Professor

Chen Yuhai       Assistant Professor

Li Pan                Research  Assistant

Li Jiaming          Postdoc

Sun Ju                Postdoc

2021.04-Present: Director, Biosafety and Animal Experiment Platform (former biosafety level III Laboratory), Institute of Microbiology, Chinese Academy of Sciences;

2019.07-Present: Professor, Institute of Microbiology, Chinese Academy of Sciences;

2018.07-Present: Deputy Director of Influenza Research and Early Warning Center, Chinese Academy of Sciences;

2013.06-Present: Influenza Technology Platform Leader, Institute of Microbiology, Chinese Academy of Sciences;

2017.09-2021.04: Deputy Director of biosafety Level III Laboratory, Institute of Microbiology, Chinese Academy of Sciences;

2015.09-2019.06: Associate Professor, Institute of Microbiology, Chinese Academy of Sciences;

2010.07-2015.08: Assistant Professor, Institute of Microbiology, Chinese Academy of Sciences.

1. 2023/2024, Highly Cited Researcher ;

2. 2024,“Outstanding Contributor Award”of Chinese Association of Animal Science and Veterinary Medicine, Animal Infectious Diseases and Veterinary Public Health Branch；

3. 2023, World top 2% scientists;

4. 2023, “Academic Innovation Award” of Chinese Association of Animal Science and Veterinary Medicine, Poultry Diseases Branch；

5. 2022, “Young Scientist Award ”of China Experimental Zoology;

6. 2020,“ Innovation Breakthrough Award” of Zhongyuan Union Life Medicine;

7. 2019, “The second prize of Natural Science Award” of Shandong Province for the research on the Transmission and Evolution of New and Reemerging Avian Influenza Virus in China;

8. 2019, Nominated for the 2019 APEC Science Prize for Innovation, Research and Education (ASPIRE Prize);

9. 2017,  “First Prize of Science and Technology Award” of Chinese Preventive Medicine Association.

1. 2024,National Natural Science Foundation of China (NSFC) “National Outstanding Youth Fund”;

2. 2023, Chinese Academy of Sciences Support Youth Team Project in basic research;

3. 2022, selected acute respiratory infections and emerging respiratory infectious diseases innovative integrated Chinese and Western medicine team;

4. 2021, outstanding member of the Chinese Academy of Sciences Youth Innovation Promotion Association;

5. 2018, National Natural Science Foundation of China (NSFC) “Outstanding Young Scholars”;

6. 2017, Member of Youth Innovation Promotion Association of CAS.

1. Post Professor, University of Chinese Academy of Sciences;

2. Experts of the Secretary-General of the United Nations Using Biological Weapons (United Nations Secretary-General's Mechanism, UNSGM);

3. Director of Chinese Association of Animal Science and Veterinary Medicine, Director of Poultry Diseases Branch, standing Director of Society of Animal Infectious Diseases and Veterinary Public Health Branch, Chairman of Youth Professional Group of Society of Animal Infectious Diseases.

1. Influenza A and B influenza viruses and Novel coronavirus triple (with internal reference) identification test kit (fluorescent PCR), approved for market application (National Equipment Note: 20233401121).

1.        Bi Yuhai, Yang Jingru, Ju Sun, Zhang Ning, Yang Jing; H1N1 influenza virus cold-adapted vaccine skeleton strain CV2-PR8 and its construction method and application；ZL202310662031.2.  

2.        Yang Limin, Fan Wenhui, Liu Wenjun, Bi Yuhai；The invention relates to a novel coronavirus antibody with broad-spectrum neutralizing activity and a preparation method and application thereof；ZL202111591859.0.  

3.        Rao Lei, Yang Dong, Liao Xiaojun, Bi Yuhai, Ning Peng; A method of killing coronavirus on the surface of an outer packaging material encapsulating a cold chain product;ZL202111636656.9.

# First author, * corresponding author;Impact Factor in 2023.

1. Ju Sun#, Tianyi Zheng#, Mingjun Jia#, Yanjun Wang, Jingru Yang, Yun Liu, Pengyun Yang, Yufeng Xie, Honglei Sun, Qi Tong, Jiaming Li, Jing Yang, Guanghua Fu, Yi Shi, Jianxun Qi, Wenjun Liu, Jinhua Liu, Wen-xia Tian*, George F Gao*, Yuhai Bi*. Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus. Nature Communications (NAT COMMUN). 2024 Nov 19. 15(1):10012. doi: 10.1038/s41467-024-54374-z.(IF 2023=14.7, Top 5.6%)

2. Jing Yang, Yuhuan Gong, Chunge Zhang, Ju Sun, Gary Wong, Weifeng Shi, Wenjun Liu, George F. Gao and Yuhai Bi*. Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges. The Innovation (Innovation (Camb)). 2022 Aug 17;3(5):100306. doi: 10.1016/j.xinn.2022.100306.

3. Hong Zhou#, Jingkai Ji#, Xing Chen#, Yuhai Bi#, Juan Li, Qihui Wang, Tao Hu, Hao Song, Runchu Zhao, Yanhua Chen, Mingxue Cui, Yanyan Zhang, Alice C. Hughes*, Edward C. Holmes*, and Weifeng Shi*. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. Cell. 2021 Aug 19;184(17):4380-4391. e14. doi: 10.1016/j.cell.2021.06.008. Epub 2021 Jun 9. (IF 2023=45.5, Top 0.5%)

4. Yuhai Bi # *, Juan Li#, Shanqin Li#, Guanghua Fu#, Tao Jin#, Cheng Zhang, Yongchun Yang, Zhenghai Ma, Wenxia Tian, Jida Li, Shuqi Xiao, Liqiang Li, Renfu Yin, Yi Zhang, Lixin Wang, Yantao Qin, Zhongzi Yao, Fanyu Meng, Dongfang Hu, Delong Li, Gary Wong, Fei Liu,Na Lv, Liang Wang, Lifeng Fu, Yang Yang, Yun Peng, Jinmin Ma, Kirill Sharshov, Alexander Shestopalov, Marina Gulyaeva, George F. Gao, Jianjun Chen, Yi Shi, William J. Liu, Dong Chu, Yu Huang, Yingxia Liu, Lei Liu, Wenjun Liu, Quanjiao Chen*, Weifeng Shi*. Dominant subtype switch in avian influenza viruses during 2016–2019 in China. Nature Communications (NAT COMMUN). 2020 Nov 20;11(1): 5909. doi: 10.1038/s41467-020-19671-3.(IF 2023=14.7, Top 5.6%)

5. Liang Wang, Xavier Didelot, Jing Yang, Gary Wong, Yi Shi, Wenjun Liu, George F. Gao & Yuhai Bi*. Inference of person-to-person transmission of COVID-19 reveals hidden super-spreading events during the early outbreak phase. Nature Communications (NAT COMMUN). 2020, Published: 2020 Oct 6;11(1):5006. doi: 10.1038/s41467-020-18836-4. (IF 2023=14.7, Top 5.6%)