Principal Investigators
State Key Laboratory of Microbial Resources
State Key Laboratory of Mycology
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
CAS Key laboratory of Pathogenic Microbiology & Immunology
The Laboratory of Microbiome and Microecological Technology
The Center for Microbial Resource and Big Data-
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
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Principal Investigator,Professor :

CUI Yinglu
Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China
Telephone/fax：010-64806185
E-mail：cuiyinglu@im.ac.cn
Research Interests
1.AI for enzyme design
2.Utilization of non-natural carbon and nitrogen sources
Education/degrees
2010-2015 Ph.D., Jilin University, Changchun, China
2006-2010 B.S., Jilin University, Changchun, China
Work experience
2024-Present Principle Investigator, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
2021-2024 Associate Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
2017-2021 Assistant professor, Institute for Microbiology, Chinese Academy of Sciences, Beijing, China
2015-2017 Postdoc, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
Awards
2024 The National Natural Science Foundation of China (NSFC) “Excellent Young Investigator
The main research areas
Computational enzyme redesign

The GRAPE strategy for protein stability improving (ACS Catal. 2021)

Biodegradation of plastics

PET biodegradation (Nat Commun. 2024)
Publication
1.Yinglu Cui#*, Yanchun Chen#, Jinyuan Sun#, Tong Zhu#, Hua Pang, Chunli Li, Wen-Chao Geng, Bian Wu*. Computational redesign of a hydrolase for nearly complete PET depolymerization at industrially relevant high-solids loading, Nature Communications, 2024, 15: 1417.
 2.Yue Tang#, Xiaoying Tian#, Min Wang#, Yinglu Cui#, Yang She#, Zhaoxiang Shi, Jiaqi Liu,Huijin Mao, Lilu Liu, Chao Li, Yuwei Zhang, Pengwei Li, Yue Ma, Jinyuan Sun, Qing Du, Jie Li, Jun Wang, De-feng Li, Bian Wu*, Feng Shao*, Yihua Chen*. The β-d-manno-heptoses are immune agonists across kingdoms. Science, 2024, 385: 678-684.
3.Yinglu Cui, Jinyuan Sun, Bian Wu*. Computational enzyme redesign: large jumps in function, Trends in Chemistry, 2022, 4(5): 409-419.
4.Yinglu Cui#, Yinghui Wang#, Wenya Tian#, Yifan Bu, Tao Li, Xuexian Cui, Tong Zhu, Ruifeng Li, Bian Wu*. Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign, Nature Catalysis, 2021, 4: 364-373.
5.Yinglu Cui#, Yanchun Chen#, Xinyue Liu, Saijun Dong, Yu’e Tian, Yuxin Qiao, Ruchira Mitra, Jing Han, Chunli Li, Xu Han, Weidong Liu, Quan Chen, Wangqing Wei, Xin Wang, Wenbin Du, Shuangyan Tang, Hua Xiang, Haiyan Liu, Yong Liang, Kendall N. Houk, Bian Wu. Computational redesign of a PETase for plastic biodegradation under ambient condition by the GRAPE strategy, ACS Catalysis, 2021, 11(3): 1340-1350.