Zhang Shouyue----微生物研究所

CAS Key laboratory of Microbial Physiological and Metabolic Engineering

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Principal Investigator,Professor :

Zhang Shouyue

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：

E-mail：zhangshouyue(at)im.ac.cn Please replace (at) with @ for contact

Research Interests

1. Bioinformatics: Design, training, and optimization of large-scale deep learning models for microbial genomes. Mining and designing biomolecular components (long non-coding RNAs or proteins).

2. Structural and Molecular Biology: Analyzing the structure and function of biomolecular components (long non-coding RNAs or proteins), exploring the mechanisms of molecular evolution, and developing tools for biomanufacturing (synthetic biology or gene editing).

Education/degrees

2012-2016 B.S., Sichuan University, Chengdu, China

2016-2020 Ph.D., Sichuan University, Chengdu, China

Work experience

2020-2024 Postdoc Fellow in Dr. Jun-Jie Gogo Liu’s Lab, Tsinghua University, Beijing, China

2024-Present Principal Investigator, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

The main research areas

Developed a "Structural Growth Trajectory" analysis method. Discovered the growth and evolutionary trajectory of the Cas9 protein component in the CRISPR-Cas9 system, and for the first time identified that Cas9 can collaborate with a type of CRISPR-enhancing protein (Pro-CRISPR) to boost its activity. (Nature, 2024, DOI: 10.1038/s41586-024-07486-x)

Developed a bioinformatics identification method called "Single-Species Multi-Copy Approach," which successfully identified highly active Group II intron ribozymes in prokaryotic genomes that are composed entirely of RNA elements without any protein components. (Science, 2024, DOI: 10.1126/science.adh4859)

Publication

1. Zhang S^#, Sun A^#, Qian JM^#, Lin S^#, Xing W, Yang Y, Zhu HZ, Zhou XY, Guo YS, Liu Y, Meng Y, Jin SL, Song W, Li CP, Li Z, Jin S, Wang JH, Dong MQ, Gao C, Chen C*, Bai Y*, and Liu JJG*. Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature. 2024, 630:484-492.

2. Liu Z^#, Zhang S^#, Zhu HZ^#, Chen ZH^#, Yang Y^#, Li LQ^#, Lei Y, Liu Y, Li DY, Sun A, Li CP, Tan SQ, Wang GL, Shen JY, Jin S, Gao C, and Liu JJG*. Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage. Science. 2024, 383:495-495.

3. Tsuchida CA^#, Zhang S^#, Doost MS^#, Zhao Y^#, Wang J, O'Brien E, Fang H, Li CP, Li D, Hai ZY, Chuck J, Broetzmann J, Vartoumian A, Burstein D, Chen XW, Nogales E, Doudna JA*, and Liu JJG*. Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. Molecular Cell. 2022, 82:1199-1209.e6.

4. Sun A^#, Li CP^#, Chen Z^#, Zhang S^#, Li DY, Yang Y, Li LQ, Zhao Y, Wang K, Li Z, Liu J, Liu S, Wang J*, and Liu JJG*. The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation. Cell Research. 2023, 33:229-244.