Principal Investigator,Professor : Group of Molecular Genetics and Physiological & Metabolic Engineering of Yeast

HE Xiuping
Address:NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China
Telephone/fax:010-64807427
E-mail:hexp@im.ac.cn
Research Interests
Molecular Genetics and Physiological & Metabolic Engineering of Yeast
1.Understanding the adaptive response and tolerance to various stresses from molecular level and improving the robustness of yeast cells in fermentation process.
2.Development of effective tools for genome editing and transcriptional control of yeast and efficient platforms for recombinant proteins production.
3.Design and engineering yeast cells to improve the yields or synthetic efficiencies of value-added compounds.
Education/degrees
Ph.D. in Genetics. June 2003. Institute of Microbiology, Chinese Academy of Sciences
M.S. in Biochemistry. June 1996. NanKai University, Tianjin, China
B.S. in Agronomy. June 1989. China Agricultural University, Beijing, China
Work experience
2011-present Professor, Institute of Microbiology, Chinese Academy of Sciences
2003-2011 Associate Professor, Institute of Microbiology, Chinese Academy of Sciences
1996-2003 Institute of Microbiology, Chinese Academy of Sciences
1989-1993 HeBei North University
The main research areas
Molecular genetics of yeast, Yeast expression system for recombinant protein production, Yeast cell factories for efficient production of high-value-added compounds, Development of functional microbial inoculum

Publication
1. Zhou CY, Li MJ, Lu SR, Cheng YF, Guo XN, He XX, Wang ZY, He XP.* (2021). Engineering of cis-element in Saccharomyces cerevisiae for efficient accumulation of value-added compound squalene via downregulation of the downstream metabolic flux. J Agric Food Chem, 69(42): 12474-12484.
2. Cheng YF, Zhu H, Du ZD, Guo XN, Zhou CY, Wang ZY, He XP.* (2021) Eukaryotic translation factor eIF5A contributes to acetic acid tolerance in Saccharomyces cerevisiae via transcriptional factor Ume6p. Biotechnol for Biofuels, 14(1): 38.