Principal Investigator,Professor :

Address:NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China
Research Interests
Our research group is committed to studying the mechanisms of bacterial resistance and phage prevention strategies. We aim to uncover the resistance mechanisms of clinical and environmental bacteria, discover new resistance genes or mechanisms, and elucidate the transfer and dissemination mechanisms of resistance genes, providing a theoretical basis for controlling bacterial resistance.
Simultaneously, with an in-depth understanding of bacterial resistance mechanisms, we focus on phages that can eliminate multidrug-resistant bacteria. We establish a phage resource library to lyse different serotypes and sequence types of pathogenic bacteria (such as Klebsiella pneumoniae), revealing the interaction between pathogenic bacterial receptors and phage receptor binding proteins. We further study new mechanisms of pathogenic bacterial defense and phage anti-defense, providing new ideas and strategies to solve the problems of phage narrow spectrum and resistance.
Ultimately, the study of bacterial resistance mechanisms and phage prevention strategies will lay a theoretical foundation and provide technical support for controlling the increasingly serious problem of bacterial resistance.
2002-2006 Ph.D. in Microbiology, Institute of Microbiology, Chinese Academy of Sciences
1998-2001 Master of science, Food Microbiology, Shandong Agricultural University
Work experience
2017-Present Principal Investigator, Professor of Microbiology, Institute of Microbiology, Chinese Academy of Sciences
2009-2017 Principal Investigator, Associate professor, Institute of Microbiology, Chinese Academy of Sciences
2006-2009 Post-doctor, Infectious Disease Research Centre, Laval University, Canada
The main research areas
Microbial resistance and bacteriophage prevention
1. Yao Shigang#, Wu Xinyi#, Li Y, Song Y, Wang C, Zhang Gang*, Feng Jie*. Harnessing the native type I-F CRISPR-Cas system of Acinetobacter baumannii for genome editing and gene repression. Int J Antimicrob Agents. 2023 Sep 4;62(5):106962.
2. Zeng Yuan#, Song Yuqin#, Cui Lanqing#, Wu Q, Wang C, Coelho AC, Zhang G, Wei D, Li C, Zhang J, Corbeil J, Li Yun*, Feng Jie*. Phylogenomic insights into evolutionary trajectories of multidrug resistant S. pneumoniae CC271 over a period of 14 years in China. Genome Med. 2023 Jul 4;15(1):46.
3. Zhang Gang#, Yao Shigang#, Liu Yunan, Fang Hailing, Song Yuqin, Wang,Chao Wei Dawei, Feng Jie *. Systematic discovery of a new catalogue of tyrosine-type integrases in bacterial genomic islands. Appl Environ Microbiol. 2023 Feb 28;89(2):e0173822.
4. Yao Shigang, Wei Dawei, Tang Na, Song Yuqin, Wang Chao, Feng Jie*, Zhang Gang*. Efficient suppression of natural plasmid-borne gene expression in carbapenem-resistant Klebsiella pneumoniae using a compact CRISPR interference system. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0089022.
5. Yang Jing#, Li Yi#, Tang Na#, Li J#, Zhou J, Lu S, Zhang G, Song Y, Wang C, Zhong J, Xu J*, Feng Jie*. The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae. Gut Microbes. 2022 Jan-Dec;14(1):2114739.
6. Wei Dawei#, Wong N#, Song Y, Zhang G, Wang C, Li J, Feng Jie*. IS26 veers genomic plasticity and genetic rearrangement toward carbapenem hyperresistance under sublethal antibiotics. mBio. 2022 Feb 8;13(1):e0334021.
7. Tang Na#, Hu J#, Zhao Y, Song Y, Wang C, Zhang G, Wei D, Fang H, Li C, Jia R, Feng Jie*. In vivo evolution of carbapenem resistance in hypervirulent Klebsiella pneumoniae in a patient undergoing long-term treatment. J Antimicrob Chemother. 2022 Feb 2;77(2):531-533.
8. Zhang Gang#, Li Jianjuan#, Ai Guomin, He Jialiang, Wang Chao*, Feng Jie*. A new intrinsic aminoglycoside 6'-N-acetyltransferase subclass, AAC(6')-III, in Burkholderia pseudomallei, Burkholderia mallei, and Burkholderia oklahomensis. J Antimicrob Chemother. 2020 May 1;75(5):1352-1353.
9. Zhang Chaodong#, Ju Yingjiao#, Tang Na#, Li Yun, Zhang Gang, Song Yuqin, Fang Hailing, Yang Liang*, Feng Jie*. Systematic analysis of supervised machine learning as an effective approach to predicate β-lactam resistance phenotype in Streptococcus pneumoniae. Brief Bioinform. 2020 Jul 15;21(4):1347-1355.
10. Zhang Gang, Sun Kaiwen, Ai Guomin, Li Jianjuan, Tang Na, Wang Chao*, Feng Jie*. A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: naturally occurring variants reveal diverse resistance levels against chloramphenicol. Inter J Antimicrob Agents. 2019 Mar 13. pii: S0924-8579(19)30065-2.
11. Du Xiaochen#, Bayliss Sion C#, Feil Edward J, Liu Ying, Wang Chao, Zhang Gang, Zhou Dongsheng, Wei Dawei, Tang Na, Leclercq Sébastien O, Feng Jie*. Real time monitoring of Aeromonas salmonicida evolution in response to successive antibiotic therapies in a commercial fish farm. Environ Microbiol. 2019 Jan 13. doi: 10.1111/1462-2920.14531.
12. Tian Jingjing#, Zhang Gang#, Ju Y, Tang Na, Li Jianjuan, Jia Rufu, Feng Jie*. Five novel carbapenem-hydrolysing OXA-type β-lactamase groups are intrinsic in Acinetobacter spp. J Antimicrob Chemother. 2018, 73(12):3279-3284.
13. Zhang Gang, Leclercq Sebastien Olivier, Tian Jingjing, Wang Chao, Yahara Koji, Ai Guomin, Liu Shuangjiang, Feng Jie*. A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination. PLoS Genet (PLOS Genetics). 2017 Feb 2; 13(2): e1006602.
14. Leclercq SO#, Wang C#, Sui Z, Wu H, Zhu B, Deng Y, Feng Jie*. A multiplayer game: species of Clostridium, Acinetobacter, and Pseudomonas are responsible for the persistence of antibiotic resistance genes in manure-treated soils. Environ Microbiol. 2016 Oct;18(10):3494-3508.
15. Zhang Gang, Tian Jingjing, Wang Chao, Chen Jifeng, Feng Jie*. Identification of novel cryptic aminoglycoside phosphotransferases in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016, 60(11):6983-6985.
16. Zhang Gang, Wang Chao, Sui Zhihai, Feng Jie*. Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2015, 70(9): 2499-2506.
17. Wang Chao#, Sui Zhihai#, Sébastien Olivier Leclercq, Zhang Gang, Zhao Meilin, Chen Weiqi, Feng Jie*. Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the Bacillus cereus group. Environ Microbiol. 2015, 17(5): 1560-1573.
18. Zhou Wenqing, Yao Kaihu, Zhang Gang, Yang Yonghong, Li Yun, Lv Yuan, Feng Jie*. Mechanism for transfer of transposon Tn2010 carrying macrolide resistance genes in Streptococcus pneumoniae and its effects on genome evolution. J Antimicrob Chemother. 2014, 69(6): 1470-1473.
19. Yang Jing#, Wang Chao#, Wu Jinyu, Liu Li, Zhang Gang, Feng Jie*. Characterization of a multiresistant mosaic plasmid from a fish farm sediment Exiguobacterium sp. isolate reveals aggregation of functional clinic-associated antibiotic resistance genes. Appl Environ Microb. 2014, 80(4): 1482-1488.
20. Zhang Gang#, TianWenyu#, Wang Chao, Feng Jie*. Identification of a novel resistance mutation in parE that confers high-level resistance to moxifloxacin in Streptococcus pneumoniae. J Antimicrob Chemother. 2012, 67(11): 2773-2774.