Lin Xiao----微生物研究所

State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)

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Principal Investigator,Professor : oomycete genomics and host immunity

Lin Xiao

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：

E-mail：linx@im.ac.cn

Research Interests

Oomycete pathogens can cause many plant diseases, like the notorious potato late blight. To find a genetic solution to plant diseases, we will collect and evaluate the wild relatives of crops. We will use pathogen effectors as a tool, hunt for R genes from these wild plants and ultimately apply them in crops.

Education/degrees

Ph.D 2013-2018 Plant Breeding, Wageningen UR, the Netherlands
MSc 2010-2013 Plant Genomics, Huazhong Agricultural University, Wuhan, China
BSc 2006-2010 Biological Science, Huazhong Agricultural University, Wuhan, China

Work experience

2018-2023 Postdoctral Scientist, The Sainsbury Laboratory, Norwich, UK

The main research areas

1.mycete genomics and effectoromics
2.Cloning and applying new plant immune receptors
3.Molecular mechanism of plant-microbe interaction

Publication

Lin, X.#*, Jia, Y#., Heal, R., Prokchorchik, M., Sindalovskaya, M., Olave-Achury, A., et al. (2022). The Solanum americanum pangenome and effectoromics reveal new resistance genes against potato late blight. BioRxiv, 2022.08.11.503608. doi:10.1101/2022.08.11.503608.

Ahn, H.K.#, Lin, X#., Olave-Achury, A.C., Derevnina, L., Contreras, M.P., Kourelis, J., Kamoun, S. and Jones, J.D.G. (2023) Effector-dependent activation and oligomerization of NRC helper NLRs by Rpi-amr3 and Rpi-amr1. The EMBO Journal. (Co-first author)

Lin X, Olave-Achury A, Heal R, Witek K, Karki HS, Song T, Wu CH, Adachi H, Kamoun S, Vleeshouwers VGAA, Jones JDG (2022) A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector. Molecular Plant. Doi: https://doi.org/10.1016/j.molp.2022.07.012

Witek K#, Lin X#, Karki HS#, Jupe F, Witek AI, Steuernagel B, Stam R, van Oosterhout C, Fairhead S, Cocker JM, Bhanvadia S, Barrett W, Wu C-H, Adachi H, Song T, Kamoun S, Vleeshouwers VG, Tomlinson L, Wulff BB, Jones JDG (2021) A complex non-host resistance locus in Solanum americanum recognizes a conserved Phytophthora effector. Nature plants. 7, 198-208 (Co-first author)

Lin X, Wang S, de Rond L, Bertolin N, Wouters RHM, Wouters D, Domazakis E, Bitew MK, Win J, Dong S, et al (2020) Divergent Evolution of PcF/SCR74 Effectors in Oomycetes Is Associated with Distinct Recognition Patterns in Solanaceous Plants. MBio 11: 380

Lin X, Armstrong M, Baker K, Wouters D, Visser RGF, Wolters PJ, Hein I, Vleeshouwers VGAA. (2020). RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes. New Phytologist 227:1264-1276

Lin X, Song T, Fairhead S, Witek K, Jouet A, Vleeshouwers VGAA, Hein I, Jones JDG (2020) Identification of Avramr1 from Phytophthora infestans using long read and cDNA pathogen-enrichment sequencing (PenSeq). Molecular Plant Pathology. 00:1-12. doi: https://doi.org/10.1111/mpp.12987

X Lin*, JDG Jones* (2020) RNA Splicing: A Novel Pathogen Effector Target. Molecular Plant. 13 (10), 1348

Xiao Lin, Yu Zhang, Hanhui Kuang and Jiongjiong Chen (2013) Frequent loss of lineages and deficient duplications accounted for low copy number of disease resistance genes in Cucurbitaceae. BMC genomics 14:335