Principal Investigator,Professor : Epigenetic regulation for fungi and plant-pathogen interaction lab

Shan Chunmin
Address:NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China
Research Interests
Our lab’s research mainly focuses on the regulation of constitute epigenetic “memories” of gene expression, which is essential to ensure faithful inheritance of cell identity, using model fungi like fission yeast. We also are interested in how the fungi-plant interaction is epigenetically regulated, as well as the effects of environmental factors.
B.S. 2007 Nanjing University
Ph.D 2014 University of Chinese Academy of Sciences/Shanghai Institutes of biological Sciences, Chinese Academy of Sciences
Work experience
2014-2019 Postdoctral Research Scientist, Columbia University, USA
2019-2021 Associate Research Scientist, Columbia University, USA
2021-now Principal Investigator, Institute of Microbiology, Chinese Academy of Sciences
The main research areas
I Mechanism of epigenetic inheritance
II Epigenetic regulation of fungi-plant interaction


1.Shan CM, Fang Y, Jia S* (2021) Leaving histone unturned for epigenetic inheritance (Invited review). The FEBS Journal, accepted.

2.Shan CM, Kim JK, Wang J, Bao K, Sun Y, Chen H, Yue JX, Stripe A, Schalch T, Liti G, Nagy PL, Tong L, Qiao F, Jia S* (2021) Mechanism for the selective sequestration of a histone H3K9 methyltransferase at heterochromatin by the H3K9M mutation. Cell Reports; 35:109137;

3.Shan CM, Bao K, Diedrich J, Chen X, Chao Lu, Yates JR, Jia S*. (2020) The INO80 complex regulates epigenetic inheritance of heterochromatin. Cell Reports; 33:108561; doi:10.1016/j.celrep. 2020.108561.

4.Bao KH#, Shan CM#, Moresco JJ, Yates JR, Jia S*.(2018)  Antisilencing factor Epe1 recruits SAGA to promote transcription within heterochromatin Genes and Development; 33(1-2): 116–126.  

5.Zhang Y#, Shan CM#, Wang J#, Bao K, Tong L*, Jia S*. (2017) Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. Scientific Reports 7, 43906; doi: 10.1038/srep43906.

6.Shan CM#, Wang J#, Xu K#, Chen H, Yue JX, Andrews S, Moresco JJ, Yates JR, Nagy PL, Tong L*, Jia S*. (2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. eLife; doi: 10.7554/eLife.17903

7.Shan CM, Shangguan XX, Zhao B, Zhang XF, Chao L, Yang CQ, Wang LJ, Zhu HY, Zen YD, Guo WZ, Zhou BL, Hu GJ, Guan XY, Chen ZJ, Wendel JF, Zhang TZ*, Chen XY.* (2014) Control of cotton fiber elongation by a homeodomain transcription factor, GhHOX3. Nature Communications; 5:5519; doi: 10.1038/ncomms6519. 

8.Cao JF#, Zhao B#, Huang CC, Chen ZW, Zhao T, Liu HR, Hu GJ, Shangguan XX, Shan CM, Wang LJ, Zhang TZ, Wendel JF, Guan XY, Chen XY* (2020) The miR319-targeted GhTCP4 promotes the transition from cell elongation to wall thickening in cotton fiber. Molecular Plant 13 (7), 1063-1077

9.Liu X#, Zhao B#, Zheng HJ#, Hu Y#, Lu G, … Shan CM, Jiang JP, Zhu YQ, ... Zhang GY*, Wang SY, Zhang TZ*, Zhao GP, Chen XY* (2015) Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites. Scientific Reports 5:14139;  

10.Yu ZX, Wang LJ, Zhao B, Shan CM, Zhang YH, Chen DF, and Chen XY*. (2015) Progressive regulation of sesquiterpene biosynthesis in Arabidopsis inflorescence by the miR156-Targeted SPL transcription factors. Molecular Plant 8 (1), 98-110

11.Yu N#, Cai WJ#, Wang SC, Shan CM, Wang LJ, Chen XY*  (2010) Temporal control of trichome distribution by microRNA156-targeted SPL Genes in Arabidopsis thaliana. The Plant Cell 22: 2322–2335.

12.Guan XY, Li QJ, Shan CM, Wang S, Mao YB, Wang LJ, Chen XY* (2008) The HD-Zip IV gene GaHOX1 from cotton fiber is a functional homologue of the Arabidopsis GLABRA2 gene. Physiologia Plantarum. 134: 174–182