a.Determining the function role of m6A reader proteins in various immunosuppressive cells, elucidating the molecular mechanisms, and developing relevant ADC therapy strategies. 

b.Identifying specific microbial metabolite for inhibiting m6A reader proteins and developing relevant engineered probiotic to overcome extrinsic resistance to radio-immunotherapy.

2016.08 – 2019.08, Postdoctoral Researcher, Tsinghua University, Beijing, China. 

2019.09 – 2021.08, Postdoctoral Scholar, University of Chicago, Chicago, IL, USA. 

2021.08 – 2023.06, Staff Scientist, University of Chicago, Chicago, IL, USA. 

2023.07 – 2024.07, Research Assistant Professor, University of Chicago, Chicago, IL, USA. 

2024.08 – Present, Principal Investigator, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

My research group will aim to fully elucidate the relationship between RNA m6A-associated proteins and extrinsic resistance to radiotherapy and immunotherapy, to identify the optimal targets, and finally to develop precision biomedical approaches to boost current cancer therapies. My group will also focus on understanding the interplay between microbial metabolite and m6A methylation changes in host immune cells, and then will utilize this information for bacteria (probiotic)-engineering strategies to enhance antitumor immunity.

1. Wang L, Lynch C, Pitroda SP, Piffkó A, Yang K, Huser AK, et al. Radiotherapy and immunology. J Exp Med. 2024;221(7):e20232101.
2. Bugno J^#, Wang L^#, Yu X, Cao X, Wang J, Huang X, et al. Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance. Clin Cancer Res. 2024;CCR-23-3616.
3. Wang L^#*, Si W^#, Yu X^#, Piffko A, Dou X, Ding X, et al. Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance. J Clin Invest. 2023;133(24):e172919.
4. Wang L^#*, Katipally RR, Liang HL, Yang K, Pitroda SP, He C, Weichselbaum RR*. RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy. Med. 2023;4(12):863-874.
5. Wang L^#, Dou X^#, Chen S^#, et al, Luo C*, Liang HL*, He C*, Weichselbaum RR*. YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. Cancer Cell. 2023;41(7):1294-1308.e8.
6. Si W, Liang H, Bugno J, et al, Weichselbaum RR, Zhao X, Wang L*. Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade. Gut. 2022;71(3):521-533.
7. He L#, Wang L^#, Wang Z^#, et al, Dimitrov DS, Du J*, Liao X*. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64(21):15716-15726.
8. Ding XC^#, Wang LL^#, Zhang XD, et al, Weichselbaum RR*, Yu JM*, Hu M*. The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia. J Hematol Oncol. 2021;14(1):92.
9. Wang L#, Gao Y^#, Zhang G#, Li D#, et al, Hu X*, Wei Z*, Wang W*, Liao X*. Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. Sci Transl Med. 2020;12(560):eaax2282.
10 .Wang L^#, Si W^#, Xue H, Zhao X*. Characterization of a functional insertion sequence ISSau2 from Staphylococcus aureus. Mobile DNA. 2018;16;9:3.
11. Wang L, Si W, Xue H, Zhao X*. A fibronectin-binding protein (FbpA) of Weissella cibaria inhibits colonization and infection of Staphylococcus aureus in mammary glands. Cellular Microbiology. 2017;19(8).
12. Wang L, Xue H, Li L, Zhao X*. Characterization of insertion sequence ISSau2 in the human and livestock-associated Staphylococcus aureus. PLoS One. 2015;15;10(5):e0127183.