Principal Investigators
State Key Laboratory of Microbial Resources
State Key Laboratory of Mycology
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
CAS Key laboratory of Pathogenic Microbiology & Immunology
The Center for Microbial Resource and Big Data-
CAS Key laboratory of Pathogenic Microbiology & Immunology
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Principal Investigator,Professor : Viral Replication and Cell Cycle Regulation

LIU Ningning
Title：PhD, Professor
Dept.:CAS Key Laboratory of Pathogenic Microbiology and Immunology
Address：NO.1 Beichen West Road, Chaoyang District, Beijing 100101, P. R. China
Telephone/fax：+86-10-
E-mail：liunn@im.ac.cn nnliu01@hotmail.com

Research Interests
1. Liver immune microenvironment regulatory mechanism responding to acute and chronic viral infections.
2. Hepatic glucose and lipid metabolism during viral infection, liver fibrosis, cirrhosis to hepatocellular carcinoma.
 
Education/degrees
2011-2014 Ph.D. Institute of Microbiology, University of Chinese Academy of Sciences
2008-2011 M.S. Shandong Agricultural University 
2004-2008 B.S. Shandong Agricultural University
 
Work experience
2022.11- Professor, Institute of Microbiology, CAS, China
2021-2022 Instructor, UT Southwestern Medical Center, USA
2017-2021 Postdoctoral Associate, University of Minnesota, USA
2014-2017 Assistant professor, Institute of Microbiology, Chinese Academy of Sciences, China
 
Awards
2021 CALS Postdoctoral Fellow Research Award
2021 Presidential Poster Award, 2021 AASLD Annual Meeting (top 10%)
2020 Poster Presentation Award of the Society of Chinese Bioscientists in America
2020 Presidential Poster Award, 2020 AASLD Annual Meeting (top 10%)
 
The main research areas
Liver specific immune response and lipid metabolic regulation to pathogens.
 
Publication(only show first and co-first author)
[1] Ningning Liu, Clifford J. Steer, and Guisheng Song. MicroRNA-15a/16-1 Prevent Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Regulatory T Cells. Gastroenterology, 2022. PMID: 34678217. 
[2] Ningning Liu, Xiaomei Wang, Clifford J. Steer, and Guisheng Song. MicroRNA-206 Promotes the Recruitment of CD8+ T Cells by Driving M1 Phase Polarization of Kupffer Cells. Gut, 2022. PMID: 34706869. 
[3] Ningning Liu, Clifford J Steer, Guisheng Song. MicroRNA-206 Enhances Antitumor Immunity by Disrupting the Communication between Malignant Hepatocytes and Tregs in c-Myc Mice. Hepatology, 2022. PMID: 34606648. 
[4] Ningning Liu*, Tianpeng Zhang*, Clifford J Steer, Guisheng Song.  MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis. Cell & Bioscience, 2022. PMID: 36457036. *co-first author. 
[5] Ningning Liu*, Qi Liu*, Xiaohai Yang*, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, and Xin Ye. Hepatitis B Virus-Upregulated LNC-HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity. Hepatology, 2018. PMID: 29790592. *co-first author.
[6] Ningning Liu*, Jinfang Zhang*, Xiaohai Yang, Tong Jiao, Xin Zhao, Wenxia Li, Jianhua Zhu, Pu Yang, Jianping Jin, Jirun Peng, Zhiwei Li, and Xin Ye. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx to Enhance its Stability and Function. Journal of Virology, 2017. PMID: 28592528. *co-first author. 
[7] Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, and Xin Ye. Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7-Transforming Growth Factor Beta Pathway. Journal of Virology, 2015. PMID: 25540364.
[8] Ningning Liu, Jinfang Zhang, Tong Jiao, Zhiwei Li, and Xin Ye. Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA-15a/16 Cluster. Journal of Virology, 2013. PMID: 24089558.