Wenjun Liu received his DVM from Beijing Agricultural University in Beijing and Ph.D from the University of Florida in Gainesville, Florida. He had worked at China Agricultural University (1985-1989) and National Animal Disease Center of USDA (1988-1989), Howard Hughes Medical institute/Oklahoma Medical Research Foundation (1998-2001), and Genzyme Corporation (2001-2004). Now he is a professor and deputy director in CAS Key Laboratory of Pathogenic Microbiology of Immunology, Institute of Microbiology, Chinese Academy of Science. He is also the director of Biosafety Level 3 Laboratory, Institute of Microbiology, Chinese Academy of Science. In his research area, Dr. Liu has published nearly 70 research articles and reviews.

His lab focuses on the molecular biology of viruses, the interactions of viruses with host cells, the pathogenesis of viral diseases, the post-translational modification of viral proteins, and mechanisms of host defense. The research works are designed to increase fundamental knowledge as well as to facilitate the development of new approaches to control of viral infection.

1. W-J Chai #, J Li#, Q Shangguan, Q Liu, X-D Li, D-D Qi, X-M Tong, W-J Liu, X Ye*. 2018. Lnc-ISG20 inhibits influenza A virus replication by enhancing ISG20 expression. Journal of Virology. doi: doi:10.1128/JVI.00539-18
2. J Li, K Zhang, Q-Y Chen, X Zhang, Y-P Sun, Y-H Bi, S Zhang, J-Y Gu, J-R Li, Di Liu, W-J Liu*, J-Y Zhou*. 2018. Three Amino Acid Substitutions in the NS1 Protein change the Virus Replication of H5N1 Influenza Virus in Human Cells. Virology. doi: 10.1016/j.virol.2018.04.004
3. Y Li, L Sun*, W-N Zheng, Madina·M, J Li, Y-H Bi, H Wang, W-J Liu*, Luo T*. 2018. Phosphorylation and dephosphorylation of threonine 188 innucleoprotein is crucial for the replication of influenza A virus. Virology. doi: 10.1016/ j.virol.2018.05.002
4. C Chen, W-H Fan, J Li, W-N Zheng, S Zhang, L-Y Yang, D Liu, W-J Liu*, L Sun*. 2018. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. Front. Cell. Infect. Microbiol. 8:127. doi.org/10.3389/fcimb.2018.00127
5. Y-P Sun, J-W Jiang, P Tien, W-J Liu *, J Li*. 2018. IFN-λ: A new spotlight in innate immunity against influenza virus infection. Protein & Cell. doi: 10.1007/s13238-017-0503-6
6. Y-P Sun, J Li*, P Tien, George Fu Gao, W-J Liu*. 2018. Bunyavirales Ribonucleoproteins: the Viral Replication and Transcription Machinery. Critical Reviews in Microbiology. doi: 10.1080/1040841X.2018.1446901
7. J Li, J Lu, S Zhang, Wang J, F Liu, M Fang, X-F Duan*, W-J Liu. 2018. Differential Immune Response of Influenza A Virus-infected Dendritic Cells and Association with Autophagy. Future Virology. 10.2217/fvl-2017-0044.
8. W Liu#, J Li#, W-N Zheng, Y-L Shang, Z-D Zhao, S-S Wang, Y-H Bi, S Zhang, C-F Xu, Z-Y Duan, L-F Zhang, Y Wang, Z-F Jiang, W-J Liu*, L Sun*. 2017. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife, 6(8); 6. pii: e24425
9. J Li, W-N Zheng, L-D Hou, C Chen, W-H Fan, H-R Qu, J-W Jiang, J Liu, George Fu Gao, J-Y Zhou, L Sun*, W-J Liu*. 2016. Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism. Cellular Microbiology. doi: 10.1111/cmi.12692
10. W-N Zheng, S-S Cao, C Chen, J Li, Sh Zhang, J-W Jiang, Y-G Niu, W-H Fan, Y Li, Y-H Bi, George Fu Gao, L Sun*, W-J Liu*. 2016. Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I. Cellular Microbiology. doi:10.1111/cmi.12643.
11. J Li, C Chen, Gary W, W Dong, W-N Zheng, Y Li, L Sun, L-F Zhang, George Fu Gao, Y-H Bi, W-J Liu*. 2016. Cyclophilin A protects mice against infection by influenza A virus. Scientific reports 28978.
12. J-W Jiang, J Li*, W-H Fan, W-N Zheng, M Yu, C Chen, L Sun, Y-H Bi, C Ding, George Fu Gao, W-J Liu*. 2016. Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. Journal of Virology. pii: JVI.00549-16.
13. Y-G Niu, Y Liu, L-M Yang, H-R Qu, J Zhao, R-L Hu, J Li*, W-J Liu*. 2016. Evaluation of the immunogenicity of multi-epitope-based vaccine candidates against rabies adjuvant with Gp96. Virologica Sinica, 4; 31(2):168-75.
14. J Li, Y-H Rao, Q-L Sun, X-X Wu, J Jin, Y-H Bi, J Chen, F-M Lei, Q-Y Liu, Z-Y Duan, J-C Ma, George Fu Gao, D Liu, W-J Liu*. 2015. Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China. Scientific reports, 18094, doi: 10.1038/srep18094
15. J Li, W-J Liu*. 2015. Diversity of the RNA polymerase in the H7N9 Influenza A Virus. Advances in Microbiology, 5: 661-667
16. J Li, T Qin, X-X Jia, A-H Deng, X Zang, W-H Fan, S-D Huo, T-Y Wen, W-J Liu*. 2015. Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy. Biomedical and Environmental Sciences, 2015; 28(6): 77-84
17. X-J Jia, Y-H Bi, J Li, Q Xie, H-C Yang*, W-J Liu*.2015. Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity, Scientific reports, 10651
18. K Zhang #, Z Wang#, G-Z Fan, J Wang, S-Y Gao, Y Li, L Sun, C-C Yin*, W-J Liu*. 2015. Two Polar Residues Within C-terminal Domain of M1 are Critical for the Formation of Influenza A Virus Matrix Layer, Cellular Microbiology (10)1111/cmi.12457
19. J Li, M Yu, W-N Zheng, W-J Liu*. 2015. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins, Viruses 7, 2668-2682.
20. W-N Zheng, J Li, S-S Wang, S Cao, J-W Jiang, C Chen, C Ding, C Qin, X Ye, George Fu Gao, W-J Liu*. 2015. Phosphorylation controls the nuclear-cytoplasmic shuttling of influenza A virus nucleoprotein. Journal of Virology. 3(18). pii: JVI.00015-15.
21. Y-H Bi, Q Xie, S Zhang, Y Li, H-X Xiao, T Jing, WN Zheng, J Li, X-J Jia, L Sun, J-H Liu, C Qin, George F Gao, W-J Liu*. 2014. Assessment of the internal genes of influenza A (H7N9) virus contributing to the high pathogenicity in mice. Journal of Virology. doi:10.1128/JVI.02390-14
22. Y-H Bi, J Li, L-M Yang, S Zhang, Y Li, X-J Jia, L Sun, Y-B Yin, C Qin, B-N Wang, George Fu Gao, W-J Liu*. 2014. Assessment of the pathogenesis of Streptococcus suis type 2 infection in piglets for understanding streptococcal toxic shock-like syndrome, meningitis, and sequelae. Vet Microbiol, doi:10.1016/j.vetmic.2014.08.010
23. Sh Cao#, J-W Jiang#, J Li, Y Li, L-M Yang, Sh-Sh Wang, J-H Yan, George F Gao, W-J Liu*. 2014. Characterization of The Nucleocytoplasmic Shuttle of The Matrix Protein of Influenza B Virus. Journal of Virology.88 (13):7464-7473
24. Sh-Y Gao, Sh-Sh Wang, Sh Cao, L Sun, J Li, Y-H Bi, George F Gao, W-J Liu*. 2014. The characteristics of nucleocytoplasmic transport of H1N1 influenza A viruses nuclear export protein (NEP). Journal of Virology. 88 (13):7455-7463
25. L Xu, L-M Yang, W-J Liu*.2013. Distinct evolution process among type I interferon in mammals. Protein Cell. May;4(5):383-92
26. S-S Wang, Zh-D Zhao, Y-H Bi, L Sun, X-L Liu*, W-J Liu*.2013. Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling its nuclear import. Journal of Virology, 87(11):6182-91
27. J Li, Y-H Bi, C Chen, L-M Yang, W-J Liu*. 2013. Genetic characterization of Duck Hepatitis A Viruses isolated in China. Virus Research. (doi:10.1016/j.virusres.2013.10.007)
28. X-L Liu, Zh-D Zhao, W-J Liu*.2013. Insights into the Roles of Cyclophilin A during Influenza Virus Infection. Viruses. 5:182-191
29. L-M Yang, J-Y Cen, Q-H Xue, J Li, Y-H Bi, L Sun, W-J Liu*.2013. Identification of Rabies Virus Mimotopes Screened from a Phage Display Peptide Library with Purified Dog Anti-Rabies Virus Serum IgG.. Virus Research. 174:47-51
30. H-R Qv#, L-M Yang#, S-S Meng, L Xu, Y-H Bi, X-J Jia, J Li, L Sun, W-J Liu*.2013. The Differential Antiviral Activities of Chicken Interferon α (ChIFN-α) and ChIFN-β Are Related to Distinct Interferon-stimulated Gene Expression, PLoS One. (doi: 10.1371/journal.pone.0059307)
31. C-W Chen, J Li, Y-H Bi, L-M Yang, S-S Meng, Y-C Zhou, X-J Jia, S-D Meng, L Sun, W-J Liu*.2013. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity, Vaccine. (doi: http://dx.doi.org/10.1016/j.vaccine.2013.01.049)
32. C-W Chen, W-H Fan, X-J Jia, J Li, Y-H Bi, W-J Liu* 2013. Development of a recombinant N-Gp5c fusion protein-based ELISA for detection of antibodies to porcine reproductive and respiratory syndrome virus. J Virol Methods. 4:189(1):213-20
33. Sh Cao, Yi Shi, Sh-G Tan, H Song, George F. Gao*, W-J Liu*. 2012. Reply to "Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1"--Sequence Sharing Between Viral Nuclear Export Signals (NES) and CD8+ T Cell Epitopes. Journal of Virology, 86(18):10259-10260
34. M-R Yu#, X-L Liu#, Sh Cao, Zh-D Zhao, K Zhang, Q Xie, C-W Chen, Sh-Y Gao, Y-H Bi, L Sun, X Ye, George F. Gao, W-J Liu*. 2012. Identification and Characterization of three novel nuclear export signals in influenza A virus nucleoprotein. Journal of Virology, 86(9):4970-80
35. Sh Cao, X-L Liu, M-R Yu, J Li, X-J Jia, Y-H Bi, L Sun, George F. Gao, W-J Liu*. 2012. A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for the Efficient Virus Replication. Journal of Virology, 86(9):4883-91
36. X-L Liu#, Zh-D Zhao#, Zh Li, Ch-F Xu, L Sun, J-L Chen, W-J Liu* 2012. Cyclosporin A inhibits the Influenza Virus Replication through cyclophilin A-dependent and -independent pathways. PLoS ONE, 7(5):e37277
37. K Zhang, Zh Wang, X-L Liu, Ch-ch Yin, Basit Zeshan, B Xia*, W-J Liu*. 2012. Dissection of Influenza A Virus M1 Protein: pH-Dependent Oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain. PLoS ONE, 7(5): e37786.
38. X-L Liu#, Zh-D Zhao#, Ch-F Xu, L Sun, J-L Chen, L-F Zhang, W-J Liu*. 2012. Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein. PLoS ONE, 7(2): e31063.
39. C-W Chen, J Li, Y-H Bi, X-J Jia, S-D Meng, L Sun, W-J Liu*. 2012. Gp96 enhances the immunogenicity of subunit 1 vaccine of Porcine reproductive and 2 respiratory syndrome virus. Virus Research, 167(2):162-72.
40. Y-L Wang, J Li, Y-H Bi, L Xu, W-J Liu*. 2012. Development and application of a reverse transcription loop-mediated isothermal amplification method for rapid detection of Duck hepatitis A virus type 1. Virus Genes, doi 10.1007/s11262-012-0798-6
41. Z-F Wang, X-L Liu, Z-D Zhao, C-F Xu, K Zhang, C-W Chen, L Sun, F Gao, X Ye, W-J Liu*, 2011, Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the ribonucleoprotein complex. PLoS ONE 6(8): e22625. doi:10.1371/journal.pone.0022625
42. S-S Meng, L-M Yang, C-F Xu, Z-M Qin, H-Y Xu, Y-L Wang, L Sun and W-J Liu*. Recombinant Chicken Interferon-α Inhibits H9N2 Avian Influenza Virus Replication in vivo by Oral Administration. Journal of Interferon and Cytokine Research. 2011, 7; 31(7):533-8
43. Y-H Bi#, L Lu#, J Li, Y-B Yin, Y Zhang, H-J Gao, Zh-M Qin, Basit Zeshan, J-H Liu, W-J Liu*, L Sun*. Novel genetic reassortants in H9N2 influenza A Viruses and the diverse pathogenicity to mice. Virology Journal, 2011, 8:505
44. L Lu, Y-B Yin, Z-S Sun, L Gao, F Gao, S-D Liu, L Sun* and W-J Liu*. 2010. Genetic correlation between current circulating H1N1 swine and human influenza viruses. Journal of Clinical Virology. 49(3): 186-91.
45. M-R Yu, X-L Liu, L Sun, C-W Chen, G-P Ma, Y. Kitamura, F Gao and W-J Liu*. 2010. Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein. Virus Research. 152(1-2): 104-14.
46. C-F Xu, S-S Meng, X-L Liu, L Sun and W-J Liu*. 2010. Chicken Cyclophilin A is an inhibitory factor to influenza virus replication. Virology Journal. 7(1): 372.
47. Q-H Xue, L-M Yang, X-L Liu and W-J Liu*. 2010. Molecular characterization of feline interferon receptor 2. Journal of Interferon and Cytokine Research. 30(2): 81-8.
48. L Sun, G-H Zhang, Y-L Shu, X-M Chen, Y-P Zhu, L-M Yang, G-P Ma, Y.Kitamura and W-J Liu*. 2009. Genetic correlation between H3N2 human and swine influenza viruses. Journal of Clinical Virology. 44(2): 141-4.
49. X-L Liu, L Sun, M-R Yu, Z-F Wang, C-F Xu, Q-H Xue, K Zhang, X Ye, Y. Kitamura and W-J Liu*. 2009. Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. Cellular Microbiology. 11(5): 730-41.
50. J-J Zhang, G Li, X-L Liu, Z-F Wang, W-J Liu* and X Ye*. 2009. Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA. Journal of General Virology. 90(11): 2751-8.
51. D Liu, X-L Liu, J-H Yan, W-J Liu* and F. Gao*. 2009. Interspecies transmission and host restriction of avian H5N1 influenza virus. Science in China Series C: Life Science. 52(5): 428–38.