Principal Investigator,Professor : Viral Replication and Cell Cycle Regulation

YE Xin
Title:PhD, Professor
Dept.:CAS Key Laboratory of Pathogenic Microbiology and Immunology
Address:1 Beichen West Road, Chaoyang District, Beijing 100101, P. R. China
Dr. Ye graduated from Xiamen University in 1984 and received her Ph.D from the Instiute of Cancer, Chinese Academy of Medical Sciences in 1990. She got her postdoctoral training at Rockefeller University, Columbia University and University of Illinois at Chicago from 1993 to 2000. She worked as an instructor at Baylor College of Medicine and Harvard Medical School from 2000 to 2005. She joined the Institute of Microbiology, CAS as a professor in 2005.
Research Interests
The current research mainly focuses on the study the cell cycle regulation, screening of antiviral drugs and the mechanism of influenza A virus infection.
[1] Yetao Wang, Xiaomei Tong and Xin Ye. 2012. Ndfip1 Negatively Regulates RIG-I–Dependent Immune Signaling by Enhancing E3 Ligase Smurf1-Mediated MAVS Degradation. J Immunol. doi:10.4049.
[2] Yetao Wang#, Xiaomei Tong#, Ehimwenma Sheena Omoregie, Wenjun Liu, Songdong Meng and Xin Ye. 2012. Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner. J Biol. Chem. 287: 34626–34634.
[3] Yetao Wang, Xiaomei Tong, Gang Li, Junhui Li, Min Deng and Xin Ye (2012) Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. Euro. J Immunol. 42: 1304–1315.
[4] Ting Liu, Min Deng, Junhui Li, Xiaomei Tong, Qian Wei and Xin Ye (2011) Phosphorylation of Right Open Reading Frame 2 (Rio2) Protein Kinase by Polo-like Kinase 1 Regulates Mitotic Progression. J Biol. Chem. 286: 36352-36360.
[5] Junhui Li, Min Deng, Qian Wei, Ting Liu, Xiaomei Tong and Xin Ye (2011) Phosphorylation of MCM3 Protein by Cyclin E/Cyclin- dependent Kinase 2 (Cdk2) Protein Regulates Its Function in Cell Cycle. J Biol. Chem. 286:39776-85.
[6] Junjie Zhang , Gang Li and Xin Ye (2010) Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II. J Virol. 84(24):12619-12627.
[7] Min Deng, Fahui Li, Bryan A Ballif, Shan Li, Xi Chen, Lin Guo and Xin Ye (2009)Identification and functional analysis of a novel cyclin E/CDK2 substrate Ankrd17. J Biol. Chem. 284:7875-7888.