Principal Investigator,Professor : Regulation of T Cell Immunity

MENG Songdong
Title:Principal Investigator of Regulation of T-cell Immunity in Viral Infection and Cancer
Dept.:CAS Key Laboratory of Pathogenic Microbiology and Immunology
Address:NO.1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
He got Ph.D degree of Microbiology from Shenyang Institute of Applied Ecology of CAS in 1998. After graduation, he worked as a postdoctoral fellow and then instructor in Cancer Immunobiology Center of UT Southwestern Medical Center at Dallas. He came back to the CAS key lab in 2007 as a scholar of 'Bairen plan' of CAS. Dr. Meng’s current research involves studies of heat shock protein gp96 in innate and acquired immunity, therapeutic vaccine engineering against chronic Hepatitis B Virus (HBV) infection, and cancer targeted therapy.
Research Interests
We currently focus on:
1. Regulation of the immune response against HBV by heat shock protein, and therapeutic vaccine engineering for hepatitis B and cancer therapy
2. Targeted therapeutic approaches against HER2 and uPAR in breast cancer
3. Modulation of HBV replication by MicroRNAs
1. Excellent postdoctoral prize of the Chinese Academy of Sciences, 2001.
2. Second-class prize of 6th Beijing Young thesis in science and technology, 2001.
[1] Junli Hao, Wensong Jin, Xinghui Li, Saifeng Wang, Xiaojun Zhang, Hongxia Fan, Changfei Li, Lizhao Chen, Bin Gao, Guangze Liu, Songdong Meng. 2012. IFN-α-induced miR-122 inhibition negatively affects the anti-HBV efficiency of IFN-α. Journal of Virology, Doi:10.1128/JVI.01710-12.
[2] Saifeng Wang, Lipeng Qiu, Xiaoli Yan, Wensong Jin, Yanzhong Wang, Lizhao Chen, Erjie Wu, Xin Ye, George F Gao, Fusheng Wang, Yu Chen, Zhongping Duan, Songdong Meng. 2012. Loss of MiR-122 Expression in Patients with Hepatitis B Enhances Hepatitis B Virus Replication through Cyclin G1 Modulated P53 Activity. Hepatology, 55:730-741.
[3] Jun Hu, Yaxing Xu, Junli Hao, Saifeng Wang, Changfei Li, Songdong Meng. 2012. MiR-122 in hepatic function and liver diseases.Protein Cell, 3(5):364-71.
[4] Li Y, Song H, Li J, Wang Y, Yan X, Zhao B, Zhang X, Wang S, Chen L, Qiu B, Meng S. 2011. Hansenula polymorpha expressed heat shock protein gp96 exerts potent T cell activation activity as an adjuvant. J Biotechnol. 151(4):343-9.
[5] Saifeng Wang, Lipeng Qiu, Guangze Liu, Yang Li, Xiaojun Zhang, Wensong Jin, George F Gao, Xianping Kong, Songdong Meng. 2011. Heat shock protein gp96 enhances humoral and T cell responses, decreases Treg frequency and potentiates the anti-HBV activity in BALB/c and transgenic mice. Vaccine 29(37):6342-51.
[6] Xiaoli Yan, Xiaojun Zhang, Yanzhong Wang, Xinghui Li, Saifeng Wang, Bao Zhao, Yang Li, Ying Ju, Lizhao Chen, Wenjun Liu, Songdong Meng. 2011. Regulatory T Cell Depletion Synergizes With gp96 Mediated Cellular Responses and Antitumor Activity. Cancer Immunology, Immunotherapy, 60(12):1763-74.
[7] Lipeng Qiu, Hongxia Fan, Wensong Jin, Bao Zhao, Yanzhong Wang, Ying Ju, Lizhao Chen, Yu Chen, Zhongping Duan, Songdong Meng. 2010. miR-122-induced downregulation of HO-1 negatively affects miR-122-mediated suppression of HBV. Biochemical and Biophysical Research Communications 398(4):771-7
[8] Zhen Liu, Xinghui Li, Lipeng Qiu, Xiaojun Zhang, Lizhao Chen, Sheng Cao, Fusheng Wang, Songdong Meng. 2009. Treg suppress CTL responses upon immunization with HSP gp96. European Journal of Immunology, 39:1–11.
[9] Sheng Cao, Yang Li.Jin Li, Changfei Li, Zhang Wei, Zhengqi Yang, Songdong Meng. 2010. Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. Oncology Reports, 23(2):423–8.
[10] Changfei Li, Sheng Cao, Zhen Liu, Xin Ye, Lizhao Chen, Songdong Meng. 2010. RNAi-mediated Downregulation of uPAR Synergizes with Targeting of HER2 Through ERK Pathway in Breast Cancer Cells. International Journal of Cancer 127(7), 1507-16
[11] Songdong Meng, Debu Tripathy, Sanjay Shete, Raheela Ashfaq, Hossein Saboorian, Barbara Haley, Eugene Frenkel, David Euhus, Marilyn Leitch, Cynthia Osborne, Edward Clifford, Steve Perkins, Peter Beitsch, Amanullah Khan, Larry Morrison, Dorothee Herlyn, Leon WMM Terstappen, Nancy Lane, Jianqiang Wang, and Jonathan Uhr. 2006. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proceedings of the National Academy of Sciences of the United States of America, 103(46): 17361-17365.
[12] Songdong Meng, Debasish Tripathy, Eugene P Frenkel, Sanjay Shete, Elizabeth Z Naftalis, James F Huth, Peter D Beitsch, Marilyn Leitch, Susan Hoover, David Euhus, Barbara Haley, Larry Morrison, Timothy P Fleming, Dorothee Herylyn, Leon WMM Terstappen, Tanja Fehm, Thomas F Tucker, Nancy Lane, Jianqiang Wang, Jonathan W Uhr. 2004. Circulating tumor cells in patients with breast cancer dormancy. Clinical Cancer Research, 10(24):8152-8162.
[13] Meng S, Tripathy D, Shete S, Ashfaq R, Haley B, Perkins S, Beitsch P, Khan A, Euhus D, Osborne C, Frenkel E, Hoover S, Leitch M, Clifford E, Vitetta E, Morrison L, Herlyn D, Terstappen LW, Fleming T, Fehm T, Tucker T, Lane N, Wang J, Uhr J. 2004. HER-2 gene amplification can be acquired as breast cancer progresses. Proceedings of the National Academy of Sciences of the United States of America, 101(25):9393-9398.
[14] Meng S, Song J, Rao Z, Tien P, Gao G. 2002. Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides. Journal of Immunological Methods, 264(1-2): 29-35.
[15] Songdong Meng, Tong Gao, George F. Gao, Po Tien. 2001. HBV-specific peptide associated with heat shock protein gp96. Lancet, 357(17): 528-529. Seletcted Patents:
1. Bo Tian, Songdong Meng, George F. Gao, Hepatitis B virus (HBV) antigenic polypeptide-heat shock protein complex and use thereof, ZL 01 1 04060.2,2003.
2. Bo Tian, Songdong Meng, George F. Gao. Complex of hepatitis B virus-specific antigenic peptides associated with heat shock proteins and the application thereof. US 7247 712 B2, Jul.24, 2007.