Principal Investigator,Professor : Chemical Glycobiology and Antivirals Lab

LI Xuebing (Professor, Ph.D)
Title:Principal Investigator
Dept.:CAS Key Laboratory of Pathogenic Microbiology and Immunology
Address:No.8 Zhongguancun Beiertiao Road, Haidian District, Beijing, 100190, P.R.China
Dr. Li received his PhD in molecular engineering from Tottori University (Japan) in 2000. He worked as Postdoctoral Fellow at National Institute of Agrobiological Science (Japan) from 2000 to 2001, and Research Fellow at Hokkaido University (Japan) from 2001 to 2006. He joined the Institute of Microbiology, Chinese Academy of Sciences in 2007. He has over 10 publications in recent years in the related fields involved in Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Biomacromolecules, etc.
Research Interests
Dr. Li’s group is mainly interested in glycochemistry and chemical glycobiology. The research area covers carbohydrate chemistry, organic synthesis, and biochemistry. Current research topics are:
1. Construction of new strategy on oligosaccharide synthesis;
2. Discovery of novel anti-infective agents based on carbohydrate syntheses;
3.Construction of rapid detection methods on infectious pathogens through the combined use of glycotechnology and nanotechnology.
[1] Dingbin Liu, Wenwen Chen Jinhua Wei, Xuebing Li, Zhuo Wang, and Xingyu Jiang*. A Highly Sensitive, Dual-Readout Assay Based on Gold Nanoparticles for Organophosphorus and Carbamate Pesticides. Analytical Chemistry 2012, 84, 4185–4191.
[2] Xuebing Li*, Peixing Wu, Shuihong Cheng, and Xun Lv. Synthesis and Assessment of Globotriose–Chitosan Conjugate, a Novel Inhibitor of Shiga Toxins Produced by Escherichia coli. Journal of Medicinal Chemistry 2012, 55, 2702?2710.
[3] Xuebing Li*, Peixing Wu, George F. Gao, and Shuihong Cheng. Carbohydrate-Functionalized Chitosan Fiber for Influenza Virus Capture. Biomacromolecules 2011, 12, 3962–3969.
[4] Yongmeng Li, Yan Zhou, Yufang Ma, and Xuebing Li*. Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU. Carbohydrate Research 2011, 346, 1714–1720.
[5] Jing Han and Xuebing Li*. Chemoenzymatic Syntheses of Sialyl Lewis X-chitosan Conjugate as Potential Anti-inflammatory Agent. Carbohydrate Polymers 2011, 83, 137–143.
[6] Qing Li, Jianxun Qi, Wei Zhang, Christopher J. Vavricka, Yi Shi, Jinhua Wei, Enguang Feng, Jingshan Shen, Jilong Chen, Di Liu, Jianhua He, Jinghua Yan, Hong Liu, Hualiang Jiang, Maikun Teng, Xuebing Li, and George F. Gao*. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nature Structural and Molecular Biology 2010, 17, 1266–1268.
[7] Yaozu Xu, Hongjie Fan, Chengping Lu, George F. Gao, and Xuebing Li*. Synthesis of Galabiose-chitosan Conjugate as Potent Inhibitor of Streptococcus suis Adhesion. Biomacromolecules 2010, 11, 1701–1704.
[8] Xue-Bing Li, Masato Ogawa, Toshiki Monden, Takahiro Maeda, Eri Yamashita, Mariko Naka, Masao Matsuda, Hiroshi Hinou, Shin-Ichiro Nishimura, 2006, Glycosidation Promoted by a Reusable Solid Superacid in Supercritical Carbon Dioxide, Angew. Chem. Int. Ed., 45, 5652-5655.