Principal Investigator,Professor : Infectious diseases and Immunosenescence research group

Title:PhD, Professor
Dept.:CAS Key Laboratory of Pathogenic Microbiology and Immunology
Address:1 Beichen West Road, Chaoyang District, Beijing 100101, P. R. China
Dr. Fang graduated from Lanzhou University in 1994 and received her Ph.D from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2003. She got her postdoctoral training at Fox Chase Cancer Center from 2003 to 2008. She worked as a research associate and then as a staff scientist at Fox Chase Cancer Center from 2008 to 2012. She joined the Institute of Microbiology, CAS in 2012.
Research Interests
The current research in our laboratory mainly focuses on understanding the role of Natural Killer (NK) cells in infectious diseases and cancers, especially the role of age-dependent defect of NK cells in regulating increased susceptibility to viral infections and cancer carcinogenesis.
Selected Publications and Books (# Corresponding Author):
1. Peng S, Wang J, Wei S, Li C, Zhou K, Hu J, Ye X, Yan J, Liu W, Gao GF, Fang M#, Meng S#. Endogenous Cellular microRNAs Mediate Antiviral Defense against Influenza A Virus. Molecular Therapy Nucleic Acids. 2017, DOI: 10.1016/j.omtn.2017.12.016 [Epub ahead of print]
2. Lu J, Duan X, Zhao W, Wang J, Wang H, Zhou K, Fang M#. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology. Aging and Disease. 2017, [Epub ahead of print]
3. Duan X, Li S, Wong G, Wang D, Wang H, Lu J, Bi Y, Lu X, Shi Y, Yan J, Fang M#, Gao GF#. Natural killer cells are activated and play a protective role against ZIKA virus infection in mice. Sci Bullet, 2017, 62:982-984.

4. Duan X, Lu J, Wang H, Liu X, Wang J, Zhou K, Jiang W, Wang Y, Fang M#. Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection. Exp Gerontol. 2017, 96:127-137.
5. Wang J, Yang G, Wang D, Liu K, Ma Y, Liu H, Wu J#, Fang M#. Changes of peripheral lymphocyte subsets and cytokine environment during ageing and deteriorating gastrointestinal tract health status. Oncotarget. 2017, 8(37):60764-60777.
6. Jiang W, Sheng C, Gu X, Liu D, Yao C, Gao S, Chen S, Huang Y, Huang W#, Fang M#. Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication. Sci Rep. 2016, 6:35041. doi: 10.1038/srep35041.
7. Zhou K, Wang J, Fang M#. NK Cell Responses to Influenza Virus are Affected by Host Genetics and Infecting Viral Doses. Austin Immunology. 2016, 1(1):1-2.
8. Zhou K, Wang J, Li A, Zhao W, Wang D, Zhang W, Yan J, Gao GF, Liu W, Fang M#. Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection. J Immunol. 2016, 196(4):1842-54.
9. Fang M#, Sigal LJ#. Protective CD8+ T cell memory without help. Oncotarget. 2015;6(30):28529-28530.

10. Duan X, Lu J, Zhou K, Wang J, Wu J, Gao GF, Fang M#. Natural Killer Cells are involved in Thymic Atrophy induced by Influenza A Virus Infection. J Gen Virol. 2015, 96:3223–3235
11. Bi J, Wang J, Zhou K, Wang Y, Fang M#, Du Y#. Synthesis and Biological Activities of 5-Thio-α-GalCers. ACS Med Chem Lett, 2015, 6(4): 476–480.
12. Fang M#, Remakus S, Roscoe F, Ma X, Sigal LJ#. CD4+ T Cell Help Is Dispensable for Protective CD8+ T Cell Memory against Mousepox Virus following Vaccinia Virus Immunization. J Virol. 2015; 89(1):776-83.
13. Dongfang Wang, Yongchao Ma, Jing Wang, Xiaoman Liu, Min Fang#. Natural Killer cells in Innate Defense against Infective Pathogens. Journal of Clinical & Cellular Immunology. 2013; 10.4172/2155-9899.S13-006
14. Ma Yongchao, Fang Min#. Immunosenescence and age-related viral diseases, Science China. Life sciences. 2013; 56: 399-405.
15. Fang M, Siciliano N, Hersperger A, Roscoe F, Hu A, Ma X, Shamsedeen A, Eisenlohr L and Sigal L. Perforin-dependent CD4+ T cell cytotoxicity contributes to control a murine poxvirus infection. PNAS. 2012; 109(25):9983-8.
16. Fang M, Orr M, Spee P, Egebjerg T, Lanier L, and Sigal LJ. CD94 is essential for NK cell-mediated resistance to a lethal viral disease. Immunity. 2011, 34(4):579-89.

17. Fang M, Roscoe F, Sigal LJ. Age-dependent susceptibility to a viral disease due to decreased NK cell numbers and trafficking. J Exp Med. 2010;207(11):2369-81.
18. Fang M and Sigal L. Studying NK cell responses to ectromelia virus infections in mice. Methods Mol Biol. 2010;612:411-28.
19. Fang M, Lanier LL, Sigal LJ. A Role for NKG2D in NK Cell-Mediated Resistance to Poxvirus Disease. PLoS Pathogen. 2008, 4(2):e30
20. Xu RH*, Fang M*, Klein-Szanto A, Sigal LJ. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc Natl Acad Sci U S A. 2007, 104(26):10992-7. (* Co-first author)
21. Fang M, Sigal LJ. Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host. J Immunol. 2006, 177(11):8027-36.
22. Fang M, Cheng H, Dai Z, Bu Z, Sigal LJ. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host. Virology. 2006,345(1):231-43.
23. Fang M, Sigal LJ. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol. 2005, 175(10): 6829-36.
24. Fang M, Zhao R, Yang Z, Zhang Z, Li H, Zhang XT, Lin Q, Huang HL. Characterization of an anti-human ovarian carcinoma×anti-human CD3 bispecific single-chain antibody with an albumin-original interlinker. Gynecol Oncol. 2004, 92:135-146.