WANG Shuo----微生物研究所

CAS Key laboratory of Pathogenic Microbiology & Immunology

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Principal Investigator,Professor :

WANG Shuo

Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China

Telephone/fax：010-64806162

E-mail：wangshuo@im.ac.cn

Research Interests

1) Construction and regulation of immune cells during infection in mucosal immune system;
2) Interaction of intestinal microbiota and immune cells under homeostatic and pathological circumstance.

Education/degrees

(1)（1）Dr. Wang graduated from Zhejiang University in 2006
(2)（2）Dr. Wang got PhD degree from University of CAS in 2012.

Work experience

(1)（1）2015-2019, Dr. Wang served as an Investigator in Institute of Biophysics, CAS.
(2)（1）Since 2019 till now, Dr. Wang serves as a Principal Investigator in Institute of Microbiology, CAS.

The main research areas

1)1）Establishment and regulation of immune cells in the mucosal immune system. In this program, we have performed single cell sequencing of ILCs in mucosal immune system, and analyzed phenotypes and feature markers of ILCs. We further analyzed the trajectory of ILC maturation in the mucosal immune system.
2)1）Regulation of ILCs in the intestinal immune system during infection. We found that several transcription factors and chemokines could regulate ILCs in defending intestinal bacteria infection.

Publication

1、Wang S*#, Xia P#, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z*. Regulatory innate lymphoid cells control innate intestinal inflammation. Cell. 2017.171. 201–216.

2、Wang S*#, Qu Y#, Xia P#, Chen Y#, Zhu X, Zhang J, Wang G, Tian Y#, Ying J*, Fan Z*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer, Cell Research, 2020. 30. 610–622.

3、Xia P#, Wang S*#, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z*. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018. 48. 688-701 e687.

4、Xia P#, Wang S#, Xiong Z#, Zhu X#, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y, Fan Z. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat. Immunol. 2018. 19.141-150.

5、Wang S#, Xia P#, Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nat Commun.2016.7.11023.

6、Wang S#, Xia P#, Chen Y, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan, Z. Natural killer-like B cells prime innate lymphocytes against microbial infection. Immunity. 2016.45. 131-144.

7、Xia P#, Ye B#, Wang S#, Zhu X#, Du Y, Xiong Z, Tian Y, Fan Z. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016. 17. 369-378.

8、Shao F, Yu D, Xia P, Wang S*. Dynamic regulation of innate lymphoid cells in the mucosal immune system. Cell Mol Immunol. 2021. 18. 1387-1394.

9、Ma J, Zhu F, Zhao M, Shao F, Yu D, Ma J, Zhang X, Li W, Qian Y, ZhangY, Jiang D,Wang S*, Xia P*. SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. EMBO J. 2021. 40. e108249.