Principal Investigators
State Key Laboratory of Microbial Resources
State Key Laboratory of Mycology
CAS Key laboratory of Microbial Physiological and Metabolic Engineering
State Key Laboratory of Plant Genomics(Co-established with Institute of Genetics and Developmental Biology, CAS)
CAS Key laboratory of Pathogenic Microbiology & Immunology
The Center for Microbial Resource and Big Data-
CAS Key laboratory of Pathogenic Microbiology & Immunology
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Principal Investigator,Professor :

DENG Tao
Address：NO.1 West Beichen Road, Chaoyang District, Beijing 100101, China
Telephone/fax：010-64807980
E-mail：dengt@im.ac.cn
Research Interests
Molecular mechanisms of influenza virus RNA syntheses and gene expressions The role of the viral RNA structures in regulation of the virus replication. The role of host factors in viral replication and host-range determinations Research and Development of influenza vaccines and antivirals.
Education/degrees
1988.09-1992.06 BSc in Biological Sciences, Department of Biology, Lanzhou University, P.R. China 2002.11-2006.03 DPhil in Molecular Virology, Sir William Dunn School of Pathology, Oxford University, UK
Work experience
06/1992-08/2000 Research Assistant, Lanzhou Institute of Biological Products (LIBP), Ministry of Public Health, Lanzhou, China 04/2001-11/2001 Academic Visitor, Sir William Dunn School of Pathology, University of Oxford, UK 11/2001-03/2006 Research Assistant, Sir William Dunn School of pathology, University of Oxford. UK 04/2006-12/2008 Postdoctoral Research Scientist, Sir William Dunn School of Pathology, University of Oxford, UK 01/2009-10/2009 Senior Scientist, National Institute of Biological Standard And Control (NIBSC), London, UK 10/2009-03/2020 Primary Investigator, Institute of Pathogen Biology, Chinese Academy of Medical Science 03/2020- present Primary Investigator, Institute of Microbiology, Chinese Academy of Sciences
The main research areas
Research on influenza viruses at the molecular level R&D on influenza vaccines and antivirals
Publication

1.Xiao Y, Zhang W, Pan M, Bauer DLV, Bi Y, Cao M, Fodor E, Deng T. A synergistic effect between 3' terminal noncoding and adjacent coding regions of influenza A virus HA segment on template preference. J. Virol. 2021 Jun doi: 10.1128/JVI.00878-21.

2.Gao S, Zhang W, Lu C, Cao M, Cen S, Peng Y, Deng T. Identification of a Type-Specific Promoter Element That Differentiates between Influenza A and B Viruses. J. Virol. 2019 Nov 13;93(23):e01164-19. doi: 10.1128/JVI.01164-19

3.Wang J, Li J, Zhao L, Cao M, Deng T.  Dual Roles of the Hemagglutinin Segment-Specific Noncoding Nucleotides in the Extended Duplex Region of the Influenza A Virus RNA Promoter. J Virol. 2017, 91(1), e01931-16.

4.Wang J, Peng Y, Zhao L, Cao M, Hung T, Deng T. Influenza A virus Utilizes a Suboptimal Kozak Sequence to Fine-tune Virus Replication and Host Response. J Gen Virol. 2014 Dec 17. doi: 10.1099/vir.0.00003

5.Li C, Wu A, Peng Y, Wang J, Guo Y, Chen Z, Zhang H, Wang Y, Dong J, Wang L, Qin FX, Cheng G, Deng T*, Jiang T*. Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein. Sci Rep. 2014, 26;4:7192. doi: 10.1038/srep07192. (*co-corresponding authors).

6.Cao M, Wei C, Zhao L, Wang J, Jia Q, Wang X, Jin Q, Deng T. DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity. J Virol. 2014, 88(24): 14078-14089.

7.Zhao L, Peng Y, Zhou K, Cao M, Wang J, Wang X, Jiang T, Deng T. New Insights into the Nonconserved Noncoding Region of the Subtype-Determinant Hemagglutinin and Neuraminidase Segments of In？uenza A Viruses. J Virol. 2014, 88(19): 11493-11503.

8.Zhou Z, Cao M, Guo Y, Zhao L, Wang J, Jia X, Li J, Wang C, Gabriel G, Xue Q, Yi Y, Cui S, Jin Q*, Wang J*, Deng T*. Fragile X mental retardation protein stimulates ribonucleoprotein assembly of Influenza A virus. Nat Commun. 2014,5:3259.

9.Li C, Ba Q, Wu A, Zhang H, Deng T*, Jiang T*. A peptide derived from C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly. FEBS J. 2012 280(4):1139-49.  (*co-corresponding authors).

10.Dreger M, Leung BW, Brownlee GG*, Deng T*. A quantitative proteomics strategy to detect protein regions affected by protein-protein interactions. Protein Science 2009, 18(7):1448-58..

11.Chase G*, Deng T*, Fodor E, Mayer D, Schwemmle M and Brownlee GG (2008), Hsp90 inhibitors reduce influenza virus replication in cell culture. Virology 2006 377(2):431-439 (* co-first authors).

12.Fodor E, Engelhardt OG, Smith M, Sharps J, Brownlee GG, Deng T* (2007). Nuclear import and assembly of the influenza virus RNA polymerase complex. In “Options for the Control of Influenza VI” 2007, Elsevier Science, Toronto, Canada.

13.Deng T*, Engelhardt OG*, Thomas B, Akoulitchev AV, Brownlee GG and Fodor E. The role of Ran binding protein 5 (RabBP5) in the nuclear import and assembly of he influenza virus RNA polymerase complex. J Virol. 2006 80:11911-11919.

14.Deng T, Sharps J, Brownlee GG. The role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication. J Gen.Virol. 2006, 87: 3373-3377.   

15.Deng T*, Vreede FT*, Brownlee GG. Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication. J Virol. 2006, 80:2337-2348..

16.Deng T, Sharps J, Fodor E, Brownlee GG. In vitro assembly of PB2 with PB1-PA dimer supports a new model assembly of influenza A virus polymerase subunits into a functional trimeric complex. J Virol. 2005, 79:8669-8674

17.Crow M*, Deng T*, Addley M, Brownlee GG. Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication. J Virol. 2004, 78:6263-6270. (* co-first authors)